Diphenylvinylsulfonium Triflate
- Product Name
- Diphenylvinylsulfonium Triflate
- CAS No.
- 247129-88-0
- Chemical Name
- Diphenylvinylsulfonium Triflate
- Synonyms
- Diphenyl(vinyl)sulfonium trifluoromethanesulfonate;Diphenylvinylsulfonium triflate;ethenyl(diphenyl)sulfanium;Sulfonium hanesulfonate (1:1);ethenyldiphenylsulfanium trifluoromethanesulfonate;SulfoniuM, ethenyldiphenyl-, 1,1,1-trifluoroMethanesulfonate;SulfoniuM, ethenyldiphenyl-, 1,1,1-trifluoroMethanesulfonate (1:1)
- CBNumber
- CB92704802
- Molecular Formula
- C15H13F3O3S2
- Formula Weight
- 362.38
- MOL File
- 247129-88-0.mol
Diphenylvinylsulfonium Triflate Property
- storage temp.
- Sealed in dry,Room Temperature
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- FD146166
- Product name
- Diphenylvinylsulfonium triflate
- Packaging
- 25mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- D6369
- Product name
- DiphenylvinylsulfoniumTriflate
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- FD146166
- Product name
- Diphenylvinylsulfonium triflate
- Packaging
- 50mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- FD146166
- Product name
- Diphenylvinylsulfonium triflate
- Packaging
- 100mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- FD146166
- Product name
- Diphenylvinylsulfonium triflate
- Packaging
- 500mg
- Price
- $300
- Updated
- 2021/12/16
Diphenylvinylsulfonium Triflate Chemical Properties,Usage,Production
Description
Diphenylvinylsulfonium Triflate is a pale yellow, oily organic compound. It has a vinylsulfonium salt structure, and nucleophiles readily undergo conjugate addition reactions with vinylsulfonium salts to form thionimide intermediates, which can undergo a series of further transformations. Applications in epoxidation, azide and other cyclisation reactions have demonstrated the broad applicability of vinyl sulfonium salts as two-carbon bridges.
Uses
Diphenylvinylsulfonium Triflate can be used as GLP-??1r modulating compounds to treat GLP-??1R mediated diseases such as metabolic and related diseases, including but not limited to NASH, obesity, and type 2 diabetes.
Synthesis
Diphenylvinylsulfonium Triflate is synthesised using (2-bromoethyl)diphenylsulfonium trifluoromethanesulfonate as a raw material by chemical reaction. The specific synthesis steps are as follows:
INTERMEDIATE 75(DiphenylXvmyDsulfonium trifluoromethanesulfonateIntermediate 74 (11.4 g, 25.7 mmol) was dissolved in THF/H2O (2:1) (42 mL). KHCO3 (3.1 g, 30.9 mmol) was added and the reaction mixture was stirred for 20 minutes at r.t. The solvent was evaporated immediately under reduced pressure (using a rotary evaporator connected to a high vacuum pump and keeping the water-bath temperature below 2O0C). The reaction mixture was then redissolved in DCM (40 mL), dried over MgSO4, filtered and evaporated. The residue was redissolved in DCM (10 mL) and loaded onto a silica bed (4 cm depth and 2.5 cm diameter). The resulting band was covered with 1 cm sand and eluted with DCM (400 mL), followed by 10% MeOH in DCM (200 mL). The product was isolated as a light brown oil (9.53 g, quantitative). 6H (CDCl3) 7.90-7.87 (4H, m), 7.79-7.66 (6H, m), 7.53 (IH, dd, J 8.8, 8.8 Hz), 6.69 (IH, dd, J 9.5, 2.5 Hz), 6.55 (IH, dd, J 16.5, 2.5 Hz).
Diphenylvinylsulfonium Triflate Preparation Products And Raw materials
Raw materials
Preparation Products
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