2,2-Difluoro-1,3-benzodioxol-5-ol

Product Name: 2,2-Difluoro-1,3-benzodioxol-5-ol
CAS No.: 1211539-82-0
Chemical Name: 2,2-Difluoro-1,3-benzodioxol-5-ol
Synonyms: 2,2-Difluorobenzodioxol-5-ol;2,2-Difluoro-1,3-benzodioxol-5-ol;1,3-Benzodioxol-5-ol, 2,2-difluoro-;2,2-difluorobenzo[d][1,3]dioxol-5-ol
CBNumber: CB92724262
Molecular Formula: C7H4F2O3
Formula Weight: 174.1
MOL File: 1211539-82-0.mol

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2,2-Difluoro-1,3-benzodioxol-5-ol Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: solid
color: White to off-white

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Safety

HS Code: 2932990090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D452743
Product name: 2,2-Difluorobenzodioxol-5-ol
Packaging: 100mg
Price: $450
Updated: 2021/12/16

TRC

Product number: D452743
Product name: 2,2-Difluorobenzodioxol-5-ol
Packaging: 250mg
Price: $950
Updated: 2021/12/16

Matrix Scientific

Product number: 187073
Product name: 2,2-Difluorobenzo[d][1,3]dioxol-5-ol
Purity: 95%
Packaging: 2.500g
Price: $1733
Updated: 2021/12/16

AK Scientific

Product number: 4191DT
Product name: 2,2-Difluorobenzo[d][1,3]dioxol-5-ol
Packaging: 10g
Price: $4160
Updated: 2021/12/16

AK Scientific

Product number: 4191DT
Product name: 2,2-Difluorobenzo[d][1,3]dioxol-5-ol
Packaging: 500mg
Price: $835
Updated: 2021/12/16

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2,2-Difluoro-1,3-benzodioxol-5-ol Chemical Properties,Usage,Production

Uses

2,2-Difluorobenzodioxol-5-ol is used in the preparation of isobenzofuro[6,5-f][1,3]benzodioxolones as small molecule inhibitor of insulin-like growth factor-1 receptor.

Synthesis

33070-32-5

1211539-82-0

General procedure for the synthesis of 2,2-difluorobenzo[d][1,3]dioxol-5-ol from 2,2-difluoro-5-bromo-1,3-benzodioxole: Under nitrogen atmosphere, 0.97 g (17.22 mmol) of potassium hydroxide, 0.20 g (0.42 mmol) of di-tert-butyl (2',4',6'-triisopropyl-3,4,5,6-tetra methyl-[1,1'-biphenyl]-2-yl)phosphine and 0.09 g (0.10 mmol) of tris(dibenzylideneacetone)dipalladium(0) were added to 5 ml of 1,4-dioxane and 5 ml of aqueous solution containing 2.04 g (8.61 mmol) of 2,2-difluoro-5-bromobenzodioxolane. The reaction mixture was stirred at 100°C for 17 hours. After completion of the reaction, 22 ml of 1 M hydrochloric acid was added followed by ethyl acetate for extraction. The aqueous layer was extracted three times with ethyl acetate and the combined organic layers were washed with saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate, filtered and the solvent was removed by distillation under reduced pressure. The crude product obtained was purified by silica gel column chromatography (Expanding agent: heptane/ethyl acetate=80/20) to give 1.42 g (Yield: 94.8%) of 2,2-difluoro-5-hydroxybenzodioxolane as a light yellow oil.1H-NMR (300 MHz, CDCl3, δppm): 6.88 (d, 1H, J=8.7Hz), 6.62 (d , 1H, J=2.4Hz), 6.48 (dd, 1H, J=8.7Hz, 2.4Hz).

References

[1] Patent: US2016/192651, 2016, A1. Location in patent: Paragraph 0294
[2] Patent: US2017/15675, 2017, A1. Location in patent: Paragraph 0951
[3] Patent: US2012/225876, 2012, A1. Location in patent: Page/Page column 58
[4] Patent: US2016/222295, 2016, A1. Location in patent: Paragraph 0103; 0104;
[5] Patent: WO2017/193030, 2017, A1. Location in patent: Page/Page column 127; 128

2,2-Difluoro-1,3-benzodioxol-5-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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2,2-Difluoro-1,3-benzodioxol-5-ol Suppliers

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