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ReModelin

Product Name
ReModelin
CAS No.
949912-58-7
Chemical Name
ReModelin
Synonyms
CS-2149;ReModelin;Reaxys ID: 18559527;4-[2-(2-Cyclopentylidenehydrazinyl)-4-thiazolyl]benzonitrile;4-(2-(2-Cyclopentylidenehydrazineyl)thiazol-4-yl)benzonitrile;4- (2- (2-cyclopentylidenehydrazine) thiazol-4-yl) benzonitrile;Benzonitrile, 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-;4-[2-(2-Cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile hydrobromide
CBNumber
CB92729373
Molecular Formula
C15H14N4S
Formula Weight
282.36
MOL File
949912-58-7.mol
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ReModelin Property

Boiling point:
498.9±47.0 °C(Predicted)
Density 
1.31±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble20mg/mL, clear
form 
powder
pka
14.40±0.20(Predicted)
color 
white to beige
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1112
Product name
Remodelin hydrobromide
Purity
≥98% (HPLC)
Packaging
5mg
Price
$138
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1112
Product name
Remodelin hydrobromide
Purity
≥98% (HPLC)
Packaging
25mg
Price
$214
Updated
2024/03/01
Sigma-Aldrich
Product number
5.31066
Product name
Remodelin
Packaging
25MG
Price
$260
Updated
2024/03/01
Cayman Chemical
Product number
17346
Product name
Remodelin
Purity
≥95%
Packaging
1mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
17346
Product name
Remodelin
Purity
≥95%
Packaging
5mg
Price
$109
Updated
2024/03/01
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ReModelin Chemical Properties,Usage,Production

Description

Progeria is a genetic disorder that results in the appearance of premature aging. Genetically, progeria is characterized by a mutation in lamin A, which results in misshapen cell nuclei and DNA damage. Remodelin is a 2-thiazolylhydrazone derivative that, at 10 μM, improves nuclear architecture, chromatin organization, and survival of both cells lacking lamin A and cells from patients with progeria. Remodelin is an inhibitor of N-acetyltransferase 10 (NAT10), which acetylates both histones and microtubules. Mutation of NAT10 mimics the effects of remodelin on nuclear morphology, suggesting that these effects of remodelin require NAT10. Remodelin also has cytotoxic effects against some species of the fungus Candida.

Uses

Remodelin improves nuclear architecture, chromatin organization, and fitness of both human lamin A/C-depleted cells and Hutchinson-Gilford progeria syndrome (HGPS)-derived patient cells. N-acetyltransferase 10 (NAT10) inhibitor.

storage

Store at +4°C

References

1) Larrieu?et al.?(2014),?Chemical Inhibition of NAT10 Corrects Defects of Laminopathic Cells; Science,?344?527 2) Larrieu?et al.?(2018),?Inhibition of the Acetyltransferase NAT10 Normalizes Progeric and Aging Cells by Rebalancing the Transportin-1 Nuclear Import Pathway; Sci. Signal.,?11?eaar5401 3) Balmus?et al.?(2018),?Targeting of NAT10 Enhances Healthspan in a Mouse Model of Human Accelerated Aging Syndrome; Nat. Commun., 9?1700 4) Cobb?et al. (2016),?Prelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradient; Aging Cell,?15?1039 5) Ma?et al.?(2016),?Up regulation of NAT10 promotes metastasis of hepatocellular carcinoma cells through epithelial-to-mesenchymal transition; Am. J. Transl. Res.,?8?4215

ReModelin Preparation Products And Raw materials

Raw materials

Preparation Products

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ReModelin Suppliers

Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
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55
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
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4861
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58
D&C Chemicals
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+86-21-58447131
Fax
+86-21-61642470
Email
1724405207@qq.com
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China
ProdList
472
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Pharmacodia (Beijing) Co.,Ltd
Tel
+86-400-851-9921
Fax
+86-10-82826195
Email
sales@pharmacodia.com
Country
China
ProdList
2317
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Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
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58
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
4601
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55
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
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2853530910@QQ.com
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China
ProdList
8011
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Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
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China
ProdList
131957
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58
Medi-tech Bioscientific Co., Ltd.
Tel
0519-83246372 13585352506
Fax
0519-83246372
Country
China
ProdList
1844
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58
Chuzhou KeMail Chemical Technology Co., Ltd
Tel
0550-5196001 15000891977
Fax
0550-5196001
Email
wj520wjxby@126.com
Country
China
ProdList
1847
Advantage
55
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View Lastest Price from ReModelin manufacturers

Career Henan Chemical Co
Product
ReModelin 949912-58-7
Price
US $1.00/KG
Min. Order
1KG
Purity
97%-99.9%
Supply Ability
100kg
Release date
2019-12-26

949912-58-7, ReModelinRelated Search:


  • ReModelin
  • 4-[2-(2-Cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile hydrobromide
  • 4-[2-(2-Cyclopentylidenehydrazinyl)-4-thiazolyl]benzonitrile
  • CS-2149
  • Benzonitrile, 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-
  • Reaxys ID: 18559527
  • 4-(2-(2-Cyclopentylidenehydrazineyl)thiazol-4-yl)benzonitrile
  • 4- (2- (2-cyclopentylidenehydrazine) thiazol-4-yl) benzonitrile
  • 949912-58-7