(5,6,7,8-Tetrahydronaphthalen-1-yl)Methanol
- Product Name
- (5,6,7,8-Tetrahydronaphthalen-1-yl)Methanol
- CAS No.
- 41790-30-1
- Chemical Name
- (5,6,7,8-Tetrahydronaphthalen-1-yl)Methanol
- Synonyms
- 5,6,7,8-Tetrahydro-1-naphthaleneMethanol;1-NAPHTHALENEMETHANOL, 5,6,7,8-TETRAHYDRO-;(5,6,7,8-Tetrahydronaphthalen-1-yl)Methanol;1-(Hydroxymethyl)-5,6,7,8-tetrahydronaphthalene
- CBNumber
- CB92661264
- Molecular Formula
- C11H14O
- Formula Weight
- 162.23
- MOL File
- 41790-30-1.mol
(5,6,7,8-Tetrahydronaphthalen-1-yl)Methanol Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Off-white to light yellow Oil
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T293995
- Product name
- 5,6,7,8-Tetrahydro-1-naphthalenemethanol
- Packaging
- 250mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- 162008
- Product name
- 5,6,7,8-Tetrahydro-1-naphthalenemethanol
- Packaging
- 250mg
- Price
- $460
- Updated
- 2021/12/16
- Product number
- Z4732
- Product name
- (5,6,7,8-Tetrahydronaphthalen-1-yl)methanol
- Packaging
- 250mg
- Price
- $132
- Updated
- 2021/12/16
- Product number
- CHM0390517
- Product name
- (5,6,7,8-TETRAHYDRONAPHTHALEN-1-YL)METHANOL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.5
- Updated
- 2021/12/16
- Product number
- 61998
- Product name
- 5,6,7,8-Tetrahydro-1-naphthalenemethanol
- Packaging
- 250mg
- Price
- $650
- Updated
- 2021/12/16
(5,6,7,8-Tetrahydronaphthalen-1-yl)Methanol Chemical Properties,Usage,Production
Uses
5,6,7,8-Tetrahydro-1-naphthalenemethanol, is used as an intermediate in various chemical synthesis. It is utilized in the preparation of tricyclic benzazepines, having dopamine D1- and D2-affinity.
Synthesis
4242-18-6
41790-30-1
General procedure for the synthesis of 1-(hydroxymethyl)-5,6,7,8-tetrahydronaphthalene from 5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid: 5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid (2.0 g, 11 mmol) was dissolved in tetrahydrofuran (THF, 30 mL), and the borane-THF solution was slowly added at 0°C (23 mL, 0.98 M THF solution. 23 mmol). The reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, the reaction was quenched by careful addition of water at 0 °C, followed by extraction with ethyl acetate. The organic layer was washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography with gradient elution from hexane to hexane/ethyl acetate (3:1, v/v) as eluent to give 1-(hydroxymethyl)-5,6,7,8-tetrahydronaphthalene (1.9 g, colorless oil, quantitative yield).
References
[1] Patent: JP2016/222570, 2016, A. Location in patent: Paragraph 0034
[2] Patent: WO2017/155909, 2017, A1. Location in patent: Paragraph 0099
[3] Patent: US5610177, 1997, A
[4] Tetrahedron, 1997, vol. 53, # 47, p. 15969 - 15982
[5] Patent: WO2017/156181, 2017, A1. Location in patent: Paragraph 00349
(5,6,7,8-Tetrahydronaphthalen-1-yl)Methanol Preparation Products And Raw materials
Raw materials
Preparation Products
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