3-(1-ADAMANTYL)-4-METHOXYBENZENEBORONIC ACID

Product Name: 3-(1-ADAMANTYL)-4-METHOXYBENZENEBORONIC ACID
CAS No.: 459423-32-6
Chemical Name: 3-(1-ADAMANTYL)-4-METHOXYBENZENEBORONIC ACID
Synonyms: 3-(1-Adamantyl)-4-methoxyphenylboronicaci;3-Adamant-1-yl-4-methoxybenzeneboronic acid;3-(1-ADAMANTYL)-4-METHOXYPHENYLBORONIC ACID;3-(1-ADAMANTYL)-4-METHOXYBENZENEBORONIC ACID;3- (1-adamantane) -4-methoxyphenylboronic acid;3-(Adamantan-1-yl)-4-methoxybenzeneboronic acid;[3-(adaMantan-1-yl)-4-Methoxyphenyl]boronic acid;3-(Adamantan-1-yl)-4-methoxybenzeneboronicacid96%;3-(1-Adamantyl)-4-methoxybenzeneboronic acid, 96%,;3-(Adamantan-1-yl)-4-methoxybenzeneboronic acid 96%
CBNumber: CB9263525
Molecular Formula: C17H23BO3
Formula Weight: 286.17
MOL File: 459423-32-6.mol

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3-(1-ADAMANTYL)-4-METHOXYBENZENEBORONIC ACID Property

Melting point:: 239-242
Boiling point:: 475.0±55.0 °C(Predicted)
Density: 1.20±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,2-8°C
pka: 8.94±0.10(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C17H23BO3/c1-21-16-3-2-14(18(19)20)7-15(16)17-8-11-4-12(9-17)6-13(5-11)10-17/h2-3,7,11-13,19-20H,4-6,8-10H2,1H3
InChIKey: FPZOBRFHRPQGAA-UHFFFAOYSA-N
SMILES: B(C1=CC=C(OC)C(C23CC4CC(CC(C4)C2)C3)=C1)(O)O

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Safety

Hazard Codes: Xi
Hazard Note: Irritant/Keep Cold
HS Code: 2931900090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: A210003
Product name: 3-(1-Adamantyl)-4-methoxyphenylboronicAcid
Packaging: 25mg
Price: $50
Updated: 2021/12/16

TRC

Product number: A210003
Product name: 3-(1-Adamantyl)-4-methoxyphenylboronicAcid
Packaging: 100mg
Price: $125
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA150079
Product name: 3-(1-Adamantyl)-4-methoxyphenylboronicacid
Packaging: 50mg
Price: $63
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA150079
Product name: 3-(1-Adamantyl)-4-methoxyphenylboronicacid
Packaging: 100mg
Price: $110
Updated: 2021/12/16

AK Scientific

Product number: X0816
Product name: 3-(1-Adamantyl)-4-methoxyphenylboronicacid
Packaging: 250mg
Price: $204
Updated: 2021/12/16

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3-(1-ADAMANTYL)-4-METHOXYBENZENEBORONIC ACID Chemical Properties,Usage,Production

Uses

Promotes the ortho hydroxalkylation of phenols by aldehyde. Used as reagent in the proection of thiols as cyclic boronates. This has been utilized to trap cis thiols in oder to prevent over oxidation during dihydroxylation reaction by osmium (4)oxide.

Synthesis

121-43-7

104224-63-7

459423-32-6

Step B. Synthesis of 3-(1-adamantyl)-4-methoxyphenylboronic acid Example 2: In a 1L three-necked flask equipped with a stirrer, reflux condenser, and dropping funnel, a mixture of 8 g (0.33 mol) of magnesium shavings and 200 mL of anhydrous tetrahydrofuran was added. Subsequently 8 g (0.19 mol) of crushed anhydrous lithium chloride was added. The air in the flask was replaced with argon and subsequent operations were carried out under an inert atmosphere. Under vigorous stirring, 11 g (5 mL, 0.06 mol) of 1,2-dibromoethane was added all at once. After the vigorous reaction subsided, 50 g (0.16 mol) of 2-(1-adamantyl)-4-bromoanisole dissolved in 400 mL of tetrahydrofuran was slowly added dropwise, with the rate of titration controlled to maintain a slight reflux. After dropwise addition, stirring was continued and heated to slow reflux for 30 minutes. Stirring was stopped and the resulting Grignard reagent was decanted from the residual magnesium into a conical flask that had been pre-flushed with argon and cooled to 0°C and kept sealed for 2 hours. In another 1L three-necked flask, 33 g (36 mL, 0.35 mol) of trimethyl borate and 100 mL of anhydrous tetrahydrofuran were added and mixed with stirring. The resulting solution was cooled to 0-5 °C (ice-water bath) and the pre-prepared Grignard reagent was added dropwise over 10 min under vigorous stirring. The reaction mixture was allowed to stand overnight (16 hours) in a refrigerator at 0-5°C. Subsequently, cooling was withdrawn and 50 mL of hydrochloric acid (diluted in 50 mL of water) was added under vigorous stirring to quench the reaction. The mixture was transferred to a partitioning funnel for layering. The aqueous layer was diluted with 200 mL of water and extracted twice with 100 mL of diethyl ether. The organic phases were combined, dried with anhydrous sodium sulfate, and concentrated under reduced pressure to remove the solvent (water bath temperature about 50°C). The residue was treated with 200 mL of ethyl acetate and allowed to stand overnight in a refrigerator. The precipitate was collected by filtration and dried at 100 °C to give 30 g of 3-(1-adamantyl)-4-methoxyphenylboronic acid (68% yield) with a melting point of 300 °C. Example 10: The reaction was carried out according to the method described in Example 2, with the difference that the reaction of 3-(1-adamantyl)-4-methoxyphenylmagnesium bromide solution with trimethyl borate was carried out at -70°C, to ultimately obtain 30.6 g of 3-(1-adamantyl)-4-methoxyphenylboronic acid (69% yield).

References

[1] Russian Journal of General Chemistry, 2010, vol. 80, # 4, p. 868 - 869
[2] Russian Journal of General Chemistry, 2010, vol. 80, # 4, p. 868 - 869
[3] Patent: US2010/160677, 2010, A1. Location in patent: Page/Page column 3-4

3-(1-ADAMANTYL)-4-METHOXYBENZENEBORONIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(1-ADAMANTYL)-4-METHOXYBENZENEBORONIC ACID Suppliers

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View Lastest Price from 3-(1-ADAMANTYL)-4-METHOXYBENZENEBORONIC ACID manufacturers

Honest Joy Holdings Limited

Product: 3-(1-Adamantyl)-4-methoxyphenylboronic acid 459423-32-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.9%
Supply Ability: 100 tons
Release date: 2022-01-17

Career Henan Chemical Co

Product: 3-(1-ADAMANTYL)-4-METHOXYBENZENEBORONIC ACID 459423-32-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 150KG
Release date: 2019-07-09

459423-32-6, 3-(1-ADAMANTYL)-4-METHOXYBENZENEBORONIC ACIDRelated Search:

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459423-32-6

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blocks

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