ChemicalBook > CAS DataBase List > diMethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5-
diMethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5-
- Product Name
- diMethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5-
- CAS No.
- 1246616-66-9
- Chemical Name
- diMethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5-
- Synonyms
- Dolutegravir DL4B;Dolutegravir Intermediate3;diMethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5-;Dimethyl 4-oxo-3-benzyloxy-4H-pyran-2,5-dicarboxyl;imethyl3-(benzyloxy)-4-oxo-4H-pyran-2,5-dicarboxylate;TIANFUCHEM diMethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5-;Dimethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5-dicarboxylate;4-Oxo-3-benzyloxy-4H-pyran-2,5-dicarboxylic acid dimethyl ester;4-Oxo-3-(phenylMethoxy)-4H-pyran-2,5-dicarboxylic acid 2,5-diMethyl ester;4H-Pyran-2,5-dicarboxylic acid, 4-oxo-3-(phenylmethoxy)-, 2,5-dimethyl ester
- CBNumber
- CB92685293
- Molecular Formula
- C16H14O7
- Formula Weight
- 318.28
- MOL File
- 1246616-66-9.mol
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diMethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5- Property
- Boiling point:
- 534.9±50.0 °C(Predicted)
- Density
- 1.34±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
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N-Bromosuccinimide Price
TRC
- Product number
- D470946
- Product name
- Dimethyl3-(benzyloxy)-4-oxo-4H-pyran-2,5-dicarboxylate
- Packaging
- 500mg
- Price
- $215
- Updated
- 2021/12/16
Ambeed
- Product number
- A117478
- Product name
- Dimethyl3-(benzyloxy)-4-oxo-4H-pyran-2,5-dicarboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $12
- Updated
- 2021/12/16
Ambeed
- Product number
- A117478
- Product name
- Dimethyl3-(benzyloxy)-4-oxo-4H-pyran-2,5-dicarboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $39
- Updated
- 2021/12/16
Acrotein
- Product number
- H-7797
- Product name
- Dimethyl3-(benzyloxy)-4-oxo-4H-pyran-2,5-dicarboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $82.5
- Updated
- 2021/12/16
Crysdot
- Product number
- CD11316840
- Product name
- Dimethyl3-(benzyloxy)-4-oxo-4H-pyran-2,5-dicarboxylate
- Purity
- 95+%
- Packaging
- 25g
- Price
- $161
- Updated
- 2021/12/16
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diMethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5- Chemical Properties,Usage,Production
Uses
Dimethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5-dicarboxylate is a useful intermediate for the preparation of dolutegravir and dolutegravir salts used in antiretroviral medications.
Synthesis
553-90-2
1246616-65-8
1246616-66-9
To a reaction flask was added 30 mmol of methyl 4-benzyloxy-2-((dimethylamino)methylene)-3-acetoacetate (product of Example 2), 45 mmol of dimethyl oxalate, 15 mmol of sodium tert-butanol and 300 mL of toluene. The reaction flask was placed in an oil bath, heated to 105 °C and refluxed for 6 hours. After the reaction was completed, it was cooled to room temperature and filtered. The toluene solvent was removed by rotary evaporation to obtain the crude product. The crude product was purified by column chromatography with the eluent hexane:ethyl acetate=9:4 (v/v) to afford dimethyl 4-oxo-3-benzyloxy-4H-pyran-2,5-dicarboxylate in 90% yield.
References
[1] Patent: CN108101838, 2018, A. Location in patent: Paragraph 0038; 0039; 0040; 0041
[2] Patent: US2012/22251, 2012, A1. Location in patent: Page/Page column 24-25
[3] Patent: EP2602260, 2013, A1. Location in patent: Paragraph 0124
diMethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5- Preparation Products And Raw materials
Raw materials
Preparation Products
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diMethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5- Suppliers
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View Lastest Price from diMethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5- manufacturers
Henan Aochuang Chemical Co.,Ltd.
- Product
- 4-Oxo-3-(phenylmethoxy)-4h-pyran-2,5-dicarboxylic acid 2,5-dimethyl ester 1246616-66-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-30
Henan Fengda Chemical Co., Ltd
- Product
- diMethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5- 1246616-66-9
- Price
- US $6.00-0.50/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-03-22
Career Henan Chemical Co
- Product
- diMethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5- 1246616-66-9
- Price
- US $7.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-12-18
1246616-66-9, diMethyl 3-(benzyloxy)-4-oxo-4H-pyran-2,5-Related Search:
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