1-(4-BroMo-2-fluorophenyl)cyclopropanecarboxylic acid
- Product Name
- 1-(4-BroMo-2-fluorophenyl)cyclopropanecarboxylic acid
- CAS No.
- 872422-15-6
- Chemical Name
- 1-(4-BroMo-2-fluorophenyl)cyclopropanecarboxylic acid
- Synonyms
- 1-(4-BroMo-2-fluorophenyl)cyclopropanecarboxylic acid;1-(4-bromo-2-fluorophenyl)-сyclopropanecarboxylic acid;Cyclopropanecarboxylic acid, 1-(4-bromo-2-fluorophenyl)-;1-(4-BroMo-2-fluorophenyl)cyclopropane-1-carboxylic acid
- CBNumber
- CB92641006
- Molecular Formula
- C10H8BrFO2
- Formula Weight
- 259.07
- MOL File
- 872422-15-6.mol
1-(4-BroMo-2-fluorophenyl)cyclopropanecarboxylic acid Property
- Boiling point:
- 350.9±42.0 °C(Predicted)
- Density
- 1.744±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 3.81±0.20(Predicted)
- Appearance
- Off-white to light yellow Solid
Safety
- HS Code
- 2916200090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B692978
- Product name
- 1-(4-Bromo-2-fluorophenyl)cyclopropane-1-carboxylicacid
- Packaging
- 2.5g
- Price
- $395
- Updated
- 2021/12/16
- Product number
- PC901560
- Product name
- 1-(4-Bromo-2-fluorophenyl)cyclopropanecarboxylicacid
- Purity
- >98%
- Packaging
- 1g
- Price
- $416
- Updated
- 2021/12/16
- Product number
- HCH0106293
- Product name
- 1-(4-BROMO-2-FLUOROPHENYL)CYCLOPROPANECARBOXYLIC ACID
- Purity
- 98.00%
- Packaging
- 5MG
- Price
- $497.43
- Updated
- 2021/12/16
- Product number
- 092683
- Product name
- 1-(4-Bromo-2-fluorophenyl)-cyclopropanecarboxylic acid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $756
- Updated
- 2021/12/16
- Product number
- PC901560
- Product name
- 1-(4-Bromo-2-fluorophenyl)cyclopropanecarboxylicacid
- Purity
- >98%
- Packaging
- 250mg
- Price
- $192
- Updated
- 2021/12/16
1-(4-BroMo-2-fluorophenyl)cyclopropanecarboxylic acid Chemical Properties,Usage,Production
Synthesis
114897-91-5
107-04-0
872422-15-6
Step 1. Sodium hydroxide (50% aqueous solution, 5.71 mL, 0.149 mol) was added to a mixture of 4-bromo-2-fluorobenzyl cyanide (3.16 g, 0.0145 mol), benzyltriethylammonium chloride (0.26 g, 0.0011 mol), and 1-bromo-2-chloroethane (2.51 mL, 0.0302 mol), and the reaction was allowed to proceed at 50 °C for for 10 hours. After completion of the reaction, the mixture was poured into ice water (50 mL) and extracted with ether (2 x 50 mL). The organic phases were combined, washed with brine (30 mL), dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 2.88 g of brown solid. The formation of the nitrile intermediate was confirmed by 1H-NMR. Step 2. 50% aqueous sodium hydroxide solution (3.8 mL) and ethylene glycol (20 mL) were added to the residue obtained above, and the mixture was heated to 100 °C and stirred overnight. After the reaction was completed, the mixture was poured into water (50 mL) and washed with ether (2 x 50 mL). The aqueous layer was cooled with an ice bath and acidified slowly by adding 6N hydrochloric acid to pH=2. The product was extracted with ethyl acetate (2 x 100 mL), dried over anhydrous magnesium sulfate and concentrated to give 1.634 g (70% yield) of the target product 1-(4-bromo-2-fluorophenyl)cyclopropanecarboxylic acid. The structure of the product was confirmed by 1H NMR.
References
[1] Patent: US2005/288338, 2005, A1. Location in patent: Page/Page column 34
[2] Patent: WO2006/20598, 2006, A2. Location in patent: Example 145.1
1-(4-BroMo-2-fluorophenyl)cyclopropanecarboxylic acid Preparation Products And Raw materials
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