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OSI-754

Product Name
OSI-754
CAS No.
1190094-64-4
Chemical Name
OSI-754
Synonyms
OSI-754;LNK 754;CP 609754;CP-609754(OS1754);CP-609754 (OSI754);CP-609754, 10 mM in DMSO;CP-609754 (OSI754, LNK 754);6-[(R)-(4-chlorophenyl)-hydroxy-(3-methylimidazol-4-yl)methyl]-4-(3-ethynylphenyl)-1-methylquinolin-2-one;2(1H)-Quinolinone, 6-[(R)-(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-ethynylphenyl)-1-methyl-;(R)-6-((4-Chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-ethynylphenyl)-1-methylquinolin-2(1H)-one
CBNumber
CB92628221
Molecular Formula
C29H22ClN3O2
Formula Weight
479.96
MOL File
1190094-64-4.mol
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OSI-754 Property

Boiling point:
702.4±60.0 °C(Predicted)
Density 
1.23±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 100 mg/mL (208.35 mM; Need ultrasonic)
pka
12.28±0.29(Predicted)
form 
Solid
color 
Off-white to yellow
InChI
InChI=1/C29H22ClN3O2/c1-4-19-6-5-7-20(14-19)24-16-28(34)33(3)26-13-10-22(15-25(24)26)29(35,27-17-31-18-32(27)2)21-8-11-23(30)12-9-21/h1,5-18,35H,2-3H3/t29-/s3
InChIKey
JAHDAIPFBPPQHQ-NNFJEGBSNA-N
SMILES
N1(C)C2=C(C=C([C@@](C3=CC=C(Cl)C=C3)(O)C3N(C)C=NC=3)C=C2)C(C2=CC=CC(C#C)=C2)=CC1=O |&1:6,r|
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

DC Chemicals
Product number
020560
Product name
CP-609754(OSI754)
Packaging
001
Price
$950
Updated
2021/12/16
DC Chemicals
Product number
020560
Product name
CP-609754(OSI754)
Packaging
002
Price
$1900
Updated
2021/12/16
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OSI-754 Chemical Properties,Usage,Production

Uses

CP-609754 (LNK-754) is a potent and reversible farnesyltransferase inhibitor with potential anticancer activity.The IC50 for inhibiting farnesylation of recombinant human H-Ras is 0.57 ng/mL and recombinant K-Ras is 46 ng/mL[1]. CP-609754 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

in vivo

CP-609754 (CP-609,754) has antitumor activity against 3T3 H-ras (61L) tumors in vivo[1].
With twice daily oral dosing of CP-609754, tumor regression is achieved with a dose of 100 mg/kg; the ED50 for tumor growth inhibition is 28 mg/kg[1].
With continuous i.p. infusion of CP-609754, tumor growth is inhibited by >50%, and tumor farnesyltransferase activity inhibited by >30% in mice in which the plasma concentration of CP-609754 is maintained above 118 ng/mL[1].

References

[1] Stacy L Moulder, et al. A phase I open label study of the farnesyltransferase inhibitor CP-609,754 in patients with advanced malignant tumors. Clin Cancer Res. 2004 Nov 1;10(21):7127-35. DOI:10.1158/1078-0432.CCR-04-0901

OSI-754 Preparation Products And Raw materials

Raw materials

Preparation Products

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OSI-754 Suppliers

China 38 United States 5 Global 43
Chengdu Celes Technology Co., Ltd
Tel
19982073091
Email
2538834896@qq.com
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China
ProdList
78
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58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
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55
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4827
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55
Shanghaizehan biopharma technology co., Ltd.
Tel
021-61350663 13052117465
Fax
021-61350662
Email
sales@zehanbiopharma.com
Country
China
ProdList
977
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55
SPIRO PHARMA
Tel
Fax
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Email
eric_feng1954@126.com
Country
China
ProdList
9248
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55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
88915
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60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
7999
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Shanghai Rechem science Co., Ltd.
Tel
021-31433387 15618786686
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QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2962
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Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9550
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58
Chuzhou KeMail Chemical Technology Co., Ltd
Tel
0550-5196001 15000891977
Fax
0550-5196001
Email
wj520wjxby@126.com
Country
China
ProdList
1946
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View Lastest Price from OSI-754 manufacturers

Chengdu Henghui Pharm Tec Co. Ltd.
Product
CP-609754 1190094-64-4
Price
US $1.00-1.00/G
Min. Order
1MG
Purity
>98%
Supply Ability
100G
Release date
2018-07-21

1190094-64-4, OSI-754Related Search:


  • OSI-754
  • CP 609754
  • LNK 754
  • CP-609754 (OSI754)
  • 6-[(R)-(4-chlorophenyl)-hydroxy-(3-methylimidazol-4-yl)methyl]-4-(3-ethynylphenyl)-1-methylquinolin-2-one
  • 2(1H)-Quinolinone, 6-[(R)-(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-ethynylphenyl)-1-methyl-
  • CP-609754(OS1754)
  • CP-609754 (OSI754, LNK 754)
  • Malignant,farnesylation,Farnesyltransferase,Tumor,Inhibitor,LNK-754,CP-609754,H-Ras,Ftase,OSI 754,Farnesyl Transferase,LNK 754,OSI-754,inhibit,OSI754,CP 609754,LNK754,K-Ras,Advanced,CP609754
  • CP-609754, 10 mM in DMSO
  • (R)-6-((4-Chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-ethynylphenyl)-1-methylquinolin-2(1H)-one
  • 1190094-64-4
  • C29H22ClN3O2