ChemicalBook > CAS DataBase List > LRRK2-kinase inhibitor
LRRK2-kinase inhibitor
- Product Name
- LRRK2-kinase inhibitor
- CAS No.
- 1285515-21-0
- Chemical Name
- LRRK2-kinase inhibitor
- Synonyms
- CS-1790;GSK2578215;SK2578215A;GSK2578125A;GSK2578215A;GSK2578215A, >=98%;LRRK2-kinase inhibitor;GSK2578215A >=98% (HPLC);LRRK2 inhibitor GS2578215A;GSK2578215A, 10 mM in DMSO
- CBNumber
- CB92628049
- Molecular Formula
- C24H18FN3O2
- Formula Weight
- 399.42
- MOL File
- 1285515-21-0.mol
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LRRK2-kinase inhibitor Property
- Boiling point:
- 556.1±50.0 °C(Predicted)
- Density
- 1.292±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble15mg/mL, clear
- form
- powder
- pka
- 12.31±0.70(Predicted)
- color
- white to beige
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Safety
- WGK Germany
- 3
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML0660
- Product name
- GSK2578215A
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $119
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- SML0660
- Product name
- GSK2578215A
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $482
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 14603
- Product name
- GSK2578215A
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $57
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 14603
- Product name
- GSK2578215A
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $107
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 14603
- Product name
- GSK2578215A
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $249
- Updated
- 2024/03/01
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LRRK2-kinase inhibitor Chemical Properties,Usage,Production
Uses
GSK2578215A is a potent, selective LRRK2 inhibitor and a promising therapeutic for treating Parkinson''s disease.
Biological Activity
GSK2578215A is a potent inhibitor of leucine-rich repe at kinase-2 (LRRK2) also known as dardarin or PARK8, a kinase with mutations linked to Parkinson′s disease. Because the most common mutation, G2019S, enhances LRRK2 kinase activity, it is hoped th at LRRK2 inhibitors may be useful in treating the disease. GSK2578215A inhibited both wild-type and G2019S mutant LRRK2 kinase activity with IC50s of 10.9 and 8.9 nM respectively. It has good blood-brain barrier (BBB) permeability with a high ratio of brain to plasma distribution in mice.', 'GSK2578215A stimulates mitochondrial fragmentation, autophagy and mitophagy.
storage
Store at RT
LRRK2-kinase inhibitor Preparation Products And Raw materials
Raw materials
Preparation Products
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LRRK2-kinase inhibitor Suppliers
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View Lastest Price from LRRK2-kinase inhibitor manufacturers
Career Henan Chemical Co
- Product
- LRRK2-kinase inhibitor 1285515-21-0
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2019-12-23