2-aMino-5-cyanobenzoic acid
- Product Name
- 2-aMino-5-cyanobenzoic acid
- CAS No.
- 99767-45-0
- Chemical Name
- 2-aMino-5-cyanobenzoic acid
- Synonyms
- 2-aMino-5-cyanobenzoic acid;Benzoic acid, 2-amino-5-cyano-;2-Amino-5-cyanobenzoic acid≥ 97% (HPLC)
- CBNumber
- CB92638486
- Molecular Formula
- C8H6N2O2
- Formula Weight
- 162.15
- MOL File
- 99767-45-0.mol
2-aMino-5-cyanobenzoic acid Property
- Boiling point:
- 389.3±37.0 °C(Predicted)
- Density
- 1.41±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 4.38±0.10(Predicted)
- Appearance
- Off-white to yellow Solid
Safety
- RIDADR
- 2811
- HazardClass
- 6.1
- PackingGroup
- Ⅲ
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- A605410
- Product name
- 2-amino-5-cyanobenzoicacid
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- CS-W005229
- Product name
- 2-Amino-5-cyanobenzoicacid
- Packaging
- 5g
- Price
- $367
- Updated
- 2021/12/16
- Product number
- CS-W005229
- Product name
- 2-Amino-5-cyanobenzoicacid
- Packaging
- 1g
- Price
- $87
- Updated
- 2021/12/16
- Product number
- FA74950
- Product name
- 2-Amino-5-cyanobenzoic acid
- Packaging
- 1g
- Price
- $240
- Updated
- 2021/12/16
- Product number
- 4657-1-58
- Product name
- 2-Amino-5-cyanobenzoic acid
- Packaging
- 1g
- Price
- $260
- Updated
- 2021/12/16
2-aMino-5-cyanobenzoic acid Chemical Properties,Usage,Production
Chemical Properties
Pale yellow solid
Synthesis
159847-81-1
99767-45-0
General procedure for the synthesis of 2-amino-5-cyanobenzoic acid from methyl 2-amino-5-cyanobenzoate: to a methanolic (200 mL) suspension of methyl 2-amino-5-cyanobenzoate (9.55 g, 54.2 mmol) was added an aqueous sodium hydroxide solution (30 mL, 6.0 M, 180 mmol). The reaction mixture was stirred at room temperature and a homogeneous solution was formed after 1 hour. After 27.5 hours of reaction, the solvent was removed by evaporation under reduced pressure and the residue was dissolved in water (300 mL). The resulting aqueous phase was washed with dichloromethane (2 x 200 mL) and subsequently acidified to acidity with concentrated hydrochloric acid (1 L). The product was extracted with ethyl acetate (500 mL), the organic phases were combined and dried over anhydrous magnesium sulfate. The organic phase was concentrated under reduced pressure to give 8.57 g (97.5% yield) of yellow solid product, which could be used in subsequent reactions without further purification.
References
[1] Patent: WO2004/18428, 2004, A1. Location in patent: Page 347
[2] Patent: WO2014/93869, 2014, A1. Location in patent: Paragraph 0140
[3] Journal of Medicinal Chemistry, 2014, vol. 57, # 20, p. 8608 - 8621
[4] Patent: WO2004/18428, 2004, A1. Location in patent: Page 370
[5] Patent: WO2004/18414, 2004, A2. Location in patent: Page 136
2-aMino-5-cyanobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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