Moxonidine (hydrochloride)
- Product Name
- Moxonidine (hydrochloride)
- CAS No.
- 75536-04-8
- Chemical Name
- Moxonidine (hydrochloride)
- Synonyms
- BDF5895 hydrochloride;Moxonidine HCl - Bio-X ?;Moxonidine hydrochloride CP;MOXONIDINE HYDROCHLORIDE CP; MOXONIDINE HCL; BDF-5895 HCL;Moxonidine hydrochloride, I1 Imidazoline receptor and alpha2 adrenergic agonist
- CBNumber
- CB92685930
- Molecular Formula
- C9H13Cl2N5O
- Formula Weight
- 278.14
- MOL File
- 75536-04-8.mol
Moxonidine (hydrochloride) Property
- form
- Solid
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- H810
- Product name
- MoxonidineHCl
- Packaging
- 5mg
- Price
- $19
- Updated
- 2021/12/16
- Product number
- H810
- Product name
- MoxonidineHCl
- Packaging
- 25mg
- Price
- $30
- Updated
- 2021/12/16
- Product number
- H810
- Product name
- MoxonidineHCl
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- BM164613
- Product name
- Moxonidine hydrochloride
- Packaging
- 10mg
- Price
- $72
- Updated
- 2021/12/16
- Product number
- H810
- Product name
- MoxonidineHCl
- Packaging
- 500mg
- Price
- $175
- Updated
- 2021/12/16
Moxonidine (hydrochloride) Chemical Properties,Usage,Production
Uses
Moxonidine Hydrochloride is a selective agonist at the imidazoline receptor subtype 1, used as antihypertensive agent. Target: I1-R Moxonidine Hydrochloride is a centrally acting antihypertensive agent. Mixed Nischarin (I1 imidazoline receptor) and α2-AR (adrenergic) agonist; displays 40-fold higher affinity for I1 receptors versus α2-adrenoceptors. Moxonidine reduced stimulated NE overflow (log EC50: -6.15 +/- 0.14). AGN192403, a selective ligand at I1-R, had no influence on the dose-response curve of moxonidine (log EC50: -6.01 +/- 0.25) [1]. The hypotensive and bradycardic actions of moxonidine but not clonidine are mediated through imidazoline receptors and are dependent on intact noradrenergic pathways within the RVLM. Furthermore, the noradrenergic innervation may be associated with a 42 kDa imidazoline receptor protein [2].
References
[1] Schafer, U., et al., Presynaptic effects of moxonidine in isolated buffer perfused rat hearts: role of imidazoline-1 receptors and alpha2-adrenoceptors. J Pharmacol Exp Ther, 2002. 303(3): p. 1163-70. DOI:10.1124/jpet.102.041657
[2] Chan, C.K., et al., Imidazoline receptors associated with noradrenergic terminals in the rostral ventrolateral medulla mediate the hypotensive responses of moxonidine but not clonidine. Neuroscience, 2005. 132(4): p. 991-1007. DOI:10.1016/j.neuroscience.2005.01.032
Moxonidine (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
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