Carbonic Anhydrase IX/XII Inhibitor II(U-104)

ChemicalBook > CAS DataBase List > Carbonic Anhydrase IX/XII Inhibitor II(U-104)

Carbonic Anhydrase IX/XII Inhibitor II(U-104)

Product Name: Carbonic Anhydrase IX/XII Inhibitor II(U-104)
CAS No.: 178606-66-1
Chemical Name: Carbonic Anhydrase IX/XII Inhibitor II(U-104)
Synonyms: U-104;DNAJA4;CS-1653;MSTP104;PRO1472;MST-104 ;SLC-0111;NSC 213841;U-104, >98%;U104(SLC-0111)
CBNumber: CB92630071
Molecular Formula: C13H12FN3O3S
Formula Weight: 309.32
MOL File: 178606-66-1.mol

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Carbonic Anhydrase IX/XII Inhibitor II(U-104) Property

Melting point:: 242-243℃
Density: 1.523±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.: 2-8°C
solubility: DMSO: >15mg/mL
form: powder
pka: 9.94±0.12(Predicted)
color: white to beige

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0374
Product name: U-104
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $117
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0374
Product name: U-104
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $458
Updated: 2024/03/01

Sigma-Aldrich

Product number: HPA041790
Product name: Anti-DNAJA4 antibody produced in rabbit
Purity: Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody
Packaging: 100μL
Price: $580
Updated: 2024/03/01

Sigma-Aldrich

Product number: 215901
Product name: Carbonic Anhydrase IX/XII Inhibitor II, U-104
Purity: The Carbonic Anhydrase IX/XII Inhibitr II, U-104 controls the biological activity of Carbonic Anhydrase IX/XII. This small molecule/inhibitor is primarily used for Cancer applications.
Packaging: 5MG
Price: $130
Updated: 2024/03/01

Sigma-Aldrich

Product number: HPA041790
Product name: Anti-DNAJA4 antibody produced in rabbit
Purity: Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody
Packaging: 25μL
Price: $282
Updated: 2023/06/20

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Carbonic Anhydrase IX/XII Inhibitor II(U-104) Chemical Properties,Usage,Production

Uses

U 104 targets hypoxia-induced carbonic anhydrase IX, which inhibits tumor growth and metastasis.

Biological Activity

u-104 is a novel ureido-sulfonamide inhibitor of carbonic anhydrase ix (caix). tumor volume measurements show important inhibition of primary tumor growth in the mice treated with the u-104 compound compared with vehicle controls. it also has ability to inhibit metastasis formation in the 4t1 experimental metastasis model.yuanmei lou, paul c. mcdonald, arusha oloumi, stephen chia, christina ostlund, ardalan ahmadi, alastair kyle, ulrich auf dem keller, samuel leung, david huntsman, blaise clarke, brent w. sutherland, dawn waterhouse, marcel bally, calvin roskelley, christopher m. overall, andrew minchinton, fabio pacchiano, fabrizio carta, andrea scozzafava, nadia touisni, jean-yves winum, claudiu t. supuran, shoukat dedhar. targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase ix inhibitors. cancer research may 1, 2011 71; 3364

Biochem/physiol Actions

U-104 is an inhibitor of CA IX that binds only to CA IX under hypoxic conditions in vivo. The binding results in significant inhibition of tumor growth and metastasis formation in both spontaneous and experimental models of metastasis. U-104 reduces the medium acidity by inhibiting the catalytic activity of the CA IX. It binds specifically only to hypoxic cells expressing CA IX.

Carbonic Anhydrase IX/XII Inhibitor II(U-104) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Carbonic Anhydrase IX/XII Inhibitor II(U-104) manufacturers

Career Henan Chemical Co

Product: Carbonic Anhydrase IX/XII Inhibitor II(U-104) 178606-66-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20kg
Release date: 2019-09-05

178606-66-1, Carbonic Anhydrase IX/XII Inhibitor II(U-104)Related Search:

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Carbonic Anhydrase IX/XII Inhibitor II(U-104)

U-104

MST-104

4-[[[(4-Fluorophenyl)amino]carbonyl]amino]benzenesulfonamide

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arbonic Anhydrase IX/XII Inhibitor II(U-104)

NSC-213841; MST-104;U104;U 104

4-[[[(4-Fluorophenyl)amino]carbonyl]amino]-benzesulfonamide

4-{[(4'-fluorophenyl)carbamoyl]amino}benzenesulfonamide

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SLC-0111

4-[[[(4-Fluorophenyl)aMino]carbonyl]aMino]-benzenesulfonaMide, NSC 213841

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4-(3-(4-fluorophenyl)ureido)benzenesulfonamide

Anti-DNAJA4 antibody produced in rabbit

DNAJA4

MSTP104

PRO1472

U-104 >=98% (HPLC)

1-(4-Fluorophenyl)-3-(4-sulfamoylphenyl)urea

Carbonic Anhydrase IX/XII Inhibitor II(U-104) USP/EP/BP

U104(SLC-0111)

LM2-4,U 104,CAIX,CAI,CAXII,U104,U-104,exosome,SLC-0111,SLC0111,Carbonate dehydratase,Carbonic Anhydrase,inhibit,SLC 0111,4T1,Inhibitor,CAII

4-{[(4'-fluorophenyl)carbamoyl]amino}benzenesulfonamide

178606-66-1

Inhibitors

Inhibitor