ChemicalBook > CAS DataBase List > RRX-001

RRX-001

Product Name: RRX-001
CAS No.: 925206-65-1
Chemical Name: RRX-001
Synonyms: ABDNAZ;RRX-001;[14C]-Rrx-001;RRX 001;RRX001;RRx-001 ，S8405;RRx-001 (ABDNAZ);RRX-001, 10 mM in DMSO;2-Bromo-1-(3,3-dinitro-1-azetidinyl)ethanone;2-Bromo-1-(3,3-dinitroazetidin-1-yl)ethanone;2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one
CBNumber: CB92658200
Molecular Formula: C5H6BrN3O5
Formula Weight: 268.02
MOL File: 925206-65-1.mol

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RRX-001 Property

Boiling point:: 473.0±45.0 °C(Predicted)
Density: 1.98±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 2 mg/ml
form: A solid
pka: -2.07±0.20(Predicted)
color: White to off-white
InChI: InChI=1S/C5H6BrN3O5/c6-1-4(10)7-2-5(3-7,8(11)12)9(13)14/h1-3H2
InChIKey: JODKFOVZURLVTG-UHFFFAOYSA-N
SMILES: C(=O)(N1CC([N+]([O-])=O)([N+]([O-])=O)C1)CBr

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H331Toxic if inhaled

H341Suspected of causing genetic defects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P310Immediately call a POISON CENTER or doctor/physician.

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28846
Product name: RRx-001
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 28846
Product name: RRx-001
Packaging: 25mg
Price: $586
Updated: 2024/03/01

Cayman Chemical

Product number: 28846
Product name: RRx-001
Packaging: 5mg
Price: $172
Updated: 2024/03/01

Cayman Chemical

Product number: 28846
Product name: RRx-001
Packaging: 10mg
Price: $321
Updated: 2024/03/01

ChemScene

Product number: CS-5286
Product name: RRx-001
Purity: 99.71%
Packaging: 5mg
Price: $144
Updated: 2021/12/16

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RRX-001 Chemical Properties,Usage,Production

Uses

RRx-001, a hypoxia-selective epigenetic agent and studied as a radio- and chem-sensitizer, triggers apoptosis and overcomes agent resistance in myeloma. RRx-001 exhibits potent anti-tumor activity with minimal toxicity[1]. RRx-001 is a dual small molecule checkpoint inhibitor by downregulating CD47 and SIRP-α[2]. RRx-001 is a potent inhibitor of G6PD and shows potent antimalarial activity[3].

Biological Activity

RRx-001 is a novel epigenetic modulator with potential radiosensitizing activity. In human tumor cells, it inhibits glucose 6-phosphate dehydrogenase (G6PD), binds to hemoglobin and drives RBC-mediated redox reactions under hypoxia.It can trigger apoptosis and has antitumor activity.

in vitro

RRx-001 exerts its antiproliferative effect by interfering with glucose 6 phosphate dehydrogenase (G6PD), a key enzyme in the pentose phosphate pathway. RRx-001 induces p53 and PARP-1 through ROS/RNS generation. It exerts its anticancer activity by interfering and disrupting 3 crucial metabolic demands in rapidly proliferating cells: bioenergetics, macromolecular biosynthesis and manipulation of cellular cytoplasmic redox homeostasis.RRx-001 also mediates the nuclear translocation of Nrf2 and the expression of its downstream HO-1 and NQO1 in tumor cells.

in vivo

RRx-001 has a short-term blood flow redistribution effect in tumors enriched in pericytes and α-SMA vessels.It was well tolerated without dose-limiting toxic side effects. In mice, it not only promoted nuclear transport of Nrf2, but also upregulated the expression of endogenous Nrf2 in SCC VII tumors.

target

Target	Value
G6PD ()
Nrf2-ARE

IC 50

Plasmodium

References

[1] Das DS, et al. A novel hypoxia-selective epigenetic agent RRx-001 triggers apoptosis and overcomes drug resistance in multiple myeloma cells. Leukemia. 2016 Nov;30(11):2187-2197. DOI:10.1038/leu.2016.96
[2] Yalcin O, et al. From METS to malaria: RRx-001, a multi-faceted anticancer agent with activity in cerebral malaria. Malar J. 2015 May 28;14:218. DOI:10.1186/s12936-015-0720-5
[3] Cabrales P, et al. RRx-001 Acts as a Dual Small Molecule Checkpoint Inhibitor by Downregulating CD47 on Cancer Cells and SIRP-α on Monocytes/Macrophages. Transl Oncol. 2019 Apr;12(4):626-632. DOI:10.1016/j.tranon.2018.12.001

RRX-001 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from RRX-001 manufacturers

Career Henan Chemical Co

Product: RRX-001 925206-65-1
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2020-02-18

925206-65-1, RRX-001Related Search:

RRX-001

2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one

RRX 001;RRX001

[14C]-Rrx-001

2-Bromo-1-(3,3-dinitroazetidin-1-yl)ethanone

Ethanone, 2-bromo-1-(3,3-dinitro-1-azetidinyl)-

RRx-001 (ABDNAZ)

ABDNAZ

Parasite,RRx-001,RRX 001,Apoptosis,Inhibitor,inhibit,RRX001

2-Bromo-1-(3,3-dinitro-1-azetidinyl)ethanone

RRX-001, 10 mM in DMSO

RRx-001 ，S8405

2-bromo-1-(3,3-dinitroazetidin-1-yl)ethanone - [B87929]

925206-65-1

C5H6BrN3O5