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DDR1-IN-1

Product Name
DDR1-IN-1
CAS No.
1449685-96-4
Chemical Name
DDR1-IN-1
Synonyms
TL4-44;CS-1427;DDR-IN-1;DDR1-IN-1;DDR1 inhibitor 1;Discoidin Domain Receptor,inhibit,Ddr-1-In-1,Inhibitor,Ddr1 In 1,Ddr1In1;4-((4-ethylpiperazin-1-yl)methyl)-N-(4-methyl-3-((2-oxoindolin-5-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide;4-[(4-ethylpiperazin-1-yl)methyl]-N-{4-methyl-3-[(2-oxo-2,3-dihydro-1H-indol-5-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide;N-[3-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamide;Benzamide, N-[3-[(2,3-dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)-
CBNumber
CB92705081
Molecular Formula
C30H31F3N4O3
Formula Weight
552.59
MOL File
1449685-96-4.mol
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DDR1-IN-1 Property

storage temp. 
Store at -20°C
solubility 
DMSO : 100 mg/mL (180.97 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form 
Powder
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2274
Product name
DDR1-IN-1
Purity
≥98% (HPLC)
Packaging
5mg
Price
$118
Updated
2024/03/01
Sigma-Aldrich
Product number
SML2274
Product name
DDR1-IN-1
Purity
≥98% (HPLC)
Packaging
25mg
Price
$399
Updated
2024/03/01
ChemScene
Product number
CS-2808
Product name
DDR1-IN-1
Purity
98.20%
Packaging
5mg
Price
$90
Updated
2021/12/16
ChemScene
Product number
CS-2808
Product name
DDR1-IN-1
Purity
98.20%
Packaging
10mg
Price
$140
Updated
2021/12/16
Biosynth Carbosynth
Product number
BD165965
Product name
DDR1-IN-1 dihydrochloride
Packaging
10mg
Price
$145
Updated
2021/12/16
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DDR1-IN-1 Chemical Properties,Usage,Production

Definition

ChEBI: DDR1-IN-1 is a secondary carboxamide resulting from the formal condensation of the carboxy group of 4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)benzoic acid with the amino group of 5-(5-amino-2-methylphenoxy)-1,3-dihydro-2H-indol-2-one. It is a potent inhibitor of discoidin domain receptor tyrosine kinase 1 and 2 (DDR1/2) with IC50 = 105 nM and 413 nM, respectively. It has a role as an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor. It is a N-alkylpiperazine, a member of benzamides, a member of (trifluoromethyl)benzenes, a secondary carboxamide, an aromatic ether and a member of oxindoles.

Biochem/physiol Actions

DDR1-IN-1 is a type II, subtype-selective discoidin domain receptor (DDR) tyrosine kinase inhibitor (DDR1/2 IC50 = 105 nM/413 nM) that effectively blocks collagen-induced DDR1 pY513 autophosphorylation in U2OS cells (EC50 = 86.76 nM) with excellent selectivity over a panel of >380 kinases. DDR1-IN-1 inhibits DDR2-mediated MT1-MMP activation in human rheumatoid synovial fibroblasts (RASF) upon collagen stimulation (IC50 < 2.5 μM) and enhances PI3K/mTOR inhibitor GSK2126458 antiproliferation efficacy in SNU-1040 colorectal cancer culture (123%, 70%, 50% of control, respectively, post 48-hr 250 nM DDR1-IN-1, 82.5 nM GSK2126458, or combined treatment). ent). ned treatment).

DDR1-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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DDR1-IN-1 Suppliers

Axon Medchem BV
Tel
--
Fax
--
Email
info@axonmedchem.com
Country
The Netherlands
ProdList
477
Advantage
30
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View Lastest Price from DDR1-IN-1 manufacturers

Career Henan Chemical Co
Product
DDR1-IN-1 1449685-96-4
Price
US $1.00/KG
Min. Order
1KG
Purity
97%-99.9%
Supply Ability
100kg
Release date
2019-12-26

1449685-96-4, DDR1-IN-1Related Search:


  • TL4-44
  • DDR-IN-1
  • DDR1-IN-1
  • N-[3-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamide
  • 4-((4-ethylpiperazin-1-yl)methyl)-N-(4-methyl-3-((2-oxoindolin-5-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide
  • CS-1427
  • DDR1 inhibitor 1
  • Benzamide, N-[3-[(2,3-dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)-
  • Discoidin Domain Receptor,inhibit,Ddr-1-In-1,Inhibitor,Ddr1 In 1,Ddr1In1
  • 4-[(4-ethylpiperazin-1-yl)methyl]-N-{4-methyl-3-[(2-oxo-2,3-dihydro-1H-indol-5-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide
  • 1449685-96-4
  • C30H31F3N4O3