ChemicalBook > CAS DataBase List > TD-198946

TD-198946

Product Name: TD-198946
CAS No.: 364762-86-7
Chemical Name: TD-198946
Synonyms: TD-198946;TD-198946, >98%;TD198946;TD 198946;TD-198946, 10 mM in DMSO;TD-198946,inhibit,Inhibitor;1-(3-PYRIDINYLMETHYL)-4-PIPERIDINOL DIHYDROCHLORIDE;1H-THIENO[3,4-G]INDAZOLE-6-CARBOXAMIDE, 4,5-DIHYDRO-1-METHYL-8-[4-(2-QUIN+;1-methyl-8-{4-[(quinolin-2-yl)methoxy]phenoxy}-1H,4H,5H-thieno[3,4-g]indazole-6-carboxamide;4,5-dihydro-1-methyl-8-[4-(2-quinolinylmethoxy)phenoxy]-1H-thieno[3,4-g]indazole-6-carboxamide;1-Methyl-8-(4-(quinolin-2-ylmethoxy)phenoxy)-4,5-dihydro-1H-thieno[3,4-g]indazole-6-carboxamide
CBNumber: CB92655421
Molecular Formula: C27H22N4O3S
Formula Weight: 482.55
MOL File: 364762-86-7.mol

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TD-198946 Property

Boiling point:: 699.5±55.0 °C(Predicted)
Density: 1.43±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 15.87±0.20(Predicted)
form: Solid
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

CSNpharm

Product number: CSN27600
Product name: TD-198946
Packaging: 1mg
Price: $100
Updated: 2021/12/16

Ambeed

Product number: A708965
Product name: Td-198946
Purity: 98%
Packaging: 5mg
Price: $211
Updated: 2021/12/16

CSNpharm

Product number: CSN27600
Product name: TD-198946
Packaging: 5mg
Price: $300
Updated: 2021/12/16

CSNpharm

Product number: CSN27600
Product name: TD-198946
Packaging: 10g
Price: $460
Updated: 2021/12/16

DC Chemicals

Product number: DC10118
Product name: TD-198946
Purity: >98%
Packaging: 100mg
Price: $800
Updated: 2021/12/16

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TD-198946 Chemical Properties,Usage,Production

Uses

TD-198946, a thienoindazole derivative, is a potent chondrogenic agent.

Biological Activity

TD-198946 is a thienoazole derivative,it is a highly potent cartilage-forming agent.

in vitro

TD-198946 is a potent chondrogenic agent. TD-198946 strongly induces chondrogenic differentiation without promoting hypertrophy in cell and metatarsal organ cultures. TD-198946 induces stronger Col2a1 promoter activity than insulin in ATDC5 cells. In C3H10T1/2 cells, ATDC5 cells and primary mouse chondrocytes, TD-198946 dose-dependently stimulates endogenous expression of the chondrocyte markers Col2a1 and Acan , with maximum effects around 1-10 μM.

in vivo

When administered directly into the joint space, TD-198946 successfully prevents and repaires degeneration of the articular cartilage.It exerts its effect through the regulation of Runx1 expression, which is downregulated in both mouse and human OA cartilage compared with normal tissue.It has disease-modifying effects on progressed osteoarthritis.It may prevent the progression of osteoarthritis by acting on the remaining chondrocytes rather than repairing damaged cartilage, it may be most effective as a therapeutic during the early or middle stages of osteoarthritis, before the articular cartilage is fully eroded. Cartilaginous cell-sheets are generated by culturing mouse and canine costal chondrocytes and human mesenchymal stem cells with TD-198946 on temperature-responsive dishes.

References

[1] Yano F, et al. A novel disease-modifying osteoarthritis drug candidate targeting Runx1. Ann Rheum Dis. 2013 May;72(5):748-53. DOI:10.1136/annrheumdis-2012-201745
[2] Yano F, et al. Disease-modifying effects of TD-198946 on progressed osteoarthritis in a mouse model. Ann Rheum Dis. 2014 Nov;73(11):2062-4. DOI:10.1136/annrheumdis-2014-205672
[3] Yano F, et al. Cell-sheet technology combined with a thienoindazole derivative small compound TD-198946 for cartilage regeneration. Biomaterials. 2013 Jul;34(22):5581-7. DOI:10.1016/j.biomaterials.2013.04.008
[4] Kobayashi M, Chijimatsu R, Hart DA, et al. Evidence that TD-198946 enhances the chondrogenic potential of human synovium-derived stem cells through the NOTCH3 signaling pathway. J Tissue Eng Regen Med. 2021;15(2):103-115. DOI:10.1002/term.3149

TD-198946 Preparation Products And Raw materials

Raw materials

Preparation Products

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TD-198946 Suppliers

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364762-86-7, TD-198946Related Search:

TD-198946

1-(3-PYRIDINYLMETHYL)-4-PIPERIDINOL DIHYDROCHLORIDE

1-Methyl-8-[4-(2-quinolinylmethoxy)phenoxy]-4,5-dihydro-1H-thieno [3,4-g]indazole-6-carboxamide

4,5-dihydro-1-methyl-8-[4-(2-quinolinylmethoxy)phenoxy]-1H-thieno[3,4-g]indazole-6-carboxamide

TD198946;TD 198946

TD-198946, >98%

TD-198946 (1-methyl-8-[4-(2-quinolinylmethoxy)phenoxy]-4,5-dihydro-1h-thieno [3,4-g]indazole-6-carboxamide)

1H-Thieno[3,4-g]indazole-6-carboxamide, 4,5-dihydro-1-methyl-8-[4-(2-quinolinylmethoxy)phenoxy]-

TD-198946,inhibit,Inhibitor

1-Methyl-8-(4-(quinolin-2-ylmethoxy)phenoxy)-4,5-dihydro-1H-thieno[3,4-g]indazole-6-carboxamide

1H-THIENO[3,4-G]INDAZOLE-6-CARBOXAMIDE, 4,5-DIHYDRO-1-METHYL-8-[4-(2-QUIN+

1-methyl-8-{4-[(quinolin-2-yl)methoxy]phenoxy}-1H,4H,5H-thieno[3,4-g]indazole-6-carboxamide

TD-198946, 10 mM in DMSO

364762-86-7