6-Chloro-5-fluoro-2-MethylpyriMidin-4-aMine
- Product Name
- 6-Chloro-5-fluoro-2-MethylpyriMidin-4-aMine
- CAS No.
- 943006-45-9
- Chemical Name
- 6-Chloro-5-fluoro-2-MethylpyriMidin-4-aMine
- Synonyms
- 6-chloro-5-fluoro-2-methyl-4-Pyrimidinamine;6-Chloro-5-fluoro-2-MethylpyriMidin-4-aMine;4-Pyrimidinamine, 6-chloro-5-fluoro-2-methyl-
- CBNumber
- CB92656998
- Molecular Formula
- C5H5ClFN3
- Formula Weight
- 161.56
- MOL File
- 943006-45-9.mol
6-Chloro-5-fluoro-2-MethylpyriMidin-4-aMine Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933599590
N-Bromosuccinimide Price
- Product number
- PC408560
- Product name
- 6-Chloro-5-fluoro-2-methylpyrimidin-4-amine
- Packaging
- 250mg
- Price
- $134
- Updated
- 2021/12/16
- Product number
- 3H30-7-90
- Product name
- 6-Chloro-5-fluoro-2-methylpyrimidin-4-amine
- Packaging
- 250mg
- Price
- $215
- Updated
- 2021/12/16
- Product number
- PC408560
- Product name
- 6-Chloro-5-fluoro-2-methylpyrimidin-4-amine
- Packaging
- 1g
- Price
- $334
- Updated
- 2021/12/16
- Product number
- HCH0367973
- Product name
- 6-CHLORO-5-FLUORO-2-METHYLPYRIMIDIN-4-AMINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.89
- Updated
- 2021/12/16
- Product number
- 3H30-7-90
- Product name
- 6-Chloro-5-fluoro-2-methylpyrimidin-4-amine
- Packaging
- 1g
- Price
- $535
- Updated
- 2021/12/16
6-Chloro-5-fluoro-2-MethylpyriMidin-4-aMine Chemical Properties,Usage,Production
Synthesis
105806-13-1
943006-45-9
Part C: 4,6-Dichloro-5-fluoro-2-methylpyrimidine (1.55 g, 8.56 mmol), ammonium hydroxide solution (35%, 10.0 mL, 257 mmol) and methanol (1.00 mL) were mixed in a sealed tube and the reaction was heated for 2 hours at 70 °C. After completion of the reaction, the mixture was cooled to room temperature and precipitate was precipitated. The reaction mixture was diluted by adding water (about 10 mL) and stirring was continued for 30 minutes. The solid product was collected by diafiltration, washed with water and dried in air to afford 4-amino-6-chloro-5-fluoro-2-methylpyrimidine (845 mg, 61% yield) as a brown solid.LC-MS (m/z): 162,164 ([M+H]+).
References
[1] Journal of Medicinal Chemistry, 2012, vol. 55, # 11, p. 5188 - 5219
[2] Patent: WO2007/75852, 2007, A2. Location in patent: Page/Page column 32
[3] Patent: US2007/197523, 2007, A1. Location in patent: Page/Page column 7-8
6-Chloro-5-fluoro-2-MethylpyriMidin-4-aMine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Chloro-5-fluoro-2-MethylpyriMidin-4-aMine manufacturers
- Product
- 6-Chloro-5-fluoro-2-MethylpyriMidin-4-aMine 943006-45-9
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 95%min
- Supply Ability
- 20kg/month
- Release date
- 2019-12-20