ChemicalBook > CAS DataBase List > LDN-214117

LDN-214117

Product Name: LDN-214117
CAS No.: 1627503-67-6
Chemical Name: LDN-214117
Synonyms: CS-1539;LDN-214117;LDN-214117 ，S7627;LDN-214117;LDN214117;LDN-214117 USP/EP/BP;LDN-214117, 10 mM in DMSO;1-(4-(6-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl)phenyl)piperazine;1-[4-[6-Methyl-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenyl]piperazine;Piperazine, 1-[4-[6-methyl-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenyl]-;LDN214117,LDN-214117,ALK2,BMP4,BMP2,Transforming growth factor beta receptors,LDN 214117,BMP6,TGF-β Receptor,diffuse intrinsic pontine glioma(DIPG),oral,ALK3,fibrodysplasia ossificans progressiva (FOP),ALK5,type I receptor kinases,ALK1,bone morphogenetic proteins (BMPs)
CBNumber: CB92729368
Molecular Formula: C25H29N3O3
Formula Weight: 419.52
MOL File: 1627503-67-6.mol

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LDN-214117 Property

Boiling point:: 567.9±50.0 °C(Predicted)
Density: 1.134±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMF:30.0(Max Conc. mg/mL);71.51(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.19(Max Conc. mM)
DMSO:42.67(Max Conc. mg/mL);101.7(Max Conc. mM)
Ethanol:54.0(Max Conc. mg/mL);128.72(Max Conc. mM)
pka: 8.86±0.10(Predicted)
form: Powder
color: Light yellow to yellow

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1119
Product name: LDN-214117
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $128.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1119
Product name: LDN-214117
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $611
Updated: 2025/07/31

Cayman Chemical

Product number: 18006
Product name: LDN-214117
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 18006
Product name: LDN-214117
Purity: ≥98%
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 18006
Product name: LDN-214117
Purity: ≥98%
Packaging: 10mg
Price: $184
Updated: 2024/03/01

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LDN-214117 Chemical Properties,Usage,Production

Uses

LDN 214117 is a highly selective ALK2 inhibitor.

Biological Activity

LDN-214117 is a selective inhibitor of the bone morphogenetic protein (BMP) type I receptor kinases with high selectivity for BMP versus TGF-β signaling, and low cytotoxicity. LDN-214117 inhibited ALK2 most, with a biochemical IC50 of 24 nM, followed by TNIK, RIPK2, and ABL1. LDN-214117 has a cell-based IC50 for BMP6 of approximately 100 nM and 164-fold selectivity for BMP6 versus TGF-β1. Fibrodysplasia ossificans progressiva (FOP) is a debilitating and progressive heterotopic ossification disease caused by activating mutations of ACVR1 encoding the BMP type I receptor kinase ALK2. LDN-214117 had nearly identical binding affinity for wild-type ALK2 and each of the FOP-causing mutants tested.

in vivo

LDN-214117 (p.o., 25 mg/kg, daily, for 14 days) has well-tolerated in mice^[3].

Animal Model:	NOD.SCID mice^[3]
Dosage:	25 mg/kg
Administration:	p.o., daily, for 14 days
Result:	Showed good-tolerated in mice.

LDN-214117 Preparation Products And Raw materials

Raw materials

Preparation Products

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LDN-214117 Suppliers

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1627503-67-6, LDN-214117Related Search:

LDN-212320 LDN-193189 HCl LDN-193189 LDN212854

1-[4-[6-Methyl-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenyl]piperazine

LDN-214117;LDN214117

CS-1539

LDN-214117

1-(4-(6-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl)phenyl)piperazine

Piperazine, 1-[4-[6-methyl-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenyl]-

LDN-214117 USP/EP/BP

LDN214117,LDN-214117,ALK2,BMP4,BMP2,Transforming growth factor beta receptors,LDN 214117,BMP6,TGF-β Receptor,diffuse intrinsic pontine glioma(DIPG),oral,ALK3,fibrodysplasia ossificans progressiva (FOP),ALK5,type I receptor kinases,ALK1,bone morphogenetic proteins (BMPs)

LDN-214117, 10 mM in DMSO

LDN-214117 ，S7627

1627503-67-6

Inhibitors