ChemicalBook > CAS DataBase List > RAS-2410 hydrochloride

RAS-2410 hydrochloride

Product Name
RAS-2410 hydrochloride
CAS No.
1187075-34-8
Chemical Name
RAS-2410 hydrochloride
Synonyms
Resminostat HCl;RAS2410 hydrochloride;4SC-201 hydrochloride;RAS-2410 hydrochloride;RAS 2410 hydrochloride;ResMinostat (hydrochloride);Resminostat hydrochloride (4SC-201);RAS2410; 4SC-201; RAS 2410; RAS-2410;4SC201;4SC 201;RAS2410 HYDROCHLORIDE; 4SC-201 HYDROCHLORIDE; RAS 2410 HYDROCHLORIDE; RAS-2410 HYDROCHLORIDE;(2E)-3-[1-[[4-[(Dimethylamino)methyl]phenyl]sulfonyl]-1H-pyrrol-3-yl]-N-hydroxy-2-propenamide hydrochloride (1:1)
CBNumber
CB92666678
Molecular Formula
C16H20ClN3O4S
Formula Weight
385.8657
MOL File
1187075-34-8.mol
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RAS-2410 hydrochloride Property

storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
crystalline solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17553
Product name
Resminostat (hydrochloride)
Purity
≥95%
Packaging
1mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
17553
Product name
Resminostat (hydrochloride)
Purity
≥95%
Packaging
5mg
Price
$190
Updated
2024/03/01
Cayman Chemical
Product number
17553
Product name
Resminostat (hydrochloride)
Purity
≥95%
Packaging
10mg
Price
$310
Updated
2024/03/01
Cayman Chemical
Product number
17553
Product name
Resminostat (hydrochloride)
Purity
≥95%
Packaging
50mg
Price
$947
Updated
2024/03/01
ApexBio Technology
Product number
A3755
Product name
Resminostathydrochloride
Packaging
50mg
Price
$1010
Updated
2021/12/16
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RAS-2410 hydrochloride Chemical Properties,Usage,Production

Description

Resminostat is an orally bioavailable inhibitor of histone deacetylase 1 (HDAC1), HDAC3, and HDAC6 (IC50s = 43-72 nM), resulting in hyperacetylation of histone H4 in multiple myeloma cells. It abrogates cell growth and strongly induces apoptosis in multiple myeloma cells (IC50s = 2.5-3 μM). Resminostat displays synergistic effects when combined with melphalan and the proteasome inhibitors bortezomib and S-2209. It dose-dependently inhibits HDAC activity in vivo.

References

[1] mandl-weber s, meinel fg, jankowsky r, oduncu f, schmidmaier r, baumann p. the novel inhibitor of histone deacetylase resminostat (ras2410) inhibits proliferation and induces apoptosis in multiple myeloma (mm) cells. br j haematol. 2010 may;149(4):518-28.
[2] brunetto at, ang je, lal r, olmos d, molife lr, kristeleit r, parker a, casamayor i, olaleye m, mais a, hauns b, strobel v, hentsch b, de bono js. first-in-human, pharmacokinetic and pharmacodynamic phase i study of resminostat, an oral histone deacetylase inhibitor, in patients with advanced solid tumors. clin cancer res. 2013 oct 1;19(19):5494-504.

RAS-2410 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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RAS-2410 hydrochloride Suppliers

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View Lastest Price from RAS-2410 hydrochloride manufacturers

Zhejiang J&C Biological Technology Co.,Limited
Product
RAS-2410 hydrochloride 1187075-34-8
Price
US $0.00/gram
Min. Order
1gram
Purity
99%
Supply Ability
10kg
Release date
2022-02-18

1187075-34-8, RAS-2410 hydrochlorideRelated Search:


  • 4SC-201 hydrochloride
  • RAS 2410 hydrochloride
  • RAS2410 hydrochloride
  • RAS-2410 hydrochloride
  • ResMinostat (hydrochloride)
  • (2E)-3-[1-[[4-[(Dimethylamino)methyl]phenyl]sulfonyl]-1H-pyrrol-3-yl]-N-hydroxy-2-propenamide hydrochloride (1:1)
  • Resminostat HCl
  • RAS2410; 4SC-201; RAS 2410; RAS-2410;4SC201;4SC 201
  • Resminostat hydrochloride (4SC-201)
  • RAS2410 HYDROCHLORIDE; 4SC-201 HYDROCHLORIDE; RAS 2410 HYDROCHLORIDE; RAS-2410 HYDROCHLORIDE
  • RAS-2410,Resminostat hydrochloride,Resminostat,4SC-201,Histone deacetylases,Inhibitor,RAS 2410,inhibit,RAS2410,HDAC
  • 1187075-34-8
  • C16H19N3O4SHCl
  • APIs