ChemicalBook > CAS DataBase List > 2-Bromo-6-(difluoromethyl)pyridine
2-Bromo-6-(difluoromethyl)pyridine
- Product Name
- 2-Bromo-6-(difluoromethyl)pyridine
- CAS No.
- 872365-91-8
- Chemical Name
- 2-Bromo-6-(difluoromethyl)pyridine
- Synonyms
- 2-Bromo-6-(difluoromethyl)pyridine;Pyridine, 2-bromo-6-(difluoromethyl)-;2-Bromo-6-(difluoromethyl)pyridine 95%;2-Bromo-6-(difluoromethyl)pyridine 95+%;6-Bromo-alpha,alpha-difluoro-2-picoline
- CBNumber
- CB92688340
- Molecular Formula
- C6H4BrF2N
- Formula Weight
- 208
- MOL File
- 872365-91-8.mol
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2-Bromo-6-(difluoromethyl)pyridine Property
- Density
- 1.703 g/mL at 25 °C
- refractive index
- 1.520
- Flash point:
- 110℃
- storage temp.
- 2-8°C
- form
- liquid
- Appearance
- Colorless to light yellow Liquid
- InChI
- InChI=1S/C6H4BrF2N/c7-5-3-1-2-4(10-5)6(8)9/h1-3,6H
- InChIKey
- ZTBGDNNRDRISQZ-UHFFFAOYSA-N
- SMILES
- C1(Br)=NC(C(F)F)=CC=C1
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Safety
- Hazard Codes
- T
- Risk Statements
- 25-36/37/38
- Safety Statements
- 26-45
- RIDADR
- UN 2810 6.1 / PGIII
- WGK Germany
- 3
- HazardClass
- 6.1
- HS Code
- 2933399990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 741302
- Product name
- 2-Bromo-6-(difluoromethyl)pyridine
- Purity
- 95%
- Packaging
- 1g
- Price
- $53.5
- Updated
- 2025/07/31
TRC
- Product number
- B699780
- Product name
- 2-Bromo-6-(difluoromethyl)pyridine
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
AK Scientific
- Product number
- 1187AF
- Product name
- 2-Bromo-6-(difluoromethyl)pyridine
- Packaging
- 1g
- Price
- $116
- Updated
- 2021/12/16
Apolloscientific
- Product number
- PC49145
- Product name
- 2-Bromo-6-(difluoromethyl)pyridine
- Purity
- 95+%
- Packaging
- 5g
- Price
- $127
- Updated
- 2021/12/16
Apolloscientific
- Product number
- PC49145
- Product name
- 2-Bromo-6-(difluoromethyl)pyridine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $28
- Updated
- 2021/12/16
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2-Bromo-6-(difluoromethyl)pyridine Chemical Properties,Usage,Production
Synthesis
34160-40-2
872365-91-8
Step 3. Preparation of 2-bromo-6-(difluoromethyl)pyridine To a solution of 6-bromopyridine-2-carbaldehyde (2.10 g, 11.29 mmol) in dichloromethane (20 mL) was slowly added diethylamino sulfur trifluoride (1.94 mL, 14.68 mmol) at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 18 hours. Upon completion of the reaction, the mixture was carefully poured into pre-cooled saturated sodium bicarbonate solution (300 mL). Extraction was carried out with ethyl acetate (2 x 120 mL) and the organic phases were combined. Subsequently, the organic phase was washed sequentially with saturated sodium bicarbonate solution (80 mL) and brine (2 x 50 mL), dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure to afford 2-bromo-6-(difluoromethyl)pyridine as a brown oil (2.17 g, 89% yield). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 7.75-7.70 (m, 1H), 7.65-7.60 (m, 2H), 6.60 (t, J = 55.1 Hz, 1H).
References
[1] Patent: WO2017/201468, 2017, A1. Location in patent: Page/Page column 236
[2] Patent: WO2017/80979, 2017, A1. Location in patent: Page/Page column 124; 125
[3] Patent: US2009/253750, 2009, A1. Location in patent: Page/Page column 9
[4] Patent: US2016/221998, 2016, A1. Location in patent: Paragraph 0396; 0397
2-Bromo-6-(difluoromethyl)pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Bromo-6-(difluoromethyl)pyridine manufacturers
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
- Product
- 2-Bromo-6-(difluoromethyl)pyridine 872365-91-8
- Price
- US $2.20-8.80/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-17