4-BroMo-5-fluoro-2-nitro-benzoic acid Methyl ester
- Product Name
- 4-BroMo-5-fluoro-2-nitro-benzoic acid Methyl ester
- CAS No.
- 1220886-29-2
- Chemical Name
- 4-BroMo-5-fluoro-2-nitro-benzoic acid Methyl ester
- Synonyms
- Methyl 4-broMo-5-fluoro-2-nitrobenzoate;2-nitro-4-bromo-5-fluorobenzoic acid methyl ester;4-BroMo-5-fluoro-2-nitro-benzoic acid Methyl ester;3-Bromo-2-fluoro-6-nitro-benzoic acid methyl ester;Benzoic acid, 4-bromo-5-fluoro-2-nitro-, methyl ester
- CBNumber
- CB92629677
- Molecular Formula
- C8H5BrFNO4
- Formula Weight
- 278.03
- MOL File
- 1220886-29-2.mol
4-BroMo-5-fluoro-2-nitro-benzoic acid Methyl ester Property
- Boiling point:
- 337.6±42.0 °C(Predicted)
- Density
- 1.742±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to yellow Solid
- InChI
- InChI=1S/C8H5BrFNO4/c1-15-8(12)4-2-6(10)5(9)3-7(4)11(13)14/h2-3H,1H3
- InChIKey
- HPMNCYDJGIMYKN-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)C1=CC(F)=C(Br)C=C1[N+]([O-])=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 4783DT
- Product name
- Methyl4-bromo-5-fluoro-2-nitrobenzoate
- Packaging
- 1g
- Price
- $104
- Updated
- 2021/12/16
- Product number
- 4783DT
- Product name
- Methyl4-bromo-5-fluoro-2-nitrobenzoate
- Packaging
- 5g
- Price
- $188
- Updated
- 2021/12/16
- Product number
- CD12171242
- Product name
- Methyl4-bromo-5-fluoro-2-nitrobenzoate
- Purity
- 98%
- Packaging
- 25g
- Price
- $303
- Updated
- 2021/12/16
- Product number
- A144083
- Product name
- Methyl4-bromo-5-fluoro-2-nitrobenzoate
- Purity
- 98%
- Packaging
- 10g
- Price
- $306
- Updated
- 2021/12/16
- Product number
- CM159081
- Product name
- methyl4-bromo-5-fluoro-2-nitrobenzoate
- Purity
- 95+%
- Packaging
- 25g
- Price
- $327
- Updated
- 2021/12/16
4-BroMo-5-fluoro-2-nitro-benzoic acid Methyl ester Chemical Properties,Usage,Production
Synthesis
1020717-99-0
74-88-4
1220886-29-2
Potassium carbonate (5.870 g, 42.47 mmol) was slowly added to a stirred solution of 4-bromo-5-fluoro-2-nitrobenzoic acid (Ark Pharm, 5.387 g, 20.40 mmol) in N,N-dimethylformamide (DMF, 80.0 mL) at 0 °C, followed by dropwise addition of iodomethane (8.789 g, 61.92 mmol). The reaction mixture was stirred at 0 °C for 15 min and then gradually warmed up to 40 °C and maintained for 2 hours. After completion of the reaction, the mixture was filtered and concentrated. The concentrated residue was dissolved in ethyl acetate (EtOAc, 150 mL), washed sequentially with water (2 x 100 mL) and saturated brine (100 mL), and the organic phase was dried with anhydrous sodium sulfate (Na2SO4), and concentrated under reduced pressure to remove the solvent. The crude product obtained was purified by fast column chromatography on silica gel with the eluent being hexane solution of 0-50% ethyl acetate to give methyl 4-bromo-5-fluoro-2-nitrobenzoate as a light yellow oil (5.348 g, 94% yield). Liquid chromatography-mass spectrometry (LCMS) analysis: theoretically calculated value for C8H6BrFNO4 ([M+H]+): m/z = 277.9; no ionization was observed.
References
[1] Patent: US2014/200216, 2014, A1. Location in patent: Paragraph 0485; 0486
4-BroMo-5-fluoro-2-nitro-benzoic acid Methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-BroMo-5-fluoro-2-nitro-benzoic acid Methyl ester manufacturers
- Product
- 4-BroMo-5-fluoro-2-nitro-benzoic acid Methyl ester 1220886-29-2
- Price
- US $1.00/KG
- Min. Order
- 1g
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-10