ChemicalBook > CAS DataBase List > Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate
Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate
- Product Name
- Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate
- CAS No.
- 1195768-19-4
- Chemical Name
- Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate
- Synonyms
- DABRAFENIB INT;Dalafenib intermediate 3;Methyl 3-(2,6-difluorophenylsulfonaMido)-2-fluorobenzoate;Methyl 3-{[(2,6-difluoropheyl)sulfonyl]aMino}-2-fluorabenzoate;methyl 3-(((2,6-difluorophenyl)sulfonyl)amino)-2-fluorobenzo...;Methyl 3-{[(2,6-difluorophenyl)sulfonyl]aMino}-2-fluorobenzoate;Benzoic acid, 3-[[(2,6-difluorophenyl)sulfonyl]amino]-2-fluoro-, methyl ester
- CBNumber
- CB92703779
- Molecular Formula
- C14H10F3NO4S
- Formula Weight
- 345.29
- MOL File
- 1195768-19-4.mol
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Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate Property
- Boiling point:
- 445.4±55.0 °C(Predicted)
- Density
- 1.507±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 6.68±0.10(Predicted)
- form
- Solid
- color
- White to Off-White
- InChI
- InChI=1S/C14H10F3NO4S/c1-22-14(19)8-4-2-7-11(12(8)17)18-23(20,21)13-9(15)5-3-6-10(13)16/h2-7,18H,1H3
- InChIKey
- COSCWKICERLCEK-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)C1=CC=CC(NS(C2=C(F)C=CC=C2F)(=O)=O)=C1F
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N-Bromosuccinimide Price
AK Scientific
- Product number
- 8353DN
- Product name
- Methyl3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate
- Packaging
- 250mg
- Price
- $123
- Updated
- 2021/12/16
Crysdot
- Product number
- CD12174605
- Product name
- Methyl3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $248
- Updated
- 2021/12/16
Crysdot
- Product number
- CD12174605
- Product name
- Methyl3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $743
- Updated
- 2021/12/16
Alichem
- Product number
- 1195768194
- Product name
- Methyl3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate
- Packaging
- 5g
- Price
- $787.5
- Updated
- 2021/12/16
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Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate Chemical Properties,Usage,Production
Uses
Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate can be useful in the development of B-RafV600E inhibitors.
Synthesis
Methyl 3-amino-2-fluorobenzoate was charged to the reactor, followed by dichloromethane. The contents were stirred and cooled to ~15°C, and pyridine was added. After that, the reactor contents were adjusted to ~15°C, and adding 2,6-diflurorobenzenesulfonyl chloride was started via an addition funnel. The temperature during addition was kept at <25°C. After complete addition, the reactor contents were warmed to 20-25°C and held overnight. Ethyl acetate was added, and dichloromethane was removed by distillation. Once distillation was complete, the reaction mixture was diluted again with ethyl acetate (5 vol) and concentrated. Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate was obtained through further purification.
storage
Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.
Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate manufacturers
Zison Pharmaceutical (Shandong) Co., Ltd.
- Product
- Methyl 3-(2,6-difluorophenylsulfonamido)-2-fluorobenzoate 1195768-19-4
- Price
- US $0.00/kg
- Min. Order
- 0.1kg
- Purity
- 99.9%
- Supply Ability
- 40-80kgs
- Release date
- 2024-05-24
Zibo Hangyu Biotechnology Development Co., Ltd
- Product
- Methyl 3-{[(2,6-difluoropheyl)sulfonyl]aMino}-2-fluorabenzoate 1195768-19-4
- Price
- US $50.00-500.00/kg
- Min. Order
- 10kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-10-30
Shaanxi Dideu Medichem Co. Ltd
- Product
- Methyl 3-{[(2,6-difluoropheyl)sulfonyl]aMino}-2-fluorabenzoate 1195768-19-4
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2020-04-27