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CP-640186 (hydrochloride)

Product Name
CP-640186 (hydrochloride)
CAS No.
591778-70-0
Chemical Name
CP-640186 (hydrochloride)
Synonyms
CS-1253;CP640186 HCl;CP-640186 (hydrochloride);CP-640186 hydrochloride, >=98%;CP-640186 hydrochloride, 10 mM in DMSO;(3R)-1'-(anthracene-9-carbonyl)-3-(morpholine-4-c arbonyl)-1,4'-bipiperidine hydrochloride;(R)-Anthracen-9-yl(3-(morpholine-4-carbonyl)-[1,4'-bipiperidin]-1'-yl)methanone hydrochloride;HepG2,muscle fatty acid oxidation,Inhibitor,CP 640186,CP640186,C2C12,CP-640186,human fibroblasts,H460,muscle strips,CP 640186 hydrochloride,inhibit,ACC, Acetyl Coenzyme A Carboxylase,Acetyl-CoA Carboxylase,CP640186 hydrochloride
CBNumber
CB92715620
Molecular Formula
C30H36ClN3O3
Formula Weight
522.09
MOL File
591778-70-0.mol
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CP-640186 (hydrochloride) Property

storage temp. 
Store at -20°C
solubility 
DMSO:39.0(Max Conc. mg/mL);74.7(Max Conc. mM)
H2O:50.0(Max Conc. mg/mL);95.77(Max Conc. mM)
form 
Solid
color 
Light yellow to pink
Water Solubility 
H2O: 2mg/mL, clear (warmed)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PZ0362
Product name
CP-640186 hydrochloride
Purity
≥95% (HPLC)
Packaging
5 mg
Price
$108
Updated
2025/07/31
Sigma-Aldrich
Product number
PZ0362
Product name
CP-640186 hydrochloride
Purity
≥95% (HPLC)
Packaging
25 mg
Price
$436
Updated
2025/07/31
ChemScene
Product number
CS-3135
Product name
CP-640186hydrochloride
Purity
99.81%
Packaging
50mg
Price
$660
Updated
2021/12/16
ChemScene
Product number
CS-3135
Product name
CP-640186hydrochloride
Purity
99.81%
Packaging
100mg
Price
$900
Updated
2021/12/16
ChemScene
Product number
CS-3135
Product name
CP-640186hydrochloride
Purity
99.81%
Packaging
5mg
Price
$120
Updated
2021/12/16
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CP-640186 (hydrochloride) Chemical Properties,Usage,Production

Uses

CP 640186 Hydrochloride can be used as acetyl CoA carboxylase inhibitors against metabolic syndrome and other disorders.

Biological Activity

CP-640186 is a potent and orally active acetyl-CoA carboxylase 1/2 (ACC-alpha/beta, ACC1/2) inhibitor (IC50 ~50 nM) th at targets the carboxyltransferase (CT) domain at the ACC dimer interface (via tight interactions with the putative biotin-binding site) in a reversible manner, uncompetitive with respect to ATP, and non-competitive with respect to bicarbonate, acetyl-CoA, and citrate. CP-610431 inhibits fatty acid (FA) synthesis, triglyceride (TG) synthesis, TG and apoB secretion (IC50 = 1.6, 1.8, 3.0, and 5.7 μM, respectively), but not cholesterol synthesis or apoC3 secretion in HepG2 cells (ACC1), as well as stimulates FA oxidation in C2C12 cells (ACC2) and in r at epitrochlearis muscle strips (EC50 = 57 nM and 1.3 μM, respectively). Oral administration is shown to inhibit FA synthesis in rats, CD1 mice, and ob/ob mice (ED50 = 13, 11, and 4 mg/kg, respectively) and stimulate r at whole body FA oxidation (ED50 ∼30 mg/kg) in vivo.

in vivo

CP-640186 (oral gavage; 4.6-21 mg/kg; once) demonstrates acute efficacy[1].
CP-640186 (intravenous injection and oral gavage; Intravenous dose, 5 mg/kg; oral dose, 10 mg/kg; once) shows lowe drug exposure in the rat than the ob/ob mouse at equal doses[1].
CP-640186 (oral gavage; 100 mg/kg; once) treatment shows a complete shift from carbohydrate utilization to fatty acid utilization as a source of energy at high exposure level[1].

Animal Model:Male ob/ob mice[1]
Dosage:4.6-21 mg/kg
Administration:Oral gavage; 4.6-21 mg/kg; once
Result:Demonstrated acute efficacy for up to 8 h after oral administration, exhibiting ED50 values of 4.6, 9.7, and 21 mg/kg, at 1, 4, and 8 h, respectively, after treatment.
Animal Model:Male Sprague-Dawley rats[1]
Dosage:Intravenous dose, 5 mg/kg; oral dose, 10 mg/kg
Administration:Intravenous injection and oral gavage; intravenous dose, 5 mg/kg; oral dose, 10 mg/kg; once
Result:Showed a plasma half-life of 1.5 h, a bioavailability of 39%, a Clp of 65 ml/min/kg, a Vdss of 5 liters/kg, an oral Tmax of 1.0 h, an oral Cmax of 345 ng/mL, and an oral AUC0-∞ of 960 ng?h/mL.
Animal Model:Male ob/ob mice[1]
Dosage:Intravenous dose, 5 mg/kg; oral dose, 10 mg/kg
Administration:Intravenous injection and oral gavage; Intravenous dose, 5 mg/kg; oral dose, 10 mg/kg; once
Result:Showed a plasma half-life of 1.1 h, a bioavailability of 50%, a Clp of 54 ml/min/kg, an oral Tmax of 0.25 h, an oral Cmax of 2177 ng/mL, and an oral AUC0-∞ of 3068 ng?h/mL.
Animal Model:Twenty male Sprague-Dawley rats (350-400 g) fasted and then refed a high sucrose diet for 2 days; additional eight rats fasted for 24 h[1]
Dosage:100 mg/kg
Administration:Oral gavage; 100 mg/kg; once
Result:Resulted in time-dependent reductions in RQ (a ratio of CO2 production to O2 consumption) of up to 64%.

CP-640186 (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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CP-640186 (hydrochloride) Suppliers

China 59 India 1 United States 7 Global 67
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
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7552
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MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
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58
SPIRO PHARMA
Tel
Fax
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Email
eric_feng1954@126.com
Country
China
ProdList
9248
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55
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
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3866
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58
Lancrix Chemicals
Tel
86-21-50817262
Fax
86-21-57712035
Email
sales@lancrix.com
Country
China
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ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
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China
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8000
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Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136
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21-5161 9052
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Sales@ATKchemical.com
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China
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Amadis Chemical Company Limited
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571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
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131957
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Musechem
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+1-800-259-7612
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+1-800-259-7612
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info@musechem.com
Country
United States
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Angel Pharmatech, Ltd.
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17317130613
Fax
QQ3358272972
Email
3358272972@qq.com
Country
China
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591778-70-0, CP-640186 (hydrochloride)Related Search:

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