(S)-2-(1-((2-aMino-9H-purin-6-yl)aMino)ethyl)-5-Methyl-3-(o-tolyl)quinazolin-4(3H)-one hydrochloride

Product Name: (S)-2-(1-((2-aMino-9H-purin-6-yl)aMino)ethyl)-5-Methyl-3-(o-tolyl)quinazolin-4(3H)-one hydrochloride
CAS No.: 1431697-78-7
Chemical Name: (S)-2-(1-((2-aMino-9H-purin-6-yl)aMino)ethyl)-5-Methyl-3-(o-tolyl)quinazolin-4(3H)-one hydrochloride
Synonyms: CAL-130 HCl;CAL-130 (Hydrochloride);CAL130 Hydrochloride,CAL 130 Hydrochloride;(S)-2-(1-((2-aMino-9H-purin-6-yl)aMino)ethyl)-5-Methyl-3-(o-tolyl)quinazolin-4(3H)-one hydrochloride;2-[(1S)-1-[(2-Amino-9H-purin-6-yl)amino]ethyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone hydrochloride (1:1)
CBNumber: CB92666603
Molecular Formula: C23H23ClN8O
Formula Weight: 462.94
MOL File: 1431697-78-7.mol

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(S)-2-(1-((2-aMino-9H-purin-6-yl)aMino)ethyl)-5-Methyl-3-(o-tolyl)quinazolin-4(3H)-one hydrochloride Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FC64968
Product name: CAL 130 hydrochloride
Packaging: 10mg
Price: $175
Updated: 2021/12/16

ChemScene

Product number: CS-1300
Product name: CAL-130Hydrochloride
Purity: 99.88%
Packaging: 5mg
Price: $264
Updated: 2021/12/16

ApexBio Technology

Product number: A3268
Product name: CAL-130Hydrochloride
Packaging: 2mg
Price: $279
Updated: 2021/12/16

ChemScene

Product number: CS-1300
Product name: CAL-130Hydrochloride
Purity: 99.88%
Packaging: 10mg
Price: $360
Updated: 2021/12/16

ApexBio Technology

Product number: A3268
Product name: CAL-130Hydrochloride
Packaging: 5mg
Price: $419
Updated: 2021/12/16

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(S)-2-(1-((2-aMino-9H-purin-6-yl)aMino)ethyl)-5-Methyl-3-(o-tolyl)quinazolin-4(3H)-one hydrochloride Chemical Properties,Usage,Production

Biological Activity

CAL-130 Hydrochloride is a PI3Kδ and PI3Kγ inhibitor with IC50 of 1.3 and 6.1 nM, respectively.

in vitro

CAL-130 preferentially inhibits the function of both p110γ and p110δ catalytic domains. IC ₅₀ values of CAL-130 are 1.3 and 6.1 nM for p110δ and p110γ, respectively, as compared to 115 and 56 nM for p110α and p110β. CAL-130 does not inhibit additional intracellular signaling pathways (ie, p38 MAPK or insulin receptor tyrosine kinase) that are critical for general cell function and survival.

in vivo

The clinical significance of interfering with the combined activities of PI3Kγ and PI3Kδ is determined by administering CAL-130 to Lck/Pten ^fl/fl mice with established T cell acute lymphoblastic leukemia (T-ALL). Candidate animals for survival studies are ill appearing, have a white blood cell (WBC) count above 45,000 μL ^-1 , evidence of blasts on peripheral smear, and a majority of circulation cells (>75%) staining double positive for Thy1.2 and Ki-67. Mice receive an oral dose (10 mg/kg) of CAL-130 every 8 hr for a period of 7 days and are then followed until moribund. Despite the limited duration of therapy, CAL-130 is highly effective in extending the median survival for treated animals to 45 days as compared 7.5 days for the control group.

target

PI3K

(S)-2-(1-((2-aMino-9H-purin-6-yl)aMino)ethyl)-5-Methyl-3-(o-tolyl)quinazolin-4(3H)-one hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-2-(1-((2-aMino-9H-purin-6-yl)aMino)ethyl)-5-Methyl-3-(o-tolyl)quinazolin-4(3H)-one hydrochloride Suppliers

China 22 United States 10 Global 32

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1431697-78-7, (S)-2-(1-((2-aMino-9H-purin-6-yl)aMino)ethyl)-5-Methyl-3-(o-tolyl)quinazolin-4(3H)-one hydrochlorideRelated Search:

Aspartate aminotransferase

(S)-2-(1-((2-aMino-9H-purin-6-yl)aMino)ethyl)-5-Methyl-3-(o-tolyl)quinazolin-4(3H)-one hydrochloride

CAL-130 (Hydrochloride)

2-[(1S)-1-[(2-Amino-9H-purin-6-yl)amino]ethyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone hydrochloride (1:1)

CAL-130 HCl

CAL130 Hydrochloride,CAL 130 Hydrochloride

1431697-78-7

C23H23ClN8O

C23H22N8OHCl