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CASIN

Product Name
CASIN
CAS No.
425399-05-9
Chemical Name
CASIN
Synonyms
CASIN;Casin, >98%;CASIN >=98% (HPLC);Pirl1-related Compound 2;2-(6-phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-ylamino)ethanol;2-[(2,3,4,9-Tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]ethanol;Ethanol, 2-[(2,3,4,9-tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]-;2-((6-Phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)amino)ethan-1-ol;Chemical Intermediate Safe Delivery Manufacturer Supply CAS 9000-71-9 Casein;Ras,multiple myeloma,drug resistance,inhibit,Apoptosis,Inhibitor,CASIN,bortezomib
CBNumber
CB92714663
Molecular Formula
C20H22N2O
Formula Weight
306.4
MOL File
425399-05-9.mol
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CASIN Property

Boiling point:
577.8±50.0 °C(Predicted)
Density 
1.23±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
≥30.6 mg/mL in DMSO; insoluble in H2O; ≥19.5 mg/mL in EtOH
form 
powder
pka
14.76±0.10(Predicted)
color 
white to very dark brown
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1253
Product name
CASIN
Purity
≥98% (HPLC)
Packaging
5MG
Price
$115
Updated
2023/06/20
Sigma-Aldrich
Product number
SML1253
Product name
CASIN
Purity
≥98% (HPLC)
Packaging
25MG
Price
$451
Updated
2023/06/20
Cayman Chemical
Product number
17694
Product name
CASIN
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
17694
Product name
CASIN
Purity
≥95%
Packaging
5mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
17694
Product name
CASIN
Purity
≥95%
Packaging
10mg
Price
$199
Updated
2024/03/01
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CASIN Chemical Properties,Usage,Production

Description

The Rho family of GTPases regulates diverse signal transduction pathways. One member, the cell division control protein 42 homolog (Cdc42), is involved in filopodia function, cell polarity, cell cycling, and other processes. CASIN is an indole-based small molecule that inhibits activation of the Cdc42 GTPase (IC50 = 2 μM for inhibiting actin assembly in PIP2-stimulated actin polymerization assays). This compound has been used to explore the role of Cdc42 in the division, survival, and differentiation of hematopoietic stem cells.

Uses

CASIN has been used as a cell division control protein 42 homolog (Cdc42) inhibitor:

  • to study its effects on the stimulation of extracellular vesicles (EVs) in intestinal epithelial cells
  • to study its effects on mice jejunum
  • to study its effects on microbial adhesion-triggered endocytosis (MATE) vesicle morphology in segmented filamentous bacteria (SFB)-colonized mice

Biochem/physiol Actions

CASIN is an inhibitor of Cdc42 GTPase, a small GTPase of the Rho-subfamily that plays important roles in cytoskeleton organization, cell cycle progression, signal transduction, and vesicle trafficking. CASIN generated a rejuvenated phenotype of Hematopoietic stem cells (HSCs), reversing the aging-related and polarity phenotype of aged HSCs to that of young HSCs in vivo..

in vitro

previous study found that treatment with casin at 5μm reduced the elevated level of active cdc42 observed in aged primitive hematopoietic cells to the level observed in young cells. however, casin treatment could not alter cell cycle status or apoptosis in aged lt-hscs. moreover, in response to the treatment of casin, lt-hscs from aged mice had a dose-dependent increase in the percentage of polarized cells, which is progressively indistinguishable from young cells. in addition, though casin acted on cdc42 activity transiently, the increase in the percentage of polar cells among aged lt-hscs that were induced by casin could remain stable for at least up to 6 hr after the withdrawal of casin [1].

in vivo

rat in-vivo study showed that casin could generated a rejuvenated phenotype of hematopoietic stem cells (hscs), reversing the aging-related and polarity phenotype of aged hscs to that of young hscs [1].

IC 50

2 μm

storage

Store at -20°C

References

[1] florian mc,drr k,niebel a,daria d,schrezenmeier h,rojewski m,filippi md,hasenberg a,gunzer m,scharffetter-kochanek k,zheng y,geiger h. cdc42 activity regulates hematopoietic stem cell aging and rejuvenation. cell stem cell.2012 may 4;10(5):520-30.

CASIN Preparation Products And Raw materials

Raw materials

Preparation Products

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425399-05-9, CASINRelated Search:


  • CASIN
  • 2-(6-phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-ylamino)ethanol
  • 2-[(2,3,4,9-Tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]ethanol
  • Casin, >98%
  • Pirl1-related Compound 2
  • Ethanol, 2-[(2,3,4,9-tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]-
  • CASIN >=98% (HPLC)
  • Chemical Intermediate Safe Delivery Manufacturer Supply CAS 9000-71-9 Casein
  • 2-((6-Phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)amino)ethan-1-ol
  • Ras,multiple myeloma,drug resistance,inhibit,Apoptosis,Inhibitor,CASIN,bortezomib
  • 425399-05-9