DDR1-IN-1
- Product Name
- DDR1-IN-1
- CAS No.
- 1449685-96-4
- Chemical Name
- DDR1-IN-1
- Synonyms
- TL4-44;CS-1427;DDR-IN-1;DDR1-IN-1;DDR1 inhibitor 1;Ddr1-In-1, 10 mM in DMSO;Discoidin Domain Receptor,inhibit,Ddr-1-In-1,Inhibitor,Ddr1 In 1,Ddr1In1;4-((4-ethylpiperazin-1-yl)methyl)-N-(4-methyl-3-((2-oxoindolin-5-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide;4-[(4-ethylpiperazin-1-yl)methyl]-N-{4-methyl-3-[(2-oxo-2,3-dihydro-1H-indol-5-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide;N-[3-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamide
- CBNumber
- CB92705081
- Molecular Formula
- C30H31F3N4O3
- Formula Weight
- 552.59
- MOL File
- 1449685-96-4.mol
DDR1-IN-1 Property
- storage temp.
- Store at -20°C
- solubility
- DMSO : 100 mg/mL (180.97 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
- form
- Powder
- color
- Light yellow to yellow
- InChIKey
- AOZPVMOOEJAZGK-UHFFFAOYSA-N
- SMILES
- CC(C=CC(NC(C1=CC(C(F)(F)F)=C(CN2CCN(CC)CC2)C=C1)=O)=C3)=C3OC4=CC(CC(N5)=O)=C5C=C4
Safety
- WGK Germany
- WGK 3
- Storage Class
- 11 - Combustible Solids
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H413May cause long lasting harmful effects to aquatic life
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML2274
- Product name
- DDR1-IN-1
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $111
- Updated
- 2026/04/30
- Product number
- SML2274
- Product name
- DDR1-IN-1
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $363
- Updated
- 2026/04/30
- Product number
- CS-2808
- Product name
- DDR1-IN-1
- Purity
- 98.20%
- Packaging
- 5mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- CS-2808
- Product name
- DDR1-IN-1
- Purity
- 98.20%
- Packaging
- 10mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- BD165965
- Product name
- DDR1-IN-1 dihydrochloride
- Packaging
- 10mg
- Price
- $145
- Updated
- 2021/12/16
DDR1-IN-1 Chemical Properties,Usage,Production
Uses
DDR1-IN-1 is a potent and selective DDR1 receptor tyrosine kinase inhibitor with an IC50 of 105 nM; 4-fold less potent for DDR2 (IC50 = 413 nM)[1].
Definition
ChEBI: DDR1-IN-1 is a secondary carboxamide resulting from the formal condensation of the carboxy group of 4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)benzoic acid with the amino group of 5-(5-amino-2-methylphenoxy)-1,3-dihydro-2H-indol-2-one. It is a potent inhibitor of discoidin domain receptor tyrosine kinase 1 and 2 (DDR1/2) with IC50 = 105 nM and 413 nM, respectively. It has a role as an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor. It is a N-alkylpiperazine, a member of benzamides, a member of (trifluoromethyl)benzenes, a secondary carboxamide, an aromatic ether and a member of oxindoles.
Biochem/physiol Actions
DDR1-IN-1 is a type II, subtype-selective discoidin domain receptor (DDR) tyrosine kinase inhibitor (DDR1/2 IC50 = 105 nM/413 nM) that effectively blocks collagen-induced DDR1 pY513 autophosphorylation in U2OS cells (EC50 = 86.76 nM) with excellent selectivity over a panel of >380 kinases. DDR1-IN-1 inhibits DDR2-mediated MT1-MMP activation in human rheumatoid synovial fibroblasts (RASF) upon collagen stimulation (IC50 < 2.5 μM) and enhances PI3K/mTOR inhibitor GSK2126458 antiproliferation efficacy in SNU-1040 colorectal cancer culture (123%, 70%, 50% of control, respectively, post 48-hr 250 nM DDR1-IN-1, 82.5 nM GSK2126458, or combined treatment). ent). ned treatment).
References
[1] Kim HG, et al. Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor. ACS Chem Biol. 2013 Oct 18;8(10):2145-50. DOI:10.1021/cb400430t
DDR1-IN-1 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from DDR1-IN-1 manufacturers
- Product
- DDR1-IN-1 1449685-96-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99.9%
- Supply Ability
- 100kg
- Release date
- 2019-12-26