ChemicalBook > CAS DataBase List > MLN-120B

MLN-120B

Product Name: MLN-120B
CAS No.: 783348-36-7
Chemical Name: MLN-120B
Synonyms: ML120B;MLN120B;MLN 120B;MLN-120B;MLN120B ，S7736;MLN120B, 10 mM in DMSO;ML120B; MLN 120B; MLN-120B;MLN120B;ML120B;MLN 120B;MLN-120B;ML 120B dihydrochloride(free base);N-(6-Chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methylnicotinamide
CBNumber: CB92666663
Molecular Formula: C19H15ClN4O2
Formula Weight: 366.8
MOL File: 783348-36-7.mol

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MLN-120B Property

storage temp.: Store at -20°C
solubility: insoluble in H2O; ≥13.2 mg/mL in DMSO; ≥8.53 mg/mL in EtOH with gentle warming and ultrasonic
form: solid
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1174
Product name: ML120B
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $143
Updated: 2025/07/31

TRC

Product number: M425145
Product name: ML120B
Packaging: 25mg
Price: $495
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FM65090
Product name: MLN120B
Packaging: 50mg
Price: $577.5
Updated: 2021/12/16

ApexBio Technology

Product number: A3628
Product name: MLN120B
Packaging: 50mg
Price: $720
Updated: 2021/12/16

AK Scientific

Product number: 3865AH
Product name: MLN120B
Packaging: 50mg
Price: $829
Updated: 2021/12/16

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MLN-120B Chemical Properties,Usage,Production

Uses

ML 120B is a novel competitive inhibitor of ATP and i-kappa-kinase-2 (IKK2), key regulator in the survival, proliferation and apoptosis resistance of lymphoma cells.

Biological Activity

mln120b is a potent and effective inhibitor of iκb kinase beta subunit (ikkβ) with ic50 value of 20 μm [1].ikk is an enzyme complex which is a part of the upstream of nf-κb signal transduction cascade. it is composed of three subunits, including ikkα, ikkβ and ikkγ. the ikkβ subunit is able to phosphorylate iκbα protein. normally, iκbα protein inactivate nf-κb transcription factors and keep them sequestering in inactive state in the cytoplasm. however, once iκbα protein is phosphorylated by ikkβ subunit, the iκbα protein will be dissociated from nf-κb transcription factor and thus remove the inactivation effect. therefore, the transcription of nf-κb will be activated. this signaling pathway is involved in many immune and inflammatory processes.in multiple myeloma cell line rpmi 8226 and ina 6, treatment of mln120b resulted in the dose-dependent inhibition of ikkβ-induced iκbα protein phosphorylation and subsequent nf-κb activation. additionally, it was observed that mln120b was able to block tnf-α-induced nf-κb activation in mm.1s cell line. these observations suggested the inhibitory action of mln120b on ikkβ. [1].in mouse model, polyarthritis was introduced in footpads, where ikkβ-induced nf-κb activation might result in a serial of advert effects. oral administration of mln120b (12 mg/kg twice daily) inhibited paw swelling in a dose-dependent manner, and offered protection against arthritis-induced weight loss. therefore, it could be implied that mln120b was able to inhibit ikkβ-induced nf-κb activation [2].

in vivo

MLN120B (oral administration; 50 mg/kg; twice daily; 3 weeks) induces a reduction of shuIL-6R, marker of tumor growth, marker of tumor growth. It also leads to a rend toward prolonged survival in animals treated versus control^[1].MLN120B (oral administration; 1-30 mg/kg; twice daily; 3 weeks)?inhibits paw swelling in a dose-dependent manner and offers significant protection against arthritis-induced weight loss as well as cartilage and bone erosion. NF-κB activity in arthritic joints is also reduced after MLN120B administration^[2].

Animal Model:	Two-month-old female Lewis rats^[2]
Dosage:	30 mg/kg, 10 mg/kg, 3 mg/kg, or 1 mg/kg
Administration:	Oral administration; twice daily; 3 weeks
Result:	Protected against bone and cartilage destruction in a rat model.

Animal Model:	SCID mice implanted with human fetal bone chips and then INA6 cells are directly injected into mice^[1]
Dosage:	50 mg/kg
Administration:	Oral administration; twice daily; 3 weeks
Result:	Inhibited human multiple myeloma cell growth in vivo.

target

IkappaB beta

IC 50

IKKβ: 60 nM (IC₅₀)

References

[1]. hideshima t, neri p, tassone p. mln120b, a novel ikappab kinase beta inhibitor, blocks multiple myeloma cell growth in vitro and in vivo. clin cancer res. 2006, 12(19): 5887-5894.
[2]. schopf l, savinainen a, anderson k. ikkbeta inhibition protects against bone and cartilage destruction in a rat model of rheumatoid arthritis. arthritis rheum. 2006, 54(10): 3163-3173.

MLN-120B Preparation Products And Raw materials

Raw materials

Preparation Products

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MLN-120B Suppliers

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783348-36-7, MLN-120BRelated Search:

MLN-8237

MLN120B;ML120B;MLN 120B;MLN-120B

N-(6-Chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methylnicotinamide

ML120B

MLN 120B

MLN120B

MLN-120B

N-(6-Chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methyl-3-pyridinecarboxamide

ML120B; MLN 120B; MLN-120B

3-Pyridinecarboxamide, N-(6-chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methyl-

MLN120B,ML120B,Inhibitor,I kappa B kinase,inhibit,IKK,IκB kinase,MLN-120B

ML 120B dihydrochloride(free base)

N-(6-chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methylpyridine-3-carboxamide

MLN120B, 10 mM in DMSO

MLN120B ，S7736

783348-36-7

NF-kB