tert-butyl 4-oxo-3,4,5,6-tetrahydropyrido[3,4-d]pyriMidine-7(8H)-carboxylate

Product Name: tert-butyl 4-oxo-3,4,5,6-tetrahydropyrido[3,4-d]pyriMidine-7(8H)-carboxylate
CAS No.: 1142188-60-0
Chemical Name: tert-butyl 4-oxo-3,4,5,6-tetrahydropyrido[3,4-d]pyriMidine-7(8H)-carboxylate
Synonyms: Seco-Duocarmycin TM;UHNCQJLEINZUNT-UHFFFAOYSA-N;7-Boc-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one;7-Boc-4-hydroxy-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine;tert-butyl 4-oxo-3H,4H,5H,6H,7H,8H-pyrido[3,4-d]pyrimidine-7-carboxylate;tert-butyl 4-hydroxy-5,8-dihydropyrido[3,4-d]pyrimidine-7(6H)-carboxylate;TERT-BUTYL 4-HYDROXY-5,6-DIHYDROPYRIDO[3,4-D]PYRIMIDINE-7(8H)-CARBOXYLATE;tert-Butyl 4-oxo-4,5,6,8-tetrahydropyrido[3,4-d]pyrimidine-7(3H)-carboxylate;tert-butyl 4-oxo-3,4,5,6-tetrahydropyrido[3,4-d]pyriMidine-7(8H)-carboxylate;4-Hydroxy-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid tert-butyl ester
CBNumber: CB92646021
Molecular Formula: C12H17N3O3
Formula Weight: 251.28
MOL File: 1142188-60-0.mol

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tert-butyl 4-oxo-3,4,5,6-tetrahydropyrido[3,4-d]pyriMidine-7(8H)-carboxylate Property

Boiling point:: 389.1±52.0 °C(Predicted)
Density: 1.30±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 1.10±0.20(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C12H17N3O3/c1-12(2,3)18-11(17)15-5-4-8-9(6-15)13-7-14-10(8)16/h7H,4-6H2,1-3H3,(H,13,14,16)
InChIKey: UHNCQJLEINZUNT-UHFFFAOYSA-N
SMILES: C1NC(=O)C2CCN(C(OC(C)(C)C)=O)CC=2N=1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: T204943
Product name: tert-Butyl4-Hydroxy-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
Packaging: 50mg
Price: $285
Updated: 2021/12/16

AK Scientific

Product number: 5109EM
Product name: Tert-butyl4-hydroxy-5,6-dihydropyrido[3,4-D]pyrimidine-7(8H)-carboxylate
Packaging: 1g
Price: $863
Updated: 2021/12/16

Ambeed

Product number: A187068
Product name: tert-Butyl4-hydroxy-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
Purity: 95%
Packaging: 250mg
Price: $109
Updated: 2021/12/16

Ambeed

Product number: A187068
Product name: tert-Butyl4-hydroxy-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
Purity: 95%
Packaging: 1g
Price: $236
Updated: 2021/12/16

Crysdot

Product number: CD11347541
Product name: tert-Butyl4-hydroxy-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
Purity: 95+%
Packaging: 1g
Price: $584
Updated: 2021/12/16

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tert-butyl 4-oxo-3,4,5,6-tetrahydropyrido[3,4-d]pyriMidine-7(8H)-carboxylate Chemical Properties,Usage,Production

Synthesis

62458-96-2

24424-99-5

1142188-60-0

Preparation of Compound 12F: 7-Benzyl-5,6,7,8-tetrahydropyrido[3,4-D]pyrimidin-4(3H)-one (Compound 12E, 2.5 g, 10.4 mmol), 10% Pd/C (0.5 g) and di-tert-butyl dicarbonate (2.7 g, 12.4 mmol) were dissolved in methanol (40 mL). The reaction mixture was stirred overnight under hydrogen atmosphere (0.5 Mpa pressure). The reaction process was monitored by thin layer chromatography (TLC, unfolding agent ratio dichloromethane/methanol = 10:1). After completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to afford purified tert-butyl 4-hydroxy-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate (Compound 12F, 2.6 g, 100% yield) as a yellow solid.

References

[1] Patent: US2016/75708, 2016, A1. Location in patent: Paragraph 0086; 0091
[2] Patent: KR2015/139962, 2015, A. Location in patent: Paragraph 0118-0119; 0129-0130

tert-butyl 4-oxo-3,4,5,6-tetrahydropyrido[3,4-d]pyriMidine-7(8H)-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from tert-butyl 4-oxo-3,4,5,6-tetrahydropyrido[3,4-d]pyriMidine-7(8H)-carboxylate manufacturers

Career Henan Chemical Co

Product: 2-Methyl-2-propanyl 4-oxo-4,5,6,8-tetrahydropyrido[3,4-d]pyrimidine-7(1H)-carboxylate 1142188-60-0
Price: US $1.00/GK
Min. Order: 1g
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-02-07

1142188-60-0, tert-butyl 4-oxo-3,4,5,6-tetrahydropyrido[3,4-d]pyriMidine-7(8H)-carboxylateRelated Search:

tert-butyl 4-oxo-3,4,5,6-tetrahydropyrido[3,4-d]pyriMidine-7(8H)-carboxylate

TERT-BUTYL 4-HYDROXY-5,6-DIHYDROPYRIDO[3,4-D]PYRIMIDINE-7(8H)-CARBOXYLATE

Seco-Duocarmycin TM

7-Boc-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one

tert-Butyl 4-oxo-4,5,6,8-tetrahydropyrido[3,4-d]pyrimidine-7(3H)-carboxylate

UHNCQJLEINZUNT-UHFFFAOYSA-N

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Pyrido[3,4-d]pyrimidine-7(3H)-carboxylic acid, 4,5,6,8-tetrahydro-4-oxo-, 1,1-dimethylethyl ester

4-Hydroxy-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid tert-butyl ester

tert-butyl 4-oxo-3H,4H,5H,6H,7H,8H-pyrido[3,4-d]pyrimidine-7-carboxylate

tert-butyl 4-hydroxy-5,8-dihydropyrido[3,4-d]pyrimidine-7(6H)-carboxylate

7-Boc-4-hydroxy-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine

1142188-60-0