ChemicalBook > CAS DataBase List > 1-(4-Chlorophenyl)-3-[3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl]urea

1-(4-Chlorophenyl)-3-[3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl]urea

Product Name
1-(4-Chlorophenyl)-3-[3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl]urea
CAS No.
877202-74-9
Chemical Name
1-(4-Chlorophenyl)-3-[3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl]urea
Synonyms
PSNCBAM 1;PSNCBAM-1 >=98% (HPLC);PSNCBAM-1, 10 mM in DMSO;PSNCBAM-1,PSNCBAM1,inhibit,Inhibitor,Cannabinoid Receptor;1-(4-Chlorophenyl)-3-[3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl]urea;N-(4-Chlorophenyl)-N′-[3-[6-(1-pyrrolidinyl)-2-pyridinyl]phenyl]-urea;Urea, N-(4-chlorophenyl)-N'-[3-[6-(1-pyrrolidinyl)-2-pyridinyl]phenyl]-
CBNumber
CB92651302
Molecular Formula
C22H21ClN4O
Formula Weight
392.88
MOL File
877202-74-9.mol
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1-(4-Chlorophenyl)-3-[3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl]urea Property

Boiling point:
521.5±50.0 °C(Predicted)
Density 
1.332
storage temp. 
2-8°C
solubility 
DMSO: soluble15mg/mL (clear solution)
pka
13.45±0.70(Predicted)
form 
powder
color 
white to beige
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36
Safety Statements 
26
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0298
Product name
PSNCBAM-1
Purity
≥98% (HPLC)
Packaging
5mg
Price
$152
Updated
2025/07/31
Sigma-Aldrich
Product number
SML0298
Product name
PSNCBAM-1
Purity
≥98% (HPLC)
Packaging
25mg
Price
$411
Updated
2025/07/31
Cayman Chemical
Product number
25855
Product name
PSNCBAM-1
Packaging
1mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
25855
Product name
PSNCBAM-1
Packaging
25mg
Price
$447
Updated
2024/03/01
Cayman Chemical
Product number
25855
Product name
PSNCBAM-1
Packaging
5mg
Price
$143
Updated
2024/03/01
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1-(4-Chlorophenyl)-3-[3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl]urea Chemical Properties,Usage,Production

Uses

PSNCBAM-1 is a selective CB1 receptor allosteric antagonist with an EC50 of 0.1 μM. PSNCBAM-1 can be used in the researches of obesity[1].

Biological Activity

PSNCBAM-1 is an allosteric, non-competitive antagonist of CB-1. The compound blocks the effects of WIN 55212-2 and CP55940, and reduces food intake and weight gain in rats.

IC 50

hCB1-R: 0.1 μM (EC50)

storage

Store at +4°C

References

[1] Horswill JG, et al. PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats. Br J Pharmacol. 2007 Nov;152(5):805-14. DOI:10.1038/sj.bjp.0707347

1-(4-Chlorophenyl)-3-[3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl]urea Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(4-Chlorophenyl)-3-[3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl]urea Suppliers

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877202-74-9, 1-(4-Chlorophenyl)-3-[3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl]ureaRelated Search:


  • 1-(4-Chlorophenyl)-3-[3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl]urea
  • PSNCBAM 1
  • N-(4-Chlorophenyl)-N′-[3-[6-(1-pyrrolidinyl)-2-pyridinyl]phenyl]-urea
  • Urea, N-(4-chlorophenyl)-N'-[3-[6-(1-pyrrolidinyl)-2-pyridinyl]phenyl]-
  • PSNCBAM-1 >=98% (HPLC)
  • PSNCBAM-1,PSNCBAM1,inhibit,Inhibitor,Cannabinoid Receptor
  • PSNCBAM-1, 10 mM in DMSO
  • 877202-74-9