ChemicalBook > CAS DataBase List > 5-BroMo-4-fluoropyridin-2-aMine

5-BroMo-4-fluoropyridin-2-aMine

Product Name
5-BroMo-4-fluoropyridin-2-aMine
CAS No.
944401-69-8
Chemical Name
5-BroMo-4-fluoropyridin-2-aMine
Synonyms
152966;5-BroMo-4-fluoropyridin-2-aMine;5-Bromo-4-fluoro-2-pyridinamine;5-bromo-4-fluoropyridine-2-amine;5-bromo-2-amino-4-fluoropyridine;2-aMino-5-broMo-4-fluoropyridine;2-Amino-4-fluoro-5-bromopyridine;2-Pyridinamine, 5-bromo-4-fluoro-;5-Bromo-4-fluoro-pyridin-2-ylamine
CBNumber
CB92629925
Molecular Formula
C5H4BrFN2
Formula Weight
191
MOL File
944401-69-8.mol
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5-BroMo-4-fluoropyridin-2-aMine Property

Boiling point:
233.6±35.0 °C(Predicted)
Density 
1.813±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
4.31±0.24(Predicted)
Appearance
White to off-white Solid
InChI
InChI=1S/C5H4BrFN2/c6-3-2-9-5(8)1-4(3)7/h1-2H,(H2,8,9)
InChIKey
GGHBRLQYBZMEPV-UHFFFAOYSA-N
SMILES
C1(N)=NC=C(Br)C(F)=C1
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

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N-Bromosuccinimide Price

TRC
Product number
B804203
Product name
5-bromo-4-fluoropyridin-2-amine
Packaging
50mg
Price
$45
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB105195
Product name
5-Bromo-4-fluoropyridin-2-amine
Packaging
100mg
Price
$65
Updated
2021/12/16
Apolloscientific
Product number
PC201380
Product name
5-Bromo-4-fluoropyridin-2-amine
Purity
95%
Packaging
1g
Price
$70
Updated
2021/12/16
Matrix Scientific
Product number
119828
Product name
5-Bromo-4-fluoropyridin-2-amine
Purity
95+%
Packaging
250mg
Price
$98
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB105195
Product name
5-Bromo-4-fluoropyridin-2-amine
Packaging
250mg
Price
$100
Updated
2021/12/16
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5-BroMo-4-fluoropyridin-2-aMine Chemical Properties,Usage,Production

Uses

5-BroMo-4-fluoropyridin-2-amine is a pyridine organic compound used in pharmaceutical synthesis and experiments.

Synthesis

944401-77-8

944401-69-8

A solution of 2-amino-4-fluoropyridine (75.0 g, 0.67 mol) in anhydrous acetonitrile (700 mL) was cooled in an ice-water bath under stirring conditions. Subsequently, N-bromosuccinimide (122.8 g, 0.69 mol) was added in batches. The reaction mixture was stirred continuously for 1 hour at room temperature. After completion of the reaction, the solvent was removed by evaporation under reduced pressure. The residue was washed thoroughly with water (3 x 300 mL) and then dissolved with acetonitrile and again subjected to vacuum evaporation to finally obtain 5-bromo-2-amino-4-fluoropyridine as an off-white solid (124 g, 97% yield).

References

[1] Patent: WO2015/86527, 2015, A1. Location in patent: Page/Page column 108
[2] Patent: WO2015/86526, 2015, A1. Location in patent: Page/Page column 110
[3] ACS Medicinal Chemistry Letters, 2018, vol. 9, # 7, p. 719 - 724
[4] Patent: WO2018/68283, 2018, A1. Location in patent: Paragraph 00252
[5] Patent: WO2018/68282, 2018, A1. Location in patent: Paragraph 00241

5-BroMo-4-fluoropyridin-2-aMine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-BroMo-4-fluoropyridin-2-aMine Suppliers

China 103 India 1 United Kingdom 1 United States 9 Global 114
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
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View Lastest Price from 5-BroMo-4-fluoropyridin-2-aMine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
5-bromo-4-fluoro-pyridin-2-amine 944401-69-8
Price
US $3.00-9.00/KG
Min. Order
0.1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2025-06-26
Career Henan Chemical Co
Product
5-BroMo-4-fluoropyridin-2-aMine 944401-69-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2019-12-31

944401-69-8, 5-BroMo-4-fluoropyridin-2-aMineRelated Search:


  • 5-BroMo-4-fluoropyridin-2-aMine
  • 2-aMino-5-broMo-4-fluoropyridine
  • 5-Bromo-4-fluoro-pyridin-2-ylamine
  • 5-bromo-2-amino-4-fluoropyridine
  • 5-Bromo-4-fluoro-2-pyridinamine
  • 152966
  • 5-bromo-4-fluoropyridine-2-amine
  • 2-Pyridinamine, 5-bromo-4-fluoro-
  • 2-Amino-4-fluoro-5-bromopyridine
  • 944401-69-8