6,7-Difluoro-1H-indazole
- Product Name
- 6,7-Difluoro-1H-indazole
- CAS No.
- 1260384-41-5
- Chemical Name
- 6,7-Difluoro-1H-indazole
- Synonyms
- 6,7-Difluoro-1H-indazole;1H-Indazole, 6,7-difluoro-
- CBNumber
- CB92714052
- Molecular Formula
- C7H4F2N2
- Formula Weight
- 154.12
- MOL File
- 1260384-41-5.mol
6,7-Difluoro-1H-indazole Property
- storage temp.
- Sealed in dry,Room Temperature
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D454085
- Product name
- 6,7-Difluoro-1H-indazole
- Packaging
- 500mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- 3H31-3-6J
- Product name
- 6,7-Difluoro-1H-indazole
- Purity
- 97%
- Packaging
- 1g
- Price
- $488
- Updated
- 2021/12/16
- Product number
- 9475DX
- Product name
- 6,7-Difluoro-1H-indazole
- Packaging
- 10g
- Price
- $726
- Updated
- 2021/12/16
- Product number
- PC201098
- Product name
- 6,7-Difluoro-1H-indazole
- Purity
- 97%
- Packaging
- 100mg
- Price
- $77
- Updated
- 2021/12/16
- Product number
- 9475DX
- Product name
- 6,7-Difluoro-1H-indazole
- Packaging
- 250mg
- Price
- $111
- Updated
- 2021/12/16
6,7-Difluoro-1H-indazole Chemical Properties,Usage,Production
Synthesis
161793-17-5
1260384-41-5
The general procedure for the synthesis of 6,7-difluoro-1H-indazole from 2,3,4-trifluorobenzaldehyde was as follows: 2,3,4-trifluorobenzaldehyde (1.5 g, 9.4 mmol) was dissolved in 1,4-dioxane (6 mL) in a microwave reaction flask. Hydrazine (6 mL, 191 mmol) was then added. The reaction vial was sealed and heated at 150°C for 30 min under microwave radiation. Upon completion of the reaction, the reaction was quenched with water and extracted with ethyl acetate (EtOAc). The organic layer was washed with brine, dried over anhydrous magnesium sulfate (MgSO4) and concentrated. The residue was purified by silica gel column chromatography using 20% to 50% ethyl acetate/heptane as eluent to afford 664 mg (46% yield) of 6,7-difluoro-1H-indazole as a light brown powder.1H NMR (CDCl3, 300 MHz) data were as follows: δ (ppm) 8.10 (d, J = 3.4 Hz, 1H), 7.47 ( dd, J = 8.9, 4.0 Hz, 1H), 7.05 (ddd, J = 10.6, 8.9, 6.6 Hz, 1H).
References
[1] Patent: WO2013/30138, 2013, A1. Location in patent: Page/Page column 234; 235
6,7-Difluoro-1H-indazole Preparation Products And Raw materials
Raw materials
Preparation Products
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