ChemicalBook > CAS DataBase List > A 438079 (hydrochloride)

A 438079 (hydrochloride)

Product Name
A 438079 (hydrochloride)
CAS No.
899431-18-6
Chemical Name
A 438079 (hydrochloride)
Synonyms
A-438079 HCl;A-438079 HCl ，S7705;A-438079;A438079;A 438079;A 438079 hydrochloride, 10 mM in DMSO;A 438079, competitive P2X7 receptor antagonist;3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine monohydrochloride;P2X Receptor,A-438079,P2XRs,A 438079 hydrochloride,A438079,Inhibitor,inhibit,A 438079
CBNumber
CB92666582
Molecular Formula
C13H10Cl3N5
Formula Weight
342.611
MOL File
899431-18-6.mol
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A 438079 (hydrochloride) Property

storage temp. 
-20°C
solubility 
Soluble in DMSO (>25 mg/ml)
form 
solid
color 
White to off-white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A9736
Product name
A-438079 hydrochloride hydrate
Purity
≥98% (HPLC)
Packaging
5 mg
Price
$145.35
Updated
2025/07/31
Sigma-Aldrich
Product number
A9736
Product name
A-438079 hydrochloride hydrate
Purity
≥98% (HPLC)
Packaging
25 mg
Price
$580.45
Updated
2025/07/31
Cayman Chemical
Product number
14580
Product name
A-438079 (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$168
Updated
2024/03/01
Cayman Chemical
Product number
14580
Product name
A-438079 (hydrochloride)
Purity
≥98%
Packaging
50mg
Price
$570
Updated
2024/03/01
Cayman Chemical
Product number
14580
Product name
A-438079 (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$89
Updated
2024/03/01
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A 438079 (hydrochloride) Chemical Properties,Usage,Production

Description

A-438079 is a competitive antagonist of the nucleotide receptor P2X7 (pIC50 = 6.9). It inhibits both calcium flux and IL-1β release mediated by P2X7 while not affecting the activity of other P2X receptors. A-438079 is effective in evaluating the role of P2X7 in nociception, oxidative stress, and apoptosis in cells and animals.

Uses

3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine is a 1-Benzyl-5-aryltetrazole derivative and potential antagonists for the P2X7 receptor.

in vitro

In 1321N1 cells stably expressing rat P2X 7 receptors, A 438079 blocks BzATP-(10 μM) evoked changes in intracellular calcium concentrations with an IC 50 of 321 nM. A 438079 is also selective for the P2X 7 receptor, at concentrations up to 100 μM.

in vivo

A 438079 (80 μmol/kg, i.v.) reduces noxious and innocuous evoked activity of different classes of spinal neurons in neuropathic rats. A 438079 (100 and 300 μmol/kg, i.p.) signi?cantly raises withdrawal thresh-olds in both the SNL and CCI models. Intraperitoneal injection of A 438079 (5 and 15 mg/kg) 60 min after triggering seizures reduces seizure severity and neuronal death within the hippocampus. A 438079 has superior neuroprotective effects compared with an equally dose of phenobarbital (25 mg/kg). A 438079 partially but signi?cantly prevents the 6-OHDA-induced depletion of striatal DA stores. Pretreatment with A 438079 reduces nociceptive behaviour scores in the HC model.

IC 50

P2X7 Receptor

storage

Desiccate at RT

References

[1] DEREK W. NELSON. Structure−Activity Relationship Studies on a Series of Novel, Substituted 1-Benzyl-5-phenyltetrazole P2X7 Antagonists[J]. Journal of Medicinal Chemistry, 2006, 49 12: 3659-3666. DOI:10.1021/jm051202e
[2] S. MCGARAUGHTY. P2X7-related modulation of pathological nociception in rats[J]. Neuroscience, 2007, 146 4: Pages 1817-1828. DOI:10.1016/j.neuroscience.2007.03.035
[3] ANNA K CLARK. P2X7-dependent release of interleukin-1beta and nociception in the spinal cord following lipopolysaccharide.[J]. Journal of Neuroscience, 2010, 30 2: 573-582. DOI:10.1523/jneurosci.3295-09.2010
[4] KIMIKO KOBAYASHI . Induction of the P2X7 receptor in spinal microglia in a neuropathic pain model[J]. Neuroscience Letters, 2011, 504 1: Pages 57-61. DOI:10.1016/j.neulet.2011.08.058
[5] KETAN CHU. Inhibition of P2X7 receptor ameliorates transient global cerebral ischemia/reperfusion injury via modulating inflammatory responses in the rat hippocampus.[J]. Journal of Neuroinflammation, 2012: 69. DOI:10.1186/1742-2094-9-69

A 438079 (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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A 438079 (hydrochloride) Suppliers

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View Lastest Price from A 438079 (hydrochloride) manufacturers

Career Henan Chemica Co
Product
A 438079 (hydrochloride) 899431-18-6
Price
US $0.01/KG
Min. Order
1KG
Purity
95%-99%
Supply Ability
1kg; 5kg; 10kg
Release date
2020-10-28

899431-18-6, A 438079 (hydrochloride)Related Search:

Fruquintinib DO264 Pomalidomide Ibrutinib

  • 3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine monohydrochloride
  • A-438079 HCl
  • A-438079;A438079;A 438079
  • P2X Receptor,A-438079,P2XRs,A 438079 hydrochloride,A438079,Inhibitor,inhibit,A 438079
  • A 438079, competitive P2X7 receptor antagonist
  • A 438079 hydrochloride, 10 mM in DMSO
  • A-438079 HCl ，S7705
  • 899431-18-6
  • Inhibitors