ChemicalBook > CAS DataBase List > SQ 109
SQ 109
- Product Name
- SQ 109
- CAS No.
- 502487-67-4
- Chemical Name
- SQ 109
- Synonyms
- SQ 109;NSC 722041;Cenobamate;SQ109 (NSC 722041);SQ109 >=98% (HPLC);SQ109, 10 mM in DMSO;SQ 109; SQ-109; NSC 722041;N'-(2-adamantyl)-N-[(2E)-3,7-dimethylocta-2,6-dienyl]ethane-1,2-diamine;1,2-Ethanediamine,N-[(2E)-3,7-dimethyl-2,6-octadienyl]-N'-tricyclo[3.3.1.13,7]dec-2-yl-;1,2-Ethanediamine,N-[(2E)-3,7-dimethyl-2,6-octadienyl]-N'-tricyclo[3.3.1.13,7]dec-2-yl-
- CBNumber
- CB92628423
- Molecular Formula
- C22H38N2
- Formula Weight
- 330.55
- MOL File
- 502487-67-4.mol
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SQ 109 Property
- Boiling point:
- 450.0±33.0 °C(Predicted)
- Density
- 0.97±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly)
- form
- oil
- pka
- 9.80±0.20(Predicted)
- color
- colorless to yellow
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML1309
- Product name
- SQ109
- Purity
- ≥98% (HPLC)
- Packaging
- 10MG
- Price
- $326
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- SML1309
- Product name
- SQ109
- Purity
- ≥98% (HPLC)
- Packaging
- 50MG
- Price
- $924
- Updated
- 2025/07/31
ChemScene
- Product number
- CS-1188
- Product name
- SQ109
- Purity
- 98.01%
- Packaging
- 50mg
- Price
- $1195
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-1188
- Product name
- SQ109
- Purity
- 98.01%
- Packaging
- 100mg
- Price
- $1440
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- A3834
- Product name
- SQ109
- Packaging
- 50mg
- Price
- $1460
- Updated
- 2021/12/16
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SQ 109 Chemical Properties,Usage,Production
Uses
SQ109 has been used:
- as an antitubercular?agent to study its interactions with mycobacterial membrane proteins large 3 (MmpL3) binding pocket
- as a positive control to determine the minimum inhibitory concentration (MIC) of ohmyungsamycins (OMS) A and B against Mycobacterium tuberculosis?(Mtb) using the resazurin microtiter assay (REMA) plate method
- as an inhibitor of MmpL3 to explore the utility of mycobacterial CRISPR interference for validating target gene essentiality and compound mode of action
General Description
SQ109 is a 1,2-ethylenediamine, which is related to ethambutol.
Biochem/physiol Actions
SQ109 exhibits activity against Helicobacter pylori and the fungi Candida albicans. It might also possess anti-bacterial activity.
in vivo
Oral administration of SQ109 (0.1-25 mg/kg per day) to the mice for 28 days results in dose-dependent reductions of mycobacterial load in both spleen and lung comparable to that of EMB administered at 100 mg/kg per day, but is less potent than isoniazid (INH) at 25 mg/kg per day. Pharmacokinetic profiles of SQ109 in mice following a single administration showed its Cmax as 1038 (intravenous (i.v.)) and 135 ng/mL (p.o.), with an oral Tmax of 0.31 h. The elimination t1/2 of SQ109 is 3.5 (i.v.) and 5.2 h (p.o.). The oral bioavailability is 4%[2]. The terminal half-life (t1/2) of SQ109 in dogs (12-29 h, mean 29.3 h) is longer than in rats (7-8 h, mean 7.4 h), as reflected by the significantly larger volume of distribution of SQ109 in dogs. The oral bioavailability of SQ109 in rats and dogs is determined to be 12% and 5%, respectively[3].
target
Mycobacterium
IC 50
Trypanosoma
SQ 109 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from SQ 109 manufacturers
Guangzhou Tosun Pharmaceutical Ltd
- Product
- Cenobamate 502487-67-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 5kg
- Purity
- 98%-102%
- Supply Ability
- 200kg
- Release date
- 2024-12-27
ShenZhen H&D Pharmaceutical Technology Co., LTD
- Product
- Cenobamate
- Price
- US $0.00/mg
- Min. Order
- 10mg
- Purity
- 0.98
- Supply Ability
- 5g
- Release date
- 2025-03-21
Chengdu Aupone Pharmaceutical Co.Ltd.
- Product
- Cenobamate
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99.99
- Supply Ability
- 10Tons
- Release date
- 2025-01-08