(6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-Methyl-spiro[androsta-1,4-diene-17,5'-[1,3]oxathiolane]-2',3,4'-trione

Product Name: (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-Methyl-spiro[androsta-1,4-diene-17,5'-[1,3]oxathiolane]-2',3,4'-trione
CAS No.: 219719-95-6
Chemical Name: (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-Methyl-spiro[androsta-1,4-diene-17,5'-[1,3]oxathiolane]-2',3,4'-trione
Synonyms: Fluticasone USP RC B;Fluticasone Impurity 54;Fluticasone Propionate RC B;Fluticasone Trioxo Impurity;luticasone Related Compound B;Fluticasone Related CoMpound B;Fluticasone USP Related Compound B;(5'R,6S,8S,9R,10S,11S,13S,14S,16R);Fluticasone propionate impurity 48;Fluticasone Impurity 10(Fluticasone USP RC B)
CBNumber: CB92694572
Molecular Formula: C22H24F2O5S
Formula Weight: 438.48
MOL File: 219719-95-6.mol

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(6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-Methyl-spiro[androsta-1,4-diene-17,5'-[1,3]oxathiolane]-2',3,4'-trione Property

Melting point:: >125°C (dec.)
Boiling point:: 562.1±60.0 °C(Predicted)
Density: 1.43±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
form: Solid
pka: 12.93±0.70(Predicted)
color: Off-White to Pale Beige
Major Application: pharmaceutical
InChIKey: IYYYTOVWCWEIIH-OGWMHLGRNA-N
SMILES: C1=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@]4(C)[C@]5(OC(=O)SC5=O)[C@H](C)C[C@H]4[C@@H]3C[C@H](F)C2=CC1=O |&1:2,4,6,9,11,18,21,22,24,r|

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Sens. 1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR8878
Product name: Fluticasone Related Compound B
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 100 mg
Price: $905
Updated: 2026/03/19

TRC

Product number: D446130
Product name: (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-spiro[androsta-1,4-diene-17,5''-[1,3]oxathiolane]-2'',3,4''-trione
Packaging: 10mg
Price: $95
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 69518
Product name: (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-spiro[androsta-1,4-diene-17,5??-[1,3]oxathiolane]-2??,3,4??-trione
Packaging: 500mg
Price: $2400
Updated: 2021/12/16

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(6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-Methyl-spiro[androsta-1,4-diene-17,5'-[1,3]oxathiolane]-2',3,4'-trione Chemical Properties,Usage,Production

Uses

An impurity of Fluticasone Propionate (F599500), a derivative of Flumethasone (F455000). An antiallergic; anti-asthmatic; anti-inflammatory. Fluticasone USP Related Compound B.

(6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-Methyl-spiro[androsta-1,4-diene-17,5'-[1,3]oxathiolane]-2',3,4'-trione Preparation Products And Raw materials

Raw materials

Preparation Products

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(6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-Methyl-spiro[androsta-1,4-diene-17,5'-[1,3]oxathiolane]-2',3,4'-trione Suppliers

Canada 1 China 48 India 4 United States 3 Global 56

hubei PharmaStandard Co., Ltd.

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J & K SCIENTIFIC LTD.

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Fax: 86-10-82849933
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Shenzhen Polymeri Biochemical Technology Co., Ltd.

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Shenzhen Botel Biotechnology Co. Ltd.

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Guangzhou Dreampharm Biotechnology Co., Ltd.

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219719-95-6, (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-Methyl-spiro[androsta-1,4-diene-17,5'-[1,3]oxathiolane]-2',3,4'-trioneRelated Search:

Fluticasone Finasteride 11-Oxo Fluticasone Propionate Fluticasone Fluticasone Acetate Fluticasone 5-Chloromethyl 6a,9a-Difluoro-11-hydroxy-16a-methyl-3-oxo-17a-(propionyloxy)-androsta-1,4-diene-17-carbothioate (6α,11β,16α,17α)-(6'α,11'β,16'α,17'α)-17,17'-(Trithiodicarbonyl)bis[6,9-difluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-androsta-1,4-dien-3-one DesfluoroMethyl Fluticasone Propionate Disulfide Fluticasone IMpurity (1-oxopropoxy)-, S-(fluoromethyl)ester, (6α,11β,16α,17α)- (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid Fluticasone propionate Fluticasone propionate-d5 Fluticasone EP IMpurity B FLUTICASONE PROPIONATE INTERMEDIATE 5-Iodomethyl 6a,9a-Difluoro-11-hydroxy-16a-methyl-3-oxo-17a-(propionyloxy)-androsta-1,4-diene-17-carbothioate Ticabesone Propionate

(6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-Methyl-spiro[androsta-1,4-diene-17,5'-[1,3]oxathiolane]-2',3,4'-trione

Fluticasone Related CoMpound B

Fluticasone USP RC B

Fluticasone Impurity 10(Fluticasone USP RC B)

6alpha,9alpha-Difluoro-11beta-hydroxy-16alpha-methyl-2',3,4'-trioxo-17alpha-spiro(androsta-1,4-diene-17,5'-(1,3)oxathiolane)

(5R,6'S,8'S,9'R,10'S,11'S,13'S,14'S,16'R)-6',9'-difluoro-11'-hydroxy-10',13',16'-trimethylspiro[1,3-oxathiolane-5,17'-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene]-2,3',4-trione

Fluticasone USP Related Compound B/Fluticasone Trioxo Impurity/6α,9α-Difluoro-11β-hydroxy-16α-methyl-2',3,4'-trioxo-17α-spiro(androsta-1,4-diene-17,5'-(1,3)oxathiolane)

(5'R,6S,8S,9R,10S,11S,13S,14S,16R)

Fluticasone USP Related Compound B

Spiro[androsta-1,4-diene-17,5'-[1,3]oxathiolane]-2',3,4'-trione, 6,9-difluoro-11-hydroxy-16-methyl-, (6α,11β,16α,17α)- (9CI)

Fluticasone Related Compound B (Fluticasone Trioxo Impurity)

Fluticasone Propionate RC B

(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-7,8,9,10,11,12,13,14,15,16-decahydrospiro[cyclopenta[a]phenanthrene-17,5'-[1,3]oxathiolane]-2',3,4'(6H)-trione

(6a,11β,16a,17a)-6,9-Difluoro-11-hydroxy-16-methyl-spiro[androsta-1,4-diene-17,5-[1,3]oxathiolane]-

Fluticasone Trioxo Impurity

Fluticasone Propionate USP Related Compound B

Spiro[androsta-1,4-diene-17,5′-[1,3]oxathiolane]-2′,3,4′-trione, 6,9-difluoro-11-hydroxy-16-methyl-, (6α,11β,16α,17α)-

Fluticasone Impurity 54

(6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-spiro[androstα-1,4-diene-17,5'-[1,3]oxathiolane]-2',3,4'-trione

luticasone Related Compound B

6alpha,9alpha-Difluoro-11beta-hydroxy-16alpha-methyl-2',3,4'-trioxo-17alpha-spiro(androsta-1,4-diene

(6Alpha,11Beta,16Alpha,17Alpha)-6,9-Difluoro-11-hydroxy-16-methyl-spiro[androsta-1,4-diene-17,5'-[1,3]oxathiolane]-2',3,4'-trione

Fluticasone propionate impurity 48

219719-95-6

C22H24F2O5S

Pharmaceuticals, Intermediates & Fine Chemicals, Steroids