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IMiquiMod (hydrochloride)

Product Name
IMiquiMod (hydrochloride)
CAS No.
99011-78-6
Chemical Name
IMiquiMod (hydrochloride)
Synonyms
IMiquiMod (hydrochloride);Imiquimod hydrochloride (R 837 hydrochloride);1-Isobutyl-1H-imidazo[4,5-c]quinolin-4-amine hydrochloride;1-Isobutyl-1H-imidazo[4,5-c]quinolin-4-amine hydrochloride , Imiquimod HCl
CBNumber
CB92682005
Molecular Formula
C14H17ClN4
Formula Weight
276.76458
MOL File
99011-78-6.mol
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IMiquiMod (hydrochloride) Property

Melting point:
>300 °C
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
≥3.59 mg/mL in EtOH with ultrasonic; ≥5.54 mg/mL in DMSO with gentle warming and ultrasonic; ≥7.34 mg/mL in H2O with ultrasonic
form 
solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ApexBio Technology
Product number
B1186
Product name
Imiquimodhydrochloride
Packaging
100mg
Price
$50
Updated
2021/12/16
ChemScene
Product number
CS-2059
Product name
Imiquimod(hydrochloride)
Purity
99.80%
Packaging
100mg
Price
$60
Updated
2021/12/16
ChemScene
Product number
CS-2059
Product name
Imiquimod(hydrochloride)
Purity
99.80%
Packaging
200mg
Price
$78
Updated
2021/12/16
ChemScene
Product number
CS-2059
Product name
Imiquimod(hydrochloride)
Purity
99.80%
Packaging
500mg
Price
$137
Updated
2021/12/16
CSNpharm
Product number
CSN18646
Product name
ImiquimodHCl
Packaging
100mg
Price
$51
Updated
2021/12/16
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IMiquiMod (hydrochloride) Chemical Properties,Usage,Production

Uses

Imiquimod hydrochloride (R 837 hydrochloride), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. Imiquimod hydrochloride exhibits antiviral and antitumor effects in vivo. Imiquimod hydrochloride can be used for the research of external genital, perianal warts, cancer and COVID-19[1][2].

Biological Activity

imiquimod hydrochloride is an immune response modifier that acts as a toll-like receptor 7 agonist and is commonly used topically to treat warts on the skin of the genital and anal areas.

in vivo

In animal models, Imiquimod hydrochloride stimulates the innate immune response by increasing NK cell activity, activating macrophages to secretecytokines and nitric oxide, and inducing proliferation and differentiation of B lymphocytes. Imiquimod hydrochloride stimulates the innate immune response through induction, synthesis, and release of cytokines, including interferon-a (IFN-α), interleukin (IL)-6, and tumor necrosis factor (TNF)-α.

target

TLR7

HSV-1

IC 50

TLR7; HSV-1

References

[1] Athina Angelopoulou, et al. Imiquimod - A toll like receptor 7 agonist - Is an ideal option for management of COVID 19. Environ Res. 2020 Sep; 188: 109858. DOI:10.1016/j.envres.2020.109858
[2] Yuji Kan, et al. Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway. J Virol. 2012 Oct;86(19):10338-46. DOI:10.1128/JVI.01196-12
[3] Aditya K Gupta, et al. Imiquimod: a review. J Cutan Med Surg. Nov-Dec 2002;6(6):554-60. DOI:10.1007/s10227-001-0134-6
[4] Michael P Sch?n, et al. The small antitumoral immune response modifier imiquimod interacts with adenosine receptor signaling in a TLR7- and TLR8-independent fashion. J Invest Dermatol. 2006 Jun;126(6):1338-47. DOI:10.1038/sj.jid.5700286

IMiquiMod (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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IMiquiMod (hydrochloride) Suppliers

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99011-78-6, IMiquiMod (hydrochloride)Related Search:


  • IMiquiMod (hydrochloride)
  • Imiquimod hydrochloride (R 837 hydrochloride)
  • 1-Isobutyl-1H-imidazo[4,5-c]quinolin-4-amine hydrochloride
  • 1-Isobutyl-1H-imidazo[4,5-c]quinolin-4-amine hydrochloride , Imiquimod HCl
  • 99011-78-6