6-broMo-4-chloro-7-Methoxy-quinoline
Application- Product Name
- 6-broMo-4-chloro-7-Methoxy-quinoline
- CAS No.
- 476660-71-6
- Chemical Name
- 6-broMo-4-chloro-7-Methoxy-quinoline
- Synonyms
- 6-broMo-4-chloro-7-Methoxy-quinoline;Quinoline, 6-bromo-4-chloro-7-methoxy-
- CBNumber
- CB92651014
- Molecular Formula
- C10H7BrClNO
- Formula Weight
- 272.53
- MOL File
- 476660-71-6.mol
6-broMo-4-chloro-7-Methoxy-quinoline Property
- Boiling point:
- 348.9±37.0 °C(Predicted)
- Density
- 1.613±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 3.10±0.30(Predicted)
- Appearance
- Light brown to brown Solid
- InChI
- InChI=1S/C10H7BrClNO/c1-14-10-5-9-6(4-7(10)11)8(12)2-3-13-9/h2-5H,1H3
- InChIKey
- UZQYUZCQWPAWIL-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC(Br)=C(OC)C=2)C(Cl)=CC=1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0041246
- Product name
- 6-Bromo-4-chloro-7-methoxyquinoline
- Purity
- 97.83%
- Packaging
- 250mg
- Price
- $63
- Updated
- 2021/12/16
- Product number
- CS-0041246
- Product name
- 6-Bromo-4-chloro-7-methoxyquinoline
- Purity
- 97.83%
- Packaging
- 1g
- Price
- $157
- Updated
- 2021/12/16
- Product number
- 5990DA
- Product name
- 6-Bromo-4-chloro-7-methoxyquinoline
- Packaging
- 100mg
- Price
- $376
- Updated
- 2021/12/16
- Product number
- CS-0041246
- Product name
- 6-Bromo-4-chloro-7-methoxyquinoline
- Purity
- 97.83%
- Packaging
- 5g
- Price
- $497
- Updated
- 2021/12/16
- Product number
- CS-0041246
- Product name
- 6-Bromo-4-chloro-7-methoxyquinoline
- Purity
- 97.83%
- Packaging
- 10g
- Price
- $984
- Updated
- 2021/12/16
6-broMo-4-chloro-7-Methoxy-quinoline Chemical Properties,Usage,Production
Application
6-Bromo-4-chloro-7-methoxyquinoline can be used as a pharmaceutical synthesis intermediate.
Synthesis
1361235-54-2
476660-71-6
General procedure for the synthesis of 6-bromo-4-chloro-7-methoxyquinolin-4-ol from 6-bromo-7-methoxyquinolin-4-ol: 6-bromo-7-methoxyquinolin-4-ol (4.17 g, 16.4 mmol) was dissolved in phosphorus trichloride (8 mL, 82 mmol) and the reaction was stirred for 1 h at 110 °C. The reaction was carried out in aqueous solution of saturated sodium carbonate. Upon completion of the reaction, the mixture was cooled to room temperature and slowly poured into ice-cooled saturated aqueous sodium carbonate solution with stirring. The solid product in the resulting suspension was collected by filtration, washed well with water and subsequently dried under vacuum overnight to afford the target compound 6-bromo-4-chloro-7-methoxyquinoline (4.6 g, 16 mmol, 97% yield).LCMS assay: retention time (RT) = 1.18 min, mass spectrum (ESI+) m/z: 272, 274 [M+H] +.
References
[1] Patent: WO2016/169989, 2016, A1. Location in patent: Page/Page column 54; 55
[2] Patent: WO2017/46036, 2017, A1. Location in patent: Page/Page column 50
[3] Patent: TWI609011, 2017, B. Location in patent: Page/Page column 66; 67
[4] Patent: EP2680844, 2016, B1. Location in patent: Paragraph 0123
[5] Patent: TW2018/8946, 2018, A. Location in patent: Page/Page column 56; 57
6-broMo-4-chloro-7-Methoxy-quinoline Preparation Products And Raw materials
Raw materials
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View Lastest Price from 6-broMo-4-chloro-7-Methoxy-quinoline manufacturers
- Product
- 6-broMo-4-chloro-7-Methoxy-quinoline 476660-71-6
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- ask
- Release date
- 2019-12-19