ARN-2966
- Product Name
- ARN-2966
- CAS No.
- 102212-26-0
- Chemical Name
- ARN-2966
- Synonyms
- 2-PMAP;ARN-2966;ARN2966(2-PMAP);ARN-2966;ARN 2966;2-PMAP >=98% (HPLC);2-((pyridin-2-ylmethyl)amino)phenol;Phenol, 2-[(2-pyridinylmethyl)amino]-;ARN-2966,β-amyloid peptide,inhibit,Abeta,ARN 2966,Inhibitor,Amyloid-β,ARN2966
- CBNumber
- CB92667271
- Molecular Formula
- C12H12N2O
- Formula Weight
- 200.24
- MOL File
- 102212-26-0.mol
ARN-2966 Property
- Melting point:
- 130 °C(Solv: chloroform (67-66-3); hexane (110-54-3))
- Boiling point:
- 354.4±27.0 °C(Predicted)
- Density
- 1.241±0.06 g/cm3(Predicted)
- storage temp.
- Desiccate at -20°C
- solubility
- Soluble in DMSO
- form
- Powder
- pka
- 10.22±0.35(Predicted)
N-Bromosuccinimide Price
- Product number
- 21021
- Product name
- 2-PMAP
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 21021
- Product name
- 2-PMAP
- Packaging
- 5mg
- Price
- $100
- Updated
- 2024/03/01
- Product number
- 21021
- Product name
- 2-PMAP
- Packaging
- 10mg
- Price
- $184
- Updated
- 2024/03/01
- Product number
- 21021
- Product name
- 2-PMAP
- Packaging
- 25mg
- Price
- $396
- Updated
- 2024/03/01
- Product number
- SYN5152
- Product name
- 2-PMAP
- Packaging
- 50mg
- Price
- $765
- Updated
- 2021/12/16
ARN-2966 Chemical Properties,Usage,Production
Biological Activity
arn2966 is a potent post-transcriptional modulator of amyloid precursor protein (app) expression in transfected cho cells. the cho cell can produce app.[1]app is the amyloid precursor protein of alzheimer’s disease. alzheimer’s disease is a progressive dementia with the symptoms of neuronal degeneration, synaptic loss, and the deposition of amyloid fibrils in the brain. ab protein is the major constituent of the amyloid . then the ab protein derives from the amyloid precursor protein (app). it has been proved that app can stimulate neurite outgrowth in vitro. [2]the modulation of app expression of the arn2966 functions as a post-transcriptional modulation,which is different from other mechanisms such as inhibition of secretases. arn2966 showed dose dependant inhibition of aß40 and aß42 productions in app751sw transfected cho cells (ic50<1 mm for aß40), along with lowering the level of app and c83, and c99 peptides, while the level of app mrna was unaffected..[1]there has been ad transgenic mice model proved arn2966’s efficacy and tolerability in vivo. through the treatment of arn2966, the memory of mice has been improved and a load in the brain has been reduced.
References
[1] ayodeji asuni ,xu kevin , etal. , an app translation modulator arn2966 reduces beta-amyloid deposition and prevents memory deficits in alzheimer's disease transgenic mice. alzheimer's & dementia: the journal of the alzheimer's association, july 2012volume 8, issue 4, supplement, page s744 ;
[2]williamson tg1, mok ss, henry a, etal. , secreted glypican binds to the amyloid precursor protein of alzheimer's disease (app) and inhibits app-induced neurite outgrowth. j biol chem. 1996 dec 6;271(49):31215-21.
ARN-2966 Preparation Products And Raw materials
Raw materials
Preparation Products
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