ChemicalBook > CAS DataBase List > 2-HYDROXY-5-(TRIFLUOROMETHOXY)BENZALDEHYDE

2-HYDROXY-5-(TRIFLUOROMETHOXY)BENZALDEHYDE

Product Name: 2-HYDROXY-5-(TRIFLUOROMETHOXY)BENZALDEHYDE
CAS No.: 93249-62-8
Chemical Name: 2-HYDROXY-5-(TRIFLUOROMETHOXY)BENZALDEHYDE
Synonyms: BUTTPARK 22\04-61;5-(Trifloromethoxy)salicylaldehyde;5-(TRIFLUOROMETHOXY)SALICYLALDEHYDE;2-HYDROXY-5-(TRIFLUOROMETHOXY)BENZALDEHY;5-(TrifluoroMethoxy)salicylaldehyde, 98+%;2-HYDROXY-5-(TRIFLUOROMETHOXY)BENZALDEHYDE;20HYDROXY-5-(TRIFLUOROMETHOXY)BENZALDEHYDE;Benzaldehyde, 2-hydroxy-5-(trifluoromethoxy)-;2-Hydroxy-5-(trifluoromethoxy)benzaldehyde99%;2-Hydroxy-5-(trifluoromethoxy)benzaldehyde 99%
CBNumber: CB9265660
Molecular Formula: C8H5F3O3
Formula Weight: 206.12
MOL File: 93249-62-8.mol

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2-HYDROXY-5-(TRIFLUOROMETHOXY)BENZALDEHYDE Property

Melting point:: 31-33 °C (lit.)
Boiling point:: 82 °C/60 mmHg (lit.)
Density: 1.4251 (estimate)
Flash point:: >230 °F
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 7.56±0.18(Predicted)
form: Low Melting Solid
color: White to pale yellow
Sensitive: Air Sensitive
BRN: 7023825
CAS DataBase Reference: 93249-62-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29130000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: H977605
Product name: 2-Hydroxy-5-(trifluoromethoxy)benzaldehyde
Packaging: 10mg
Price: $45
Updated: 2021/12/16

TRC

Product number: H977605
Product name: 2-Hydroxy-5-(trifluoromethoxy)benzaldehyde
Packaging: 50mg
Price: $60
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2615-3-15
Product name: 5-(Trifluoromethoxy)salicylaldehyde
Purity: 99%
Packaging: 5G
Price: $68
Updated: 2021/12/16

AK Scientific

Product number: 5778AC
Product name: 2-Hydroxy-5-(trifluoromethoxy)benzaldehyde
Packaging: 1g
Price: $77
Updated: 2021/12/16

Matrix Scientific

Product number: 005369
Product name: 5-(Trifluoromethoxy)salicylaldehyde
Purity: 95+%
Packaging: 1g
Price: $21
Updated: 2021/12/16

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2-HYDROXY-5-(TRIFLUOROMETHOXY)BENZALDEHYDE Chemical Properties,Usage,Production

Chemical Properties

White to pale yellow low melting solid

Uses

2-Hydroxy-5-(trifluoromethoxy)benzaldehyde may be used in the preparation of :

2-[(E)-2-hydroxy-5-(trifluoromethoxy)benzylideneamino]-4-methylphenol
(E)-2-((3-fluorophenylimino)methyl)-4-(trifluoromethoxy) phenol
2-[(E)-(naphthalen-2-ylimino) methyl]-4-(trifluoromethoxy) phenol

General Description

2-Hydroxy-5-(trifluoromethoxy)benzaldehyde is formed as intermediate during the biotransformation pathways of CP-122,721 in humans.

Synthesis

145742-65-0

93249-62-8

Step A: Boron tribromide (BBr3, 85.2 g, 341 mmol) was slowly added dropwise to a solution of 2-methoxy-5-(trifluoromethoxy)benzaldehyde (50.0 g, 227 mmol) in dichloromethane (DCM, 500 mL) at -20°C and under nitrogen protection. The reaction mixture was stirred at 0°C for 2 hours. Upon completion of the reaction, the reaction was quenched by the addition of ice chips, followed by pouring the mixture into an aqueous solution of saturated sodium bicarbonate (NaHCO3, 300 mL) and extracting with dichloromethane (DCM, 3 x 400 mL). The organic layers were combined, dried over anhydrous sodium sulfate and concentrated to give the crude product. The crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=20:1) to afford 2-hydroxy-5-(trifluoromethoxy)benzaldehyde (38.0 g, 81.0% yield). NMR hydrogen spectrum (400 MHz, CDCl3) δ 10.97 (s, 1H), 9.87 (s, 1H), 7.43-7.38 (m, 2H), 7.02 (d, J=8.0 Hz, 1H).

References

[1] Patent: WO2013/148851, 2013, A1. Location in patent: Paragraph 00244
[2] Patent: US2014/275172, 2014, A1. Location in patent: Paragraph 0842

2-HYDROXY-5-(TRIFLUOROMETHOXY)BENZALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-HYDROXY-5-(TRIFLUOROMETHOXY)BENZALDEHYDE Suppliers

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View Lastest Price from 2-HYDROXY-5-(TRIFLUOROMETHOXY)BENZALDEHYDE manufacturers

Career Henan Chemical Co

Product: 2-HYDROXY-5-(TRIFLUOROMETHOXY)BENZALDEHYDE 93249-62-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg,5kg,100kg
Release date: 2019-07-04

93249-62-8, 2-HYDROXY-5-(TRIFLUOROMETHOXY)BENZALDEHYDERelated Search:

BUTTPARK 22\04-61

5-(TRIFLUOROMETHOXY)SALICYLALDEHYDE

2-HYDROXY-5-(TRIFLUOROMETHOXY)BENZALDEHYDE

5-(Trifloromethoxy)salicylaldehyde

20HYDROXY-5-(TRIFLUOROMETHOXY)BENZALDEHYDE

2-Hydroxy-5-(trifluoromethoxy)benzaldehyde 99%

2-Hydroxy-5-(trifluoromethoxy)benzaldehyde99%

2-Hydroxy-5-(trifluoromethoxy)benzaldehyde, 98+%

5-(Trifluoromethoxy)salicylaldehyde, 2-Formyl-4-(trifluoromethoxy)phenol

5-(TrifluoroMethoxy)salicylaldehyde, 98+%

Benzaldehyde, 2-hydroxy-5-(trifluoromethoxy)-

2-HYDROXY-5-(TRIFLUOROMETHOXY)BENZALDEHY

93249-62-8

CF3OC6H3OHCHO

Aldehydes

Building Blocks

Carbonyl Compounds

Organic Building Blocks

Aromatic Aldehydes & Derivatives (substituted)