ChemicalBook > CAS DataBase List > 3-Chloro-1H-pyrazol-5-aMine

3-Chloro-1H-pyrazol-5-aMine

Product Name: 3-Chloro-1H-pyrazol-5-aMine
CAS No.: 916211-79-5
Chemical Name: 3-Chloro-1H-pyrazol-5-aMine
Synonyms: EOS-61385;5-chloro-1H-pyrazol-3-aMine;3-Chloro-1H-pyrazol-5-aMine;5-Chloro-1H-Pyrazole-3-amine;1H-Pyrazol-3-amine, 5-chloro-
CBNumber: CB92704307
Molecular Formula: C3H4ClN3
Formula Weight: 117.54
MOL File: 916211-79-5.mol

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3-Chloro-1H-pyrazol-5-aMine Property

Boiling point:: 394.0±22.0 °C(Predicted)
Density: 1.562±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 12.32±0.10(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C3H4ClN3/c4-2-1-3(5)7-6-2/h1H,(H3,5,6,7)
InChIKey: HLMGWUFWDSUGRU-UHFFFAOYSA-N
SMILES: N1C(Cl)=CC(N)=N1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0050541
Product name: 5-Chloro-1H-pyrazol-3-amine
Purity: 99.01%
Packaging: 250mg
Price: $40
Updated: 2021/12/16

ChemScene

Product number: CS-0050541
Product name: 5-Chloro-1H-pyrazol-3-amine
Purity: 99.01%
Packaging: 1g
Price: $74
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0419673
Product name: 5-CHLORO-1H-PYRAZOL-3-AMINE
Purity: 95.00%
Packaging: 5MG
Price: $496.8
Updated: 2021/12/16

ChemScene

Product number: CS-0050541
Product name: 5-Chloro-1H-pyrazol-3-amine
Purity: 99.01%
Packaging: 10g
Price: $514
Updated: 2021/12/16

ChemScene

Product number: CS-0050541
Product name: 5-Chloro-1H-pyrazol-3-amine
Purity: 99.01%
Packaging: 5g
Price: $314
Updated: 2021/12/16

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3-Chloro-1H-pyrazol-5-aMine Chemical Properties,Usage,Production

Synthesis

1369959-12-5

916211-79-5

The general procedure for the synthesis of 5-chloro-1H-pyrazol-3-amine from 3-chloro-5-nitro-1H-pyrazole was as follows: tin(II) chloride (12.8 g, 68 mmol) was added batchwise to a methanol (200 mL) solution of 3-chloro-5-nitro-1H-pyrazole (2.0 g, 13.6 mmol). Concentrated hydrochloric acid (10 mL) was added slowly at 0°C. The reaction mixture was stirred at room temperature for 6 h. The organic solvent was subsequently removed by distillation under reduced pressure. The residue was diluted with distilled water (20 mL) and neutralized with sodium carbonate (Na2CO3) to pH 7. Subsequently, extraction was carried out with ethyl acetate (EtOAc, 3 × 50 mL). The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated to afford 5-chloro-1H-pyrazol-3-amine (1.4 g, 87% yield), which was used for subsequent reactions without further purification. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 11.55 (broad single peak, 1H), 5.26 (single peak, 2H), 5.21 (single peak, 1H).

References

[1] Journal of Medicinal Chemistry, 2012, vol. 55, # 7, p. 3036 - 3048
[2] Patent: WO2018/85247, 2018, A1. Location in patent: Paragraph 00296; 00300

3-Chloro-1H-pyrazol-5-aMine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-Chloro-1H-pyrazol-5-aMine manufacturers

Shaanxi Didu New Materials Co. Ltd

Product: 3-Chloro-1H-pyrazol-5-aMine 916211-79-5
Price: US $1.50/g
Min. Order: 1g
Purity: 99.0% Min
Supply Ability: 100 Tons
Release date: 2025-09-25

Career Henan Chemical Co

Product: 3-Chloro-1H-pyrazol-5-aMine 916211-79-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 500kg
Release date: 2018-08-19

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916211-79-5