ChemicalBook > CAS DataBase List > (S)-2-(1-((2-aMino-9H-purin-6-yl)aMino)ethyl)-5-Methyl-3-(o-tolyl)quinazolin-4(3H)-one hydrochloride

(S)-2-(1-((2-aMino-9H-purin-6-yl)aMino)ethyl)-5-Methyl-3-(o-tolyl)quinazolin-4(3H)-one hydrochloride

Product Name
(S)-2-(1-((2-aMino-9H-purin-6-yl)aMino)ethyl)-5-Methyl-3-(o-tolyl)quinazolin-4(3H)-one hydrochloride
CAS No.
1431697-78-7
Chemical Name
(S)-2-(1-((2-aMino-9H-purin-6-yl)aMino)ethyl)-5-Methyl-3-(o-tolyl)quinazolin-4(3H)-one hydrochloride
Synonyms
CAL-130 HCl;CAL-130 (Hydrochloride);CAL130 Hydrochloride,CAL 130 Hydrochloride;(S)-2-(1-((2-aMino-9H-purin-6-yl)aMino)ethyl)-5-Methyl-3-(o-tolyl)quinazolin-4(3H)-one hydrochloride;2-[(1S)-1-[(2-Amino-9H-purin-6-yl)amino]ethyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone hydrochloride (1:1)
CBNumber
CB92666603
Molecular Formula
C23H23ClN8O
Formula Weight
462.94
MOL File
1431697-78-7.mol
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(S)-2-(1-((2-aMino-9H-purin-6-yl)aMino)ethyl)-5-Methyl-3-(o-tolyl)quinazolin-4(3H)-one hydrochloride Property

storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Powder
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FC64968
Product name
CAL 130 hydrochloride
Packaging
10mg
Price
$175
Updated
2021/12/16
ChemScene
Product number
CS-1300
Product name
CAL-130Hydrochloride
Purity
99.88%
Packaging
5mg
Price
$264
Updated
2021/12/16
ApexBio Technology
Product number
A3268
Product name
CAL-130Hydrochloride
Packaging
2mg
Price
$279
Updated
2021/12/16
ChemScene
Product number
CS-1300
Product name
CAL-130Hydrochloride
Purity
99.88%
Packaging
10mg
Price
$360
Updated
2021/12/16
ApexBio Technology
Product number
A3268
Product name
CAL-130Hydrochloride
Packaging
5mg
Price
$419
Updated
2021/12/16
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(S)-2-(1-((2-aMino-9H-purin-6-yl)aMino)ethyl)-5-Methyl-3-(o-tolyl)quinazolin-4(3H)-one hydrochloride Chemical Properties,Usage,Production

Biological Activity

CAL-130 Hydrochloride is a PI3Kδ and PI3Kγ inhibitor with IC50 of 1.3 and 6.1 nM, respectively.

in vitro

CAL-130 preferentially inhibits the function of both p110γ and p110δ catalytic domains. IC 50 values of CAL-130 are 1.3 and 6.1 nM for p110δ and p110γ, respectively, as compared to 115 and 56 nM for p110α and p110β. CAL-130 does not inhibit additional intracellular signaling pathways (ie, p38 MAPK or insulin receptor tyrosine kinase) that are critical for general cell function and survival.

in vivo

The clinical significance of interfering with the combined activities of PI3Kγ and PI3Kδ is determined by administering CAL-130 to Lck/Pten fl/fl mice with established T cell acute lymphoblastic leukemia (T-ALL). Candidate animals for survival studies are ill appearing, have a white blood cell (WBC) count above 45,000 μL -1 , evidence of blasts on peripheral smear, and a majority of circulation cells (>75%) staining double positive for Thy1.2 and Ki-67. Mice receive an oral dose (10 mg/kg) of CAL-130 every 8 hr for a period of 7 days and are then followed until moribund. Despite the limited duration of therapy, CAL-130 is highly effective in extending the median survival for treated animals to 45 days as compared 7.5 days for the control group.

target

PI3K

(S)-2-(1-((2-aMino-9H-purin-6-yl)aMino)ethyl)-5-Methyl-3-(o-tolyl)quinazolin-4(3H)-one hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-2-(1-((2-aMino-9H-purin-6-yl)aMino)ethyl)-5-Methyl-3-(o-tolyl)quinazolin-4(3H)-one hydrochloride Suppliers

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1431697-78-7, (S)-2-(1-((2-aMino-9H-purin-6-yl)aMino)ethyl)-5-Methyl-3-(o-tolyl)quinazolin-4(3H)-one hydrochlorideRelated Search:

Aspartate aminotransferase

  • (S)-2-(1-((2-aMino-9H-purin-6-yl)aMino)ethyl)-5-Methyl-3-(o-tolyl)quinazolin-4(3H)-one hydrochloride
  • CAL-130 (Hydrochloride)
  • 2-[(1S)-1-[(2-Amino-9H-purin-6-yl)amino]ethyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone hydrochloride (1:1)
  • CAL-130 HCl
  • CAL130 Hydrochloride,CAL 130 Hydrochloride
  • 1431697-78-7
  • C23H23ClN8O
  • C23H22N8OHCl