2-(trifluoroMethyl)pyriMidin-5-ylboronic acid

Product Name: 2-(trifluoroMethyl)pyriMidin-5-ylboronic acid
CAS No.: 1308298-23-8
Chemical Name: 2-(trifluoroMethyl)pyriMidin-5-ylboronic acid
Synonyms: 4-Trifluormethyl-phenothiazin;2-(Trifluoromethyl)pyrimidine-5-boronic Acid;2-(trifluoroMethyl)pyriMidin-5-ylboronic acid;[2-(Trifluoromethyl)-5-pyrimidinyl]boronic acid;B-[2-(Trifluoromethyl)-5-pyrimidinyl]boronic acid;Boronic acid, B-[2-(trifluoromethyl)-5-pyrimidinyl]-;[2-(trifluoromethyl)pyrimidin-5-yl]boronic acid - [T18540]
CBNumber: CB92639029
Molecular Formula: C5H4BF3N2O2
Formula Weight: 191.9
MOL File: 1308298-23-8.mol

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2-(trifluoroMethyl)pyriMidin-5-ylboronic acid Property

Boiling point:: 236.7±50.0 °C(Predicted)
Density: 1.53±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: solid
pka: 4.46±0.11(Predicted)
Appearance: White to light yellow Solid
InChI: InChI=1S/C5H4BF3N2O2/c7-5(8,9)4-10-1-3(2-11-4)6(12)13/h1-2,12-13H
InChIKey: OEZMIKKBMMAABO-UHFFFAOYSA-N
SMILES: B(C1=CN=C(C(F)(F)F)N=C1)(O)O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: T897658
Product name: (2-(Trifluoromethyl)pyrimidin-5-yl)boronicacid
Packaging: 50mg
Price: $130
Updated: 2021/12/16

ChemScene

Product number: CS-D0474
Product name: 2-(trifluoromethyl)pyrimidin-5-ylboronicacid
Purity: 98.75%
Packaging: 250mg
Price: $179
Updated: 2021/12/16

ChemScene

Product number: CS-D0474
Product name: 2-(trifluoromethyl)pyrimidin-5-ylboronicacid
Purity: 98.75%
Packaging: 1g
Price: $445
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BOR0011633
Product name: (2-(TRIFLUOROMETHYL)PYRIMIDIN-5-YL)BORONIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $459.8
Updated: 2021/12/16

Synthonix

Product number: T18540
Product name: [2-(trifluoromethyl)pyrimidin-5-yl]boronicacid
Purity: 97.0%
Packaging: 1g
Price: $680
Updated: 2021/12/16

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2-(trifluoroMethyl)pyriMidin-5-ylboronic acid Chemical Properties,Usage,Production

Synthesis

799557-86-1

5419-55-6

1308298-23-8

To a hexane solution of 0.5 M n-butyllithium (1.7 mL, 2.4 mmol) was added slowly and dropwise a tetrahydrofuran (THF, 10 mL) solution of 5-bromo-2-trifluoromethylpyrimidine (700.6 mg, 3.1 mmol) and triisopropyl borate (1.1 mL, 4.7 mmol) at -78°C. The reaction mixture was stirred continuously at -78 °C for 2 h. The reaction was subsequently quenched with water. The solvent was removed by distillation under reduced pressure and the residue was extracted with ether (2 x 40 mL). After separation of the aqueous layer, the pH was adjusted to 6 with 1N hydrochloric acid and extracted with ethyl acetate (EA, 3 x 40 mL). The organic layers were combined, washed with saturated saline, dried over anhydrous sodium sulfate, and concentrated to obtain the target product 2-(trifluoromethyl)pyrimidin-5-ylboronic acid (400 mg, 67.2% yield) as a white solid. Liquid chromatography-mass spectrometry (LC-MS) analysis showed a retention time of 0.66 min and a molecular ion peak (MH+) of 193.

References

[1] Patent: WO2016/44792, 2016, A1. Location in patent: Page/Page column 105; 106

2-(trifluoroMethyl)pyriMidin-5-ylboronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(trifluoroMethyl)pyriMidin-5-ylboronic acid Suppliers

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View Lastest Price from 2-(trifluoroMethyl)pyriMidin-5-ylboronic acid manufacturers

Career Henan Chemical Co

Product: 2-(trifluoroMethyl)pyriMidin-5-ylboronic acid 1308298-23-8
Price: US $5.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2020-01-12

1308298-23-8, 2-(trifluoroMethyl)pyriMidin-5-ylboronic acidRelated Search:

2-(trifluoroMethyl)pyriMidin-5-ylboronic acid

[2-(Trifluoromethyl)-5-pyrimidinyl]boronic acid

4-Trifluormethyl-phenothiazin

2-(Trifluoromethyl)pyrimidine-5-boronic Acid

Boronic acid, B-[2-(trifluoromethyl)-5-pyrimidinyl]-

B-[2-(Trifluoromethyl)-5-pyrimidinyl]boronic acid

[2-(trifluoromethyl)pyrimidin-5-yl]boronic acid - [T18540]

1308298-23-8

C5H4BF3N2O2