CP-640186 (hydrochloride)

Product Name: CP-640186 (hydrochloride)
CAS No.: 591778-70-0
Chemical Name: CP-640186 (hydrochloride)
Synonyms: CS-1253;CP640186 HCl;CP-640186 (hydrochloride);CP-640186 hydrochloride, >=98%;CP-640186 hydrochloride, 10 mM in DMSO;(3R)-1'-(anthracene-9-carbonyl)-3-(morpholine-4-c arbonyl)-1,4'-bipiperidine hydrochloride;(R)-Anthracen-9-yl(3-(morpholine-4-carbonyl)-[1,4'-bipiperidin]-1'-yl)methanone hydrochloride;HepG2,muscle fatty acid oxidation,Inhibitor,CP 640186,CP640186,C2C12,CP-640186,human fibroblasts,H460,muscle strips,CP 640186 hydrochloride,inhibit,ACC, Acetyl Coenzyme A Carboxylase,Acetyl-CoA Carboxylase,CP640186 hydrochloride
CBNumber: CB92715620
Molecular Formula: C30H36ClN3O3
Formula Weight: 522.09
MOL File: 591778-70-0.mol

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CP-640186 (hydrochloride) Property

storage temp.: Store at -20°C
solubility: DMSO:39.0(Max Conc. mg/mL);74.7(Max Conc. mM)
H2O:50.0(Max Conc. mg/mL);95.77(Max Conc. mM)
form: Solid
color: Light yellow to pink
Water Solubility: H2O: 2mg/mL, clear (warmed)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-3135
Product name: CP-640186hydrochloride
Purity: 99.81%
Packaging: 5mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-3135
Product name: CP-640186hydrochloride
Purity: 99.81%
Packaging: 10mg
Price: $192
Updated: 2021/12/16

ChemScene

Product number: CS-3135
Product name: CP-640186hydrochloride
Purity: 99.81%
Packaging: 50mg
Price: $660
Updated: 2021/12/16

ChemScene

Product number: CS-3135
Product name: CP-640186hydrochloride
Purity: 99.81%
Packaging: 100mg
Price: $900
Updated: 2021/12/16

DC Chemicals

Product number: DC9265
Product name: CP-640186hydrochloride
Purity: >98%
Packaging: 1g
Price: $2500
Updated: 2021/12/16

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CP-640186 (hydrochloride) Chemical Properties,Usage,Production

Uses

CP 640186 Hydrochloride can be used as acetyl CoA carboxylase inhibitors against metabolic syndrome and other disorders.

Biological Activity

CP-640186 is a potent and orally active acetyl-CoA carboxylase 1/2 (ACC-alpha/beta, ACC1/2) inhibitor (IC50 ~50 nM) th at targets the carboxyltransferase (CT) domain at the ACC dimer interface (via tight interactions with the putative biotin-binding site) in a reversible manner, uncompetitive with respect to ATP, and non-competitive with respect to bicarbonate, acetyl-CoA, and citrate. CP-610431 inhibits fatty acid (FA) synthesis, triglyceride (TG) synthesis, TG and apoB secretion (IC50 = 1.6, 1.8, 3.0, and 5.7 μM, respectively), but not cholesterol synthesis or apoC3 secretion in HepG2 cells (ACC1), as well as stimulates FA oxidation in C2C12 cells (ACC2) and in r at epitrochlearis muscle strips (EC50 = 57 nM and 1.3 μM, respectively). Oral administration is shown to inhibit FA synthesis in rats, CD1 mice, and ob/ob mice (ED50 = 13, 11, and 4 mg/kg, respectively) and stimulate r at whole body FA oxidation (ED50 ∼30 mg/kg) in vivo.

CP-640186 (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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CP-640186 (hydrochloride) Suppliers

China 58 India 1 United States 7 Global 66

Haoyuan Chemexpress Co., Ltd.

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Angel Pharmatech, Ltd.

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591778-70-0, CP-640186 (hydrochloride)Related Search:

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CP-640186 (hydrochloride)

CP640186 HCl

CP-640186 hydrochloride, >=98%

CS-1253

(3R)-1'-(anthracene-9-carbonyl)-3-(morpholine-4-c arbonyl)-1,4'-bipiperidine hydrochloride

HepG2,muscle fatty acid oxidation,Inhibitor,CP 640186,CP640186,C2C12,CP-640186,human fibroblasts,H460,muscle strips,CP 640186 hydrochloride,inhibit,ACC, Acetyl Coenzyme A Carboxylase,Acetyl-CoA Carboxylase,CP640186 hydrochloride

(R)-Anthracen-9-yl(3-(morpholine-4-carbonyl)-[1,4'-bipiperidin]-1'-yl)methanone hydrochloride

CP-640186 hydrochloride, 10 mM in DMSO

591778-70-0

C30H35N3O3ClH