ChemicalBook > CAS DataBase List > 2-Naphthalenecarboxylic acid, 3-hydroxy-, 2-[(2,4,5-trihydroxyphenyl)Methylene]hydrazide

2-Naphthalenecarboxylic acid, 3-hydroxy-, 2-[(2,4,5-trihydroxyphenyl)Methylene]hydrazide

Product Name: 2-Naphthalenecarboxylic acid, 3-hydroxy-, 2-[(2,4,5-trihydroxyphenyl)Methylene]hydrazide
CAS No.: 1256493-34-1
Chemical Name: 2-Naphthalenecarboxylic acid, 3-hydroxy-, 2-[(2,4,5-trihydroxyphenyl)Methylene]hydrazide
Synonyms: o-4a;Dyng;Dyngo-49;Dyngo-4a;Hydroxy-Dynasore;Hydroxy-Dynasore, 10 mM in DMSO;Dyngo 4a, Novel, highly potent dynamin inhibitor;3-Hydroxy-N'-(2,4,5-trihydroxybenzylidene)-2-naphthohydrazide;3-Hydroxy-N′-[(2,4,5-trihydroxyphenyl)methylidene]naphthalene-2-carbohydrazide;3-Hydroxy-2-naphthalenecarboxylic acid 2-[(2,4,5-trihydroxyphenyl)methylene]hydrazide
CBNumber: CB92668283
Molecular Formula: C18H14N2O5
Formula Weight: 338.31
MOL File: 1256493-34-1.mol

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2-Naphthalenecarboxylic acid, 3-hydroxy-, 2-[(2,4,5-trihydroxyphenyl)Methylene]hydrazide Property

Density: 1.45±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: >10mg/mL
pka: 8.28±0.40(Predicted)
form: powder
color: faint yellow to dark yellow

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Safety

Hazard Codes: N
Risk Statements: 50
Safety Statements: 61
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H361Suspected of damaging fertility or the unborn child

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0340
Product name: Hydroxy-Dynasore
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $124.45
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0340
Product name: Hydroxy-Dynasore
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $363.3
Updated: 2025/07/31

Cayman Chemical

Product number: 29479
Product name: Dyngo-4a
Packaging: 10mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 29479
Product name: Dyngo-4a
Packaging: 100mg
Price: $714
Updated: 2024/03/01

Cayman Chemical

Product number: 29479
Product name: Dyngo-4a
Packaging: 5mg
Price: $62
Updated: 2024/03/01

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2-Naphthalenecarboxylic acid, 3-hydroxy-, 2-[(2,4,5-trihydroxyphenyl)Methylene]hydrazide Chemical Properties,Usage,Production

Uses

Hydroxy-Dynasore is an inhibitor of dynamin I and dynamin II.

Definition

ChEBI: Dyngo-4a is dynamin inhibitor. It has a role as an EC 3.6.5.5 (dynamin GTPase) inhibitor.

Biochem/physiol Actions

Hydroxy-Dynasore is a cell permeable and potent dynamin inhibitor that prevents uptake of recombinant botulinum neurotoxin A heavy chain binding domain (BoNT/A-Hc). Apparently, Hydroxy-Dynasore prevents dynamin-mediated fission of endocytic vesicles from the plasma membrane.

in vivo

Hydroxy Dynasore (intraperitoneal injection; 30 mg/kg; 1.5-2 h before BoNT/A injection) provides protection again BoNT/A-induced paralysis in the phrenic nerve-hemidiaphragm twitch model in CD-1 mice^[2].

Animal Model:	CD-1 mice^[2].
Dosage:	30 mg/kg
Administration:	Intraperitoneal injection; 1.5–2 h before BoNT/A injection
Result:	Protected BoNT/A-induced paralysis in vivo.

storage

Store at -20°C

2-Naphthalenecarboxylic acid, 3-hydroxy-, 2-[(2,4,5-trihydroxyphenyl)Methylene]hydrazide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Naphthalenecarboxylic acid, 3-hydroxy-, 2-[(2,4,5-trihydroxyphenyl)Methylene]hydrazide manufacturers

Career Henan Chemical Co

Product: 2-Naphthalenecarboxylic acid, 3-hydroxy-, 2-[(2,4,5-trihydroxyphenyl)Methylene]hydrazide 1256493-34-1
Price: US $1.00/g
Min. Order: 1g
Purity: 99.99%
Supply Ability: 200kg
Release date: 2019-12-24

1256493-34-1, 2-Naphthalenecarboxylic acid, 3-hydroxy-, 2-[(2,4,5-trihydroxyphenyl)Methylene]hydrazideRelated Search:

2-Naphthalenecarboxylic acid, 3-hydroxy-, 2-[(2,4,5-trihydroxyphenyl)Methylene]hydrazide

Dyngo-49

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Dyngo 4a, Novel, highly potent dynamin inhibitor

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1256493-34-1