1-Methyl-1H-pyrazole-3-carboxamide

1-Methyl-1H-pyrazole-3-carboxamide Property

Melting point:

139-141 °C

Boiling point:

349.3±15.0 °C(Predicted)

Density 

1.34±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

15.73±0.50(Predicted)

Appearance

White to off-white Solid

Safety

HS Code 

2933199090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

1-Methyl-1H-pyrazole-3-carboxamide Chemical Properties,Usage,Production

Synthesis

Step 3: To a solution of dichloromethane (50 mL) of the intermediate (6.0 g, 47.6 mmol) obtained in Step 2 was slowly added oxalyl chloride (6.12 mL, 71.4 mmol) and a catalytic amount of N,N-dimethylformamide (0.5 mL) at 0 °C. The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure and the resulting residue was redissolved in dichloromethane. Ammonia was passed into the solution for 30 min at 0°C. Subsequently, the reaction mixture was concentrated again under reduced pressure and the residue was suspended in tetrahydrofuran (50 mL) and filtered. The filtrate was concentrated under reduced pressure to afford the target product 1-methyl-1H-pyrazole-3-carboxamide (3.5 g, 59% yield).LC-MS (Method 3): m/z [M + H]+ = 126 (theoretical molecular weight = 125.13); retention time R = 0.76 min.

References

[1] Patent: WO2015/22073, 2015, A1. Location in patent: Page/Page column 90; 91
[2] Patent: WO2014/139150, 2014, A1
[3] Patent: WO2014/150114, 2014, A1