OSI-754

Product Name: OSI-754
CAS No.: 1190094-64-4
Chemical Name: OSI-754
Synonyms: OSI-754;LNK 754;CP 609754;CP-609754(OS1754);CP-609754 (OSI754);CP-609754, 10 mM in DMSO;CP-609754 (OSI754, LNK 754);6-[(R)-(4-chlorophenyl)-hydroxy-(3-methylimidazol-4-yl)methyl]-4-(3-ethynylphenyl)-1-methylquinolin-2-one;2(1H)-Quinolinone, 6-[(R)-(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-ethynylphenyl)-1-methyl-;(R)-6-((4-Chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-ethynylphenyl)-1-methylquinolin-2(1H)-one
CBNumber: CB92628221
Molecular Formula: C29H22ClN3O2
Formula Weight: 479.96
MOL File: 1190094-64-4.mol

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OSI-754 Property

Boiling point:: 702.4±60.0 °C(Predicted)
Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 100 mg/mL (208.35 mM; Need ultrasonic)
form: Solid
pka: 12.28±0.29(Predicted)
color: Off-white to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

DC Chemicals

Product number: 020560
Product name: CP-609754(OSI754)
Packaging: 001
Price: $950
Updated: 2021/12/16

DC Chemicals

Product number: 020560
Product name: CP-609754(OSI754)
Packaging: 002
Price: $1900
Updated: 2021/12/16

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OSI-754 Chemical Properties,Usage,Production

Uses

CP-609754 (LNK-754) is a potent and reversible farnesyltransferase inhibitor with potential anticancer activity.The IC50 for inhibiting farnesylation of recombinant human H-Ras is 0.57 ng/mL and recombinant K-Ras is 46 ng/mL[1]. CP-609754 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

in vivo

CP-609754 (CP-609,754) has antitumor activity against 3T3 H-ras (61L) tumors in vivo^[1].
? With twice daily oral dosing of CP-609754, tumor regression is achieved with a dose of 100 mg/kg; the ED₅₀ for tumor growth inhibition is 28 mg/kg^[1].?
? With continuous i.p. infusion of CP-609754, tumor growth is inhibited by >50%, and tumor farnesyltransferase activity inhibited by >30% in mice in which the plasma concentration of CP-609754 is maintained above 118 ng/mL^[1].

References

[1] Stacy L Moulder, et al. A phase I open label study of the farnesyltransferase inhibitor CP-609,754 in patients with advanced malignant tumors. Clin Cancer Res. 2004 Nov 1;10(21):7127-35. DOI:10.1158/1078-0432.CCR-04-0901

OSI-754 Preparation Products And Raw materials

Raw materials

Preparation Products

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OSI-754 Suppliers

China 36 United States 5 Global 41

Chengdu Celes Technology Co., Ltd

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Shanghai Boyle Chemical Co., Ltd.

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View Lastest Price from OSI-754 manufacturers

Chengdu Henghui Pharm Tec Co. Ltd.

Product: CP-609754 1190094-64-4
Price: US $1.00-1.00/G
Min. Order: 1MG
Purity: >98%
Supply Ability: 100G
Release date: 2018-07-21

1190094-64-4, OSI-754Related Search:

OSI-754

CP 609754

LNK 754

CP-609754 (OSI754)

6-[(R)-(4-chlorophenyl)-hydroxy-(3-methylimidazol-4-yl)methyl]-4-(3-ethynylphenyl)-1-methylquinolin-2-one

2(1H)-Quinolinone, 6-[(R)-(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-ethynylphenyl)-1-methyl-

CP-609754(OS1754)

CP-609754 (OSI754, LNK 754)

Malignant,farnesylation,Farnesyltransferase,Tumor,Inhibitor,LNK-754,CP-609754,H-Ras,Ftase,OSI 754,Farnesyl Transferase,LNK 754,OSI-754,inhibit,OSI754,CP 609754,LNK754,K-Ras,Advanced,CP609754

CP-609754, 10 mM in DMSO

(R)-6-((4-Chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-ethynylphenyl)-1-methylquinolin-2(1H)-one

1190094-64-4

C29H22ClN3O2