DDR1-IN-1

Product Name: DDR1-IN-1
CAS No.: 1449685-96-4
Chemical Name: DDR1-IN-1
Synonyms: TL4-44;CS-1427;DDR-IN-1;DDR1-IN-1;DDR1 inhibitor 1;Discoidin Domain Receptor,inhibit,Ddr-1-In-1,Inhibitor,Ddr1 In 1,Ddr1In1;4-((4-ethylpiperazin-1-yl)methyl)-N-(4-methyl-3-((2-oxoindolin-5-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide;4-[(4-ethylpiperazin-1-yl)methyl]-N-{4-methyl-3-[(2-oxo-2,3-dihydro-1H-indol-5-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide;N-[3-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamide;Benzamide, N-[3-[(2,3-dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)-
CBNumber: CB92705081
Molecular Formula: C30H31F3N4O3
Formula Weight: 552.59
MOL File: 1449685-96-4.mol

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DDR1-IN-1 Property

storage temp.: Store at -20°C
solubility: DMSO : 100 mg/mL (180.97 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form: Powder

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2274
Product name: DDR1-IN-1
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $118
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2274
Product name: DDR1-IN-1
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $399
Updated: 2024/03/01

ChemScene

Product number: CS-2808
Product name: DDR1-IN-1
Purity: 98.20%
Packaging: 5mg
Price: $90
Updated: 2021/12/16

ChemScene

Product number: CS-2808
Product name: DDR1-IN-1
Purity: 98.20%
Packaging: 10mg
Price: $140
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BD165965
Product name: DDR1-IN-1 dihydrochloride
Packaging: 10mg
Price: $145
Updated: 2021/12/16

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DDR1-IN-1 Chemical Properties,Usage,Production

Definition

ChEBI: DDR1-IN-1 is a secondary carboxamide resulting from the formal condensation of the carboxy group of 4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)benzoic acid with the amino group of 5-(5-amino-2-methylphenoxy)-1,3-dihydro-2H-indol-2-one. It is a potent inhibitor of discoidin domain receptor tyrosine kinase 1 and 2 (DDR1/2) with IC50 = 105 nM and 413 nM, respectively. It has a role as an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor. It is a N-alkylpiperazine, a member of benzamides, a member of (trifluoromethyl)benzenes, a secondary carboxamide, an aromatic ether and a member of oxindoles.

Biochem/physiol Actions

DDR1-IN-1 is a type II, subtype-selective discoidin domain receptor (DDR) tyrosine kinase inhibitor (DDR1/2 IC50 = 105 nM/413 nM) that effectively blocks collagen-induced DDR1 pY513 autophosphorylation in U2OS cells (EC50 = 86.76 nM) with excellent selectivity over a panel of >380 kinases. DDR1-IN-1 inhibits DDR2-mediated MT1-MMP activation in human rheumatoid synovial fibroblasts (RASF) upon collagen stimulation (IC50 < 2.5 μM) and enhances PI3K/mTOR inhibitor GSK2126458 antiproliferation efficacy in SNU-1040 colorectal cancer culture (123%, 70%, 50% of control, respectively, post 48-hr 250 nM DDR1-IN-1, 82.5 nM GSK2126458, or combined treatment). ent). ned treatment).

DDR1-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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DDR1-IN-1 Suppliers

China 54 The Netherlands 1 United States 11 Global 66

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2923
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Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.

Tel: 21-57721279
Fax: QQ：14057904
Email: sales@shydchem.com.cn
Country: China
ProdList: 982
Advantage: 56

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7553
Advantage: 61

Acesys Pharmatech

Tel: 18860950986
Email: tangmanman@zenjipharma.com
Country: China
ProdList: 1735
Advantage: 55

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4863
Advantage: 58

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2784
Advantage: 58

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4121
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ShangHai Siyan Biological Technology Co., Ltd.

Tel: 021-50908862，442785678，326799392 18721037013
Fax: 021-50908862
Email: siyansales@126.com
Country: China
ProdList: 9638
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9709
Advantage: 58

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View Lastest Price from DDR1-IN-1 manufacturers

Career Henan Chemical Co

Product: DDR1-IN-1 1449685-96-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 100kg
Release date: 2019-12-26

1449685-96-4, DDR1-IN-1Related Search:

TL4-44

DDR-IN-1

DDR1-IN-1

N-[3-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamide

4-((4-ethylpiperazin-1-yl)methyl)-N-(4-methyl-3-((2-oxoindolin-5-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide

CS-1427

DDR1 inhibitor 1

Benzamide, N-[3-[(2,3-dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)-

Discoidin Domain Receptor,inhibit,Ddr-1-In-1,Inhibitor,Ddr1 In 1,Ddr1In1

4-[(4-ethylpiperazin-1-yl)methyl]-N-{4-methyl-3-[(2-oxo-2,3-dihydro-1H-indol-5-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide

1449685-96-4

C30H31F3N4O3