6-BroMo-1-Methyl-1H-pyrazolo[4,3-b]pyridine

Product Name: 6-BroMo-1-Methyl-1H-pyrazolo[4,3-b]pyridine
CAS No.: 1150617-56-3
Chemical Name: 6-BroMo-1-Methyl-1H-pyrazolo[4,3-b]pyridine
Synonyms: 6-bromo-1-methylpyrazolo[4,3-b]pyridine;6-BroMo-1-Methyl-1H-pyrazolo[4,3-b]pyridine;1H-Pyrazolo[4,3-b]pyridine, 6-bromo-1-methyl-
CBNumber: CB92651458
Molecular Formula: C7H6BrN3
Formula Weight: 212.05
MOL File: 1150617-56-3.mol

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6-BroMo-1-Methyl-1H-pyrazolo[4,3-b]pyridine Property

Boiling point:: 287.0±20.0 °C(Predicted)
Density: 1.76±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 2.19±0.30(Predicted)
Appearance: White to light yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B808473
Product name: 6-Bromo-1-methyl-1H-pyrazolo[4,3-b]pyridine
Packaging: 10g
Price: $75
Updated: 2021/12/16

TRC

Product number: B808473
Product name: 6-Bromo-1-methyl-1H-pyrazolo[4,3-b]pyridine
Packaging: 5g
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 124279
Product name: 6-Bromo-1-methyl-1H-pyrazolo[4,3-b]pyridine
Purity: 95+%
Packaging: 1g
Price: $1007
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-9-E5
Product name: 6-Bromo-1-methyl-1H-pyrazolo[4,3-b]pyridine
Purity: 97.0%
Packaging: 1g
Price: $1290
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-9-E5
Product name: 6-Bromo-1-methyl-1H-pyrazolo[4,3-b]pyridine
Purity: 97.0%
Packaging: 5G
Price: $2020
Updated: 2021/12/16

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6-BroMo-1-Methyl-1H-pyrazolo[4,3-b]pyridine Chemical Properties,Usage,Production

Uses

6-bromo-1-methyl-1H-pyrazolo[4,3-b]pyridine can be useful in the preparation, SAR and biological evaluation of (pyrimidinyl)-pyrazolo[4,3-b]pyridine derivatives as dual FLT3/CDK4 inhibitors.

Synthesis

1150617-54-1

74-88-4

1150617-56-3

To a solution of 6-bromo-1H-pyrazolo[4,3-b]pyridine (400 mg, 2.02 mmol) in N,N-dimethylformamide (DMF, 10 mL) was slowly added a mineral oil dispersion of 60% sodium hydride (NaH) (80.8 mg, 2.02 mmol) at 0 °C. The reaction mixture was stirred at room temperature for 30 min. Subsequently, a solution of iodomethane (MeI, 287 mg, 2.02 mmol) in DMF (5 mL) was added dropwise and stirring was continued for 30 minutes at room temperature. Upon completion of the reaction, the mixture was poured into water and extracted with ethyl acetate (EtOAc). The organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. Purification of the residue by preparative reversed-phase high performance liquid chromatography (HPLC) afforded the target compound 6-bromo-1-methyl-1H-pyrazolo[4,3-b]pyridine as a white solid (150 mg, 35% yield).1H NMR (300 MHz, DMSO-d6) δ 8.58-8.60 (m, 2H), 8.30-8.31 (m, 1H) 4.06 (s, 3H).

References

[1] Patent: WO2015/31613, 2015, A1. Location in patent: Paragraph 000176
[2] Patent: US2013/281433, 2013, A1. Location in patent: Paragraph 0854
[3] Patent: WO2016/57834, 2016, A1. Location in patent: Paragraph 000574

6-BroMo-1-Methyl-1H-pyrazolo[4,3-b]pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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6-BroMo-1-Methyl-1H-pyrazolo[4,3-b]pyridine Suppliers

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