4,5-dichloro-2-iodobenzenaMine
- Product Name
- 4,5-dichloro-2-iodobenzenaMine
- CAS No.
- 220185-63-7
- Chemical Name
- 4,5-dichloro-2-iodobenzenaMine
- Synonyms
- 185568;2-Iodo-4,5-dichloroaniline;4,5-Dichloro-2-iodoaniline;4,5-dichloro-2-iodobenzenaMine;Benzenamine, 4,5-dichloro-2-iodo-
- CBNumber
- CB92703603
- Molecular Formula
- C6H4Cl2IN
- Formula Weight
- 287.91
- MOL File
- 220185-63-7.mol
4,5-dichloro-2-iodobenzenaMine Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- Appearance
- Off-white to gray Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 1644CS
- Product name
- 4,5-Dichloro-2-iodoaniline
- Packaging
- 100mg
- Price
- $127
- Updated
- 2021/12/16
- Product number
- 1644CS
- Product name
- 4,5-Dichloro-2-iodoaniline
- Packaging
- 5g
- Price
- $810
- Updated
- 2021/12/16
- Product number
- A142826
- Product name
- 4,5-Dichloro-2-iodoaniline
- Purity
- 98%
- Packaging
- 250mg
- Price
- $16
- Updated
- 2021/12/16
- Product number
- A142826
- Product name
- 4,5-Dichloro-2-iodoaniline
- Purity
- 98%
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- D1018-00-N
- Product name
- 4,5-dichloro-2-iodoaniline
- Purity
- 95%
- Packaging
- 100mg
- Price
- $188
- Updated
- 2021/12/16
4,5-dichloro-2-iodobenzenaMine Chemical Properties,Usage,Production
Synthesis
95-76-1
220185-63-7
The general procedure for the synthesis of 4,5-dichloro-2-iodoaniline from 3,4-dichloroaniline is as follows: intermediate 20 - Preparation of 4,5-dichloro-2-iodoaniline. Iodine monochloride (1.39 mL, 27.77 mmol) was slowly added to a solution of 3,4-dichloroaniline (4.50 g, 27.77 mmol) in acetic acid (15 mL), and the reaction mixture was stirred at room temperature for 30 min. Upon completion of the reaction, the solution was concentrated to dryness under reduced pressure and the residue was neutralized with aqueous sodium bicarbonate, followed by extraction with dichloromethane. The organic layers were combined, washed with saturated sodium thiosulfate solution, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by fast column chromatography on silica gel (eluent: gradient elution of a heptane solution of 2% to 20% ethyl acetate) to give 4,5-dichloro-2-iodoaniline 3.46 g in 43% yield as a brown solid.1H NMR (DMSO-d6) δ 7.73 (s, 1H), 6.91 (s, 1H), 5.63 (br s, 2H).
References
[1] Tetrahedron Letters, 2004, vol. 45, # 46, p. 8569 - 8573
[2] Journal of Organic Chemistry, 2001, vol. 66, # 13, p. 4525 - 4542
[3] Tetrahedron Letters, 1998, vol. 39, # 51, p. 9347 - 9350
[4] Patent: WO2012/80220, 2012, A1. Location in patent: Page/Page column 77-78
[5] Patent: WO2012/80221, 2012, A1. Location in patent: Page/Page column 87
4,5-dichloro-2-iodobenzenaMine Preparation Products And Raw materials
Raw materials
Preparation Products
4,5-dichloro-2-iodobenzenaMine Suppliers
- Tel
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- Fax
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- sales@ajchem.in
- Country
- India
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