ChemicalBook > CAS DataBase List > CDN 1163

CDN 1163

Product Name: CDN 1163
CAS No.: 892711-75-0
Chemical Name: CDN 1163
Synonyms: CDN1163;CDN1163, 10 mM in DMSO;4-isopropoxy-N-(2-methylquinolin-8-yl)benzamide;N-(2-methylquinolin-8-yl)-4-propan-2-yloxybenzamide;4-(1-Methylethoxy)-N-(2-methyl-8-quinolinyl)benzamide;Benzamide, 4-(1-methylethoxy)-N-(2-methyl-8-quinolinyl)-;Inhibitor,CDN 1163,Calcium Channel,Ca channels,Ca2+ channels,CDN-1163,CDN1163,inhibit
CBNumber: CB92722925
Molecular Formula: C20H20N2O2
Formula Weight: 320.39
MOL File: 892711-75-0.mol

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CDN 1163 Property

Melting point:: 87 - 89°C
storage temp.: 2-8°C
solubility: Soluble in DMSO (>25 mg/ml)
form: powder
color: white to beige
Stability:: Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1682
Product name: CDN1163
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $104.01
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1682
Product name: CDN1163
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $312.9
Updated: 2025/07/31

Tocris

Product number: 5869
Product name: CDN1163
Purity: ≥98%(HPLC)
Packaging: 10
Price: $162
Updated: 2021/12/16

Tocris

Product number: 5869
Product name: CDN1163
Purity: ≥98%(HPLC)
Packaging: 50
Price: $670
Updated: 2021/12/16

TRC

Product number: M258730
Product name: 4-(1-Methylethoxy)-N-(2-methyl-8-quinolinyl)benzamide
Packaging: 25mg
Price: $460
Updated: 2021/12/16

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CDN 1163 Chemical Properties,Usage,Production

Description

CDN1163 (892711-75-0) is an allosteric activator of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA).1,2? It lowered fasting glucose levels, improved glucose tolerance, and ameliorated hepatitis steatosis in ob/ob mice.1?? CDN1163 also rescued neurons from ER-stress-induced cell death in vitro and displayed significant efficacy in a rat 6-hydroxydopamine (6-OHDA) model of Parkinson’s disease.2 It reduced age-related muscle atrophy and weakness in a C57BL/6J mice.3? CDN1163 decreased inflammatory cytokines and chemokines and attenuated mitochondrial dysfunction in Influenza A infected H1395 cells.4

Uses

4-(1-Methylethoxy)-N-(2-methyl-8-quinolinyl)benzamide is an allosteric activator that increases Ca2+-ATPase activity and Ca2+ uptake by ER microsomes. 4-(1-Methylethoxy)-N-(2-methyl-8-quinolinyl)benzamide may have therapeutic potential for treating type-2 diabetes and metabolic dysfunction.

Definition

ChEBI: CDN1163 is a secondary carboxamide resulting from the formal condensation of the carboxy group of 4-isopropoxybenzoic acid with the primary amino group of 2-methylquinolin-8-amine. An allosteric activator of sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA). It has a role as a SERCA activator. It is a member of quinolines, a secondary carboxamide and an aromatic ether.

Biochem/physiol Actions

CDN1163 is an allosteric activator of sarco/ endoplasmic reticulum Ca2+-ATPase (SERCA) that potently lowered fasting blood glucose, improved glucose tolerance and ameliorated hepatosteatosis in ob/ob mice. Additionally CDN1163 induces significant reduction in adipose tissue weight with no change in lean mass in ob/ob mice. CDN1163 has no effect on glucose levels or body weight in lean control mice.

storage

Store at RT

References

[1] SOOJEONG KANG. Small Molecular Allosteric Activator of the Sarco/Endoplasmic Reticulum Ca2+-ATPase (SERCA) Attenuates Diabetes and Metabolic Disorders.[J]. The Journal of Biological Chemistry, 2016, 291 10: 5185-5198. DOI:10.1074/jbc.m115.705012
[2] DAHL R. A new target for Parkinson’s disease: Small molecule SERCA activator CDN1163 ameliorates dyskinesia in 6-OHDA-lesioned rats[J]. Bioorganic & Medicinal Chemistry, 2017, 25 1: Pages 53-57. DOI:10.1016/j.bmc.2016.10.008
[3] RIZWAN QAISAR. Restoration of Sarcoplasmic Reticulum Ca2+ ATPase (SERCA) Activity Prevents Age-Related Muscle Atrophy and Weakness in Mice.[J]. International Journal of Molecular Sciences, 2020, 22 1. DOI:10.3390/ijms22010037
[4] JIAOJIAO PENG. Sarco/Endoplasmic Reticulum Ca2+ Transporting ATPase (SERCA) Modulates Autophagic, Inflammatory, and Mitochondrial Responses during Influenza A Virus Infection in Human Lung Cells.[J]. Journal of Virology, 2021, 95 10. DOI:10.1128/jvi.00217-21

CDN 1163 Preparation Products And Raw materials

Raw materials

Preparation Products

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892711-75-0, CDN 1163Related Search:

RESINIFERATOXIN N-Eicosanoyl Serotonin METHOPRENE ACID N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate (1:1)

N-(2-methylquinolin-8-yl)-4-propan-2-yloxybenzamide

4-(1-Methylethoxy)-N-(2-methyl-8-quinolinyl)benzamide

4-isopropoxy-N-(2-methylquinolin-8-yl)benzamide

CDN1163

Benzamide, 4-(1-methylethoxy)-N-(2-methyl-8-quinolinyl)-

Inhibitor,CDN 1163,Calcium Channel,Ca channels,Ca2+ channels,CDN-1163,CDN1163,inhibit

CDN1163, 10 mM in DMSO

892711-75-0