ReModelin

Product Name: ReModelin
CAS No.: 949912-58-7
Chemical Name: ReModelin
Synonyms: CS-2149;ReModelin;Reaxys ID: 18559527;4-[2-(2-Cyclopentylidenehydrazinyl)-4-thiazolyl]benzonitrile;4-(2-(2-Cyclopentylidenehydrazineyl)thiazol-4-yl)benzonitrile;4- (2- (2-cyclopentylidenehydrazine) thiazol-4-yl) benzonitrile;Benzonitrile, 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-;4-[2-(2-Cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile hydrobromide
CBNumber: CB92729373
Molecular Formula: C15H14N4S
Formula Weight: 282.36
MOL File: 949912-58-7.mol

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ReModelin Property

Boiling point:: 498.9±47.0 °C(Predicted)
Density: 1.31±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble20mg/mL, clear
form: powder
pka: 14.40±0.20(Predicted)
color: white to beige
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1112
Product name: Remodelin hydrobromide
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $138
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1112
Product name: Remodelin hydrobromide
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $214
Updated: 2024/03/01

Sigma-Aldrich

Product number: 5.31066
Product name: Remodelin
Packaging: 25MG
Price: $260
Updated: 2024/03/01

Cayman Chemical

Product number: 17346
Product name: Remodelin
Purity: ≥95%
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 17346
Product name: Remodelin
Purity: ≥95%
Packaging: 5mg
Price: $109
Updated: 2024/03/01

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ReModelin Chemical Properties,Usage,Production

Description

Progeria is a genetic disorder that results in the appearance of premature aging. Genetically, progeria is characterized by a mutation in lamin A, which results in misshapen cell nuclei and DNA damage. Remodelin is a 2-thiazolylhydrazone derivative that, at 10 μM, improves nuclear architecture, chromatin organization, and survival of both cells lacking lamin A and cells from patients with progeria. Remodelin is an inhibitor of N-acetyltransferase 10 (NAT10), which acetylates both histones and microtubules. Mutation of NAT10 mimics the effects of remodelin on nuclear morphology, suggesting that these effects of remodelin require NAT10. Remodelin also has cytotoxic effects against some species of the fungus Candida.

Uses

Remodelin improves nuclear architecture, chromatin organization, and fitness of both human lamin A/C-depleted cells and Hutchinson-Gilford progeria syndrome (HGPS)-derived patient cells. N-acetyltransferase 10 (NAT10) inhibitor.

storage

Store at +4°C

References

1) Larrieu?et al.?(2014),?Chemical Inhibition of NAT10 Corrects Defects of Laminopathic Cells; Science,?344?527 2) Larrieu?et al.?(2018),?Inhibition of the Acetyltransferase NAT10 Normalizes Progeric and Aging Cells by Rebalancing the Transportin-1 Nuclear Import Pathway; Sci. Signal.,?11?eaar5401 3) Balmus?et al.?(2018),?Targeting of NAT10 Enhances Healthspan in a Mouse Model of Human Accelerated Aging Syndrome; Nat. Commun., 9?1700 4) Cobb?et al. (2016),?Prelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradient; Aging Cell,?15?1039 5) Ma?et al.?(2016),?Up regulation of NAT10 promotes metastasis of hepatocellular carcinoma cells through epithelial-to-mesenchymal transition; Am. J. Transl. Res.,?8?4215

ReModelin Preparation Products And Raw materials

Raw materials

Preparation Products

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ReModelin Suppliers

China 82 The Netherlands 1 United Kingdom 2 United States 11 Global 96

Shanghai Boyle Chemical Co., Ltd.

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MedChemexpress LLC

Tel: 021-58955995
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Email: sales@medchemexpress.cn
Country: United States
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TargetMol Chemicals Inc.

Tel: 021-33632979 15002134094
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Email: marketing@targetmol.com
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D&C Chemicals

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Pharmacodia (Beijing) Co.,Ltd

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Shanghai EFE Biological Technology Co., Ltd.

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Tianjin Kailiqi Biotechnology Co., Ltd.

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ShangHai Biochempartner Co.,Ltd

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Amadis Chemical Company Limited

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Medi-tech Bioscientific Co., Ltd.

Tel: 0519-83246372 13585352506
Fax: 0519-83246372
Country: China
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View Lastest Price from ReModelin manufacturers

Career Henan Chemical Co

Product: ReModelin 949912-58-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 100kg
Release date: 2019-12-26

949912-58-7, ReModelinRelated Search:

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ReModelin

4-[2-(2-Cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile hydrobromide

4-[2-(2-Cyclopentylidenehydrazinyl)-4-thiazolyl]benzonitrile

CS-2149

Benzonitrile, 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-

Reaxys ID: 18559527

4-(2-(2-Cyclopentylidenehydrazineyl)thiazol-4-yl)benzonitrile

4- (2- (2-cyclopentylidenehydrazine) thiazol-4-yl) benzonitrile

949912-58-7