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LY2801653

Product Name
LY2801653
CAS No.
1206799-15-6
Chemical Name
LY2801653
Synonyms
CS-685;NSC32624;LY2801653;NSC 32624;NSC-32624;Merestinib;MET inhibitor;LY2801653(Merestinib);Merestinib(LY 2801653);MET INHIBITOR; LY2801653; LY-2801653; LY 2801653; MERESTINIB
CBNumber
CB92650875
Molecular Formula
C30H22F2N6O3
Formula Weight
552.53
MOL File
1206799-15-6.mol
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LY2801653 Property

Boiling point:
795.3±60.0 °C(Predicted)
Density 
1.42±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≥27.65 mg/mL in DMSO; insoluble in H2O; ≥5.02 mg/mL in EtOH with gentle warming and ultrasonic
form 
solid
pka
10.83±0.70(Predicted)
InChI
InChI=1S/C30H22F2N6O3/c1-17-3-9-23(30(40)38(17)22-7-4-20(31)5-8-22)29(39)36-21-6-10-27(25(32)12-21)41-28-11-18-16-35-37(2)26(18)13-24(28)19-14-33-34-15-19/h3-16H,1-2H3,(H,33,34)(H,36,39)
InChIKey
QHADVLVFMKEIIP-UHFFFAOYSA-N
SMILES
C1(=O)N(C2=CC=C(F)C=C2)C(C)=CC=C1C(NC1=CC=C(OC2C(C3=CNN=C3)=CC3=C(C=2)C=NN3C)C(F)=C1)=O
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H351Suspected of causing cancer

H360May damage fertility or the unborn child

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P281Use personal protective equipment as required.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

P314Get medical advice/attention if you feel unwell.

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
25978
Product name
LY2801653
Purity
≥98%
Packaging
1mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
25978
Product name
LY2801653
Purity
≥98%
Packaging
5mg
Price
$180
Updated
2024/03/01
Cayman Chemical
Product number
25978
Product name
LY2801653
Purity
≥98%
Packaging
10mg
Price
$330
Updated
2024/03/01
Cayman Chemical
Product number
25978
Product name
LY2801653
Purity
≥98%
Packaging
50mg
Price
$893
Updated
2024/03/01
ApexBio Technology
Product number
A3573
Product name
LY2801653
Packaging
100mg
Price
$900
Updated
2021/12/16
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LY2801653 Chemical Properties,Usage,Production

Description

LY2801653 is an orally bioavailable MET kinase inhibitor (Ki = 2 nM). It also inhibits MST1R, Axl, MNK1/2, FLT3, DDR1, and DDR2 (IC50s = 11, 2, 7, 7, 0.1, and 7 nM, respectively, in a cell-based assay). It inhibits MET autophosphorylation stimulated by hepatocyte growth factor (HGF) in H460 and S114 cells (IC50s = 35.2 and 59.2 nM, respectively) and inhibits growth of Ba/F3 cells transfected with MET-activating mutations (IC50s = 12-248 nM). LY2801653 (0.01-10 μM) completely blocks cell scattering induced by HGF in DU145 cells. It reduces tumor growth in MET autocrine (U-87MG) and MET over-expression (H441) mouse xenograft models when administered at doses of 4 and 12 mg/kg.

Description

MET is a tyrosine kinase that leads to downstream activation of several pathways including RAS and MAPK.?As a result, it is quite possible that MET inhibition can be active in RAS mutant tumors and maybe associated with EGFR resistance in NSCLC.?Two MET inhibitors, tivantinib and onartuzumab, have been examined in KRAS mutant NSCLC with others in clinical trials at this time.

Clinical Use

Preclinical testing also has shown merestinib to inhibit several other receptor tyrosine oncokinases including MST1R, FLT3, AXL, MERTK, TEK, ROS1, and NTRK1/2/3.

target

c-MET

References

[1] yan s b et al. , ly2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against met, mst1r, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models. invest new drugs. 2012, 31: 833-844.

LY2801653 Preparation Products And Raw materials

Raw materials

Preparation Products

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LY2801653 Suppliers

China 106 India 1 United Kingdom 1 United States 11 Global 119
Wuhan Bo Jin Biotechnology Co.,Ltd.
Tel
18164232327
Email
2709603029@qq.com
Country
China
ProdList
291
Advantage
58
Anqing Benro pharmachem Technology Co.,Ltd.
Tel
05565209906 15391842992
Email
794263564@qq.com
Country
China
ProdList
111
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2923
Advantage
55
Suzhou Ryan Pharmaceutical Technology Co., Ltd.
Tel
0512-68780025,68780026 18962125825
Email
sales@ryanchem.com
Country
China
ProdList
161
Advantage
62
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9452
Advantage
58
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax
+86-27-87599188
Country
China
ProdList
1494
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7553
Advantage
61
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
18521735133 18521732826;
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25015
Advantage
65
Shanghai Jiyi Biological Technology Co., LTD
Tel
021-54135696 18516235431
Fax
50815371
Email
shgegenetech@163.com
Country
China
ProdList
986
Advantage
55
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4863
Advantage
58
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View Lastest Price from LY2801653 manufacturers

Career Henan Chemical Co
Product
LY2801653 1206799-15-6
Price
US $1.00/KG
Min. Order
1KG
Purity
97%-99.9%
Supply Ability
100kg
Release date
2019-12-25

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  • 1206799-15-6
  • C30H22F2N6O3
  • API