ChemicalBook > CAS DataBase List > Eravacycline

Eravacycline

Product Name
Eravacycline
CAS No.
1207283-85-9
Chemical Name
Eravacycline
Synonyms
Eravacycline;(4S,12aS)-4-(dimethylamino)-7-fluoro-3,10,12,12a-tetrahydroxy-1,11-dioxo-9-(2-(pyrrolidin-1-yl)acetamido)-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide;TP-434;Eravacyclin;(Eravacvcline);Eravacycline TP-434;TP-434(Eravacycline);TP-434 dihydrochloride;Tigecycline Impurity 39;ERAVACYCLINE; TP434; TP 434
CBNumber
CB92714678
Molecular Formula
C27H31FN4O8
Formula Weight
558.56
MOL File
1207283-85-9.mol
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Eravacycline Property

Boiling point:
868.1±65.0 °C(Predicted)
Density 
1.60±0.1 g/cm3(Predicted)
storage temp. 
Amber Vial, -20°C Freezer, Under inert atmosphere
pka
4.50±1.00(Predicted)
Water Solubility 
Water : 50 mg/mL (79.18 mM)
InChIKey
HLFSMUUOKPBTSM-ISIOAQNYSA-N
SMILES
N1(CC(NC2=CC(F)=C3C(=C2O)C(=O)C2[C@]([H])(C[C@]4([H])[C@](O)(C=2O)C(=O)C(C(N)=O)=C(O)[C@H]4N(C)C)C3)=O)CCCC1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P322Specific measures (see …on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
24059
Product name
TP-434
Purity
≥95% (mixture of tautomers)
Packaging
1mg
Price
$25
Updated
2021/12/16
Cayman Chemical
Product number
24059
Product name
TP-434
Purity
≥95% (mixture of tautomers)
Packaging
5mg
Price
$113
Updated
2021/12/16
Cayman Chemical
Product number
24059
Product name
TP-434
Purity
≥95% (mixture of tautomers)
Packaging
10mg
Price
$200
Updated
2021/12/16
Cayman Chemical
Product number
24059
Product name
TP-434
Purity
≥95% (mixture of tautomers)
Packaging
25mg
Price
$438
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
46024
Product name
Eravacycline
Packaging
1mg
Price
$750
Updated
2021/12/16
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Eravacycline Chemical Properties,Usage,Production

Uses

Eravacyclineis a synthetic fluorocycline antibiotic.

Definition

ChEBI: Eravacycline is a member of tetracyclines.

in vivo

Mice are treated with two-fold increasing doses (range 3.125 to 50 mg/kg) of eravacycline every 12 hours. The mean fAUC/MIC magnitude associated with net stasis and 1-log kill endpoint are 27.97±8.29 and 32.60±10.85, respectively[2]. Eravacycline is active in multiple murine models of infection against clinically important Gram-positive and Gram-negative pathogens. Eravacycline is efficacious in mouse septicemia models, demonstrating 50% protective dose values of ≤1 mg/kg of body weight once a day (q.d.) against Staphylococcus aureus, including tetracycline-resistant isolates of methicillin-resistant S. aureus (MRSA), and Streptococcus pyogenes. The PD50 values against Escherichia coli isolates are 1.2 to 4.4 mg/kg q.d[5].

IC 50

Tetracycline

Eravacycline Preparation Products And Raw materials

Raw materials

Preparation Products

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Eravacycline Suppliers

China 69 India 2 United States 5 Global 76
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View Lastest Price from Eravacycline manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Eravacycline 1207283-85-9
Price
US $0.00/mg
Min. Order
10mg
Purity
0.98
Supply Ability
5g
Release date
2025-03-21
Hebei Yanxi Chemical Co., Ltd.
Product
TP-434 1207283-85-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100tons
Release date
2023-08-16
Shaanxi Dideu Medichem Co. Ltd
Product
Eravacycline 1207283-85-9
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000Tons
Release date
2024-08-04

1207283-85-9, EravacyclineRelated Search:


  • TP-434
  • TP-434(Eravacycline)
  • ERAVACYCLINE; TP434; TP 434
  • 4-Dimethylamino-7-fluoro-3,10,12,12a-tetrahydroxy-1,11-dioxo-9-(2-pyrrolidin-1-yl-cetylamino)-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide (ERAVACYCLINE)
  • Eravacycline
  • (4S,12aS)-4-(dimethylamino)-7-fluoro-3,10,12,12a-tetrahydroxy-1,11-dioxo-9-(2-(pyrrolidin-1-yl)acetamido)-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
  • 1-Pyrrolidineacetamide, N-[(5aR,6aS,7S,10aS)-9-(aminocarbonyl)-7-(dimethylamino)-4-fluoro-5,5a,6,6a,7,10,10a,12-octahydro-1,8,10a,11-tetrahydroxy-10,12-dioxo-2-naphthacenyl]-
  • Eravacycline TP-434
  • (4S,4aS,5aR,12aR)-4-(dimethylamino)-7-fluoro-1,10,11,12a-tetrahydroxy-3,12-dioxo-9-[(2-pyrrolidin-1-ylacetyl)amino]-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide
  • TP-434 dihydrochloride
  • Tigecycline Impurity 39
  • Eravacyclin
  • 7-fluoro-9-pyrrolidinoacetamido-6-demethyl-6-deoxytetracycline
  • (Eravacvcline)
  • (4S,4aS,5aR,12aS)-4-(dimethylamino)-7-fluoro-3,10,12,12a-tetrahydroxy-1,11-dioxo-9-(2-(pyrrolidin-1-yl)acetamido)-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
  • 1207283-85-9
  • C27H31FN4O8