ChemicalBook > CAS DataBase List > Bexagliflozin

Bexagliflozin

Product Name
Bexagliflozin
CAS No.
1118567-05-7
Chemical Name
Bexagliflozin
Synonyms
CS-250;CS-2165;EGT1442;THR1442;THR 1442;THR-1442;EGT0001442;EGT-0001442;EGT 0001442;Bexgliflozin
CBNumber
CB92650633
Molecular Formula
C24H29ClO7
Formula Weight
464.94
MOL File
1118567-05-7.mol
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Bexagliflozin Property

Boiling point:
671.0±55.0 °C(Predicted)
Density 
1.41
storage temp. 
Store at -20°C
solubility 
DMSO:100.0(Max Conc. mg/mL);215.08(Max Conc. mM)
form 
A crystalline solid
pka
13.23±0.70(Predicted)
InChIKey
BTCRKOKVYTVOLU-IZSIRFNDNA-N
SMILES
[C@H]1(C2C=C(CC3C=CC(OCCOC4CC4)=CC=3)C(Cl)=CC=2)[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 |&1:0,22,24,26,28,r|
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21359
Product name
EGT-1442
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
21359
Product name
EGT-1442
Purity
≥95%
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
21359
Product name
EGT-1442
Purity
≥95%
Packaging
10mg
Price
$243
Updated
2024/03/01
Cayman Chemical
Product number
21359
Product name
EGT-1442
Purity
≥95%
Packaging
25mg
Price
$533
Updated
2024/03/01
TRC
Product number
B336785
Product name
Bexagliflozin3
Packaging
10mg
Price
$310
Updated
2021/12/16
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Bexagliflozin Chemical Properties,Usage,Production

Description

EGT-1442 is a potent, selective sodium glucose co-transporter 2 (SGLT2) inhibitor with IC50 values of 5.6 μM and 2 nM for human SGLT1 and SGLT2, respectively. It produces a stable urinary excretion of glucose in rats and dogs with ED50 values of 0.38 and 0.09 mg/kg, respectively, and reduces HbA(1c) and blood glucose in db/db mice in a concentration dependent manner.

Uses

Bexagliflozin, also known as EGT1442, is a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA(1c) levels in db/db mice and prolongs the survival of stroke-prone rats. EGT1442 showed favorable properties both in vitro and in vivo and could be beneficial to the management of type 2 diabetic patients.

Definition

ChEBI: Bexagliflozin is a C-glycosyl comprising of beta-D-glucose in which the anomeric hydroxy group is replaced by a 4-chloro-3-({4-[2-(cyclopropyloxy)ethoxy]phenyl}methyl)phenyl group. It is a sodium-glucose co-transporter 2 (SGLT2) inhibitor indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. It has a role as a sodium-glucose transport protein subtype 2 inhibitor, a hypoglycemic agent and an antihypertensive agent. It is a C-glycosyl compound, an aromatic ether, a member of monochlorobenzenes, a diether and a member of cyclopropanes.

Mechanism of action

Bexagliflozin is a highly selective inhibitor of sodium-glucose cotransporter protein 2 (SGLT2), which cotransports sodium and glucose from the filtrate to the epithelium of the proximal renal tubule, thereby lowering the tubular glucose reabsorption threshold, reducing renal glucose reabsorption, and increasing urinary glucose excretion without affecting insulin levels.

Bexagliflozin Preparation Products And Raw materials

Raw materials

Preparation Products

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Bexagliflozin Suppliers

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View Lastest Price from Bexagliflozin manufacturers

Jinan Million Pharmaceutical Co., Ltd
Product
Bexagliflozin 1118567-05-7
Price
US $2.00/kg
Min. Order
0.10000000149011612kg
Purity
99%
Supply Ability
200KG
Release date
2023-09-11
R&D Scientific Inc.
Product
Bexagliflozin 1118567-05-7
Price
US $380.00/g
Min. Order
1g
Purity
99
Supply Ability
50 Kg
Release date
2024-02-22
Career Henan Chemical Co
Product
EGT1442 1118567-05-7
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-23

1118567-05-7, BexagliflozinRelated Search:


  • EGT1442
  • (1S)-1,5-Anhydro-1-C-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-D-glucitol
  • Bexagliflozin
  • EGT1442(Bexagliflozin,THR1442)
  • Bexagliflozin，EGT1442
  • CS-2165
  • EGT 0001442
  • EGT0001442
  • EGT-0001442
  • EGT1442; THR1442; EGT0001442; EGT-1442; THR-1442; EGT-0001442; EGT 1442; THR 1442; EGT 0001442
  • THR 1442
  • THR1442
  • THR-1442
  • CS-250
  • Bexagliflozin(THR1442,EGT1442)|
  • BEXAGLIFLOZIN;EGT-1442;THR1442;EGT0001442;EGT-1442;THR-1442;EGT-0001442;EGT 1442;THR 1442;EGT 0001442
  • Bexagliflozin (THR1442)
  • D-Glucitol, 1,5-anhydro-1-C-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-, (1S)-
  • Bexagliflozin3
  • Bexgliflozin
  • (2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-(2-cyclopropoxyethoxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
  • Bexagliflozin Impurity 1
  • Bexgliflozin Impurity 1
  • Bexgliflozin (EGT1442)
  • 1118567-05-7