ReModelin

Product Name: ReModelin
CAS No.: 949912-58-7
Chemical Name: ReModelin
Synonyms: CS-2149;ReModelin;Reaxys ID: 18559527;4-[2-(2-Cyclopentylidenehydrazinyl)-4-thiazolyl]benzonitrile;4-(2-(2-Cyclopentylidenehydrazineyl)thiazol-4-yl)benzonitrile;4- (2- (2-cyclopentylidenehydrazine) thiazol-4-yl) benzonitrile;Benzonitrile, 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-;4-[2-(2-Cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile hydrobromide
CBNumber: CB92729373
Molecular Formula: C15H14N4S
Formula Weight: 282.36
MOL File: 949912-58-7.mol

More

Less

ReModelin Property

Boiling point:: 498.9±47.0 °C(Predicted)
Density: 1.31±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble20mg/mL, clear
form: powder
pka: 14.40±0.20(Predicted)
color: white to beige
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1112
Product name: Remodelin hydrobromide
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $138
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1112
Product name: Remodelin hydrobromide
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $214
Updated: 2024/03/01

Sigma-Aldrich

Product number: 5.31066
Product name: Remodelin
Packaging: 25MG
Price: $260
Updated: 2024/03/01

Cayman Chemical

Product number: 17346
Product name: Remodelin
Purity: ≥95%
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 17346
Product name: Remodelin
Purity: ≥95%
Packaging: 5mg
Price: $109
Updated: 2024/03/01

More

Less

ReModelin Chemical Properties,Usage,Production

Description

Progeria is a genetic disorder that results in the appearance of premature aging. Genetically, progeria is characterized by a mutation in lamin A, which results in misshapen cell nuclei and DNA damage. Remodelin is a 2-thiazolylhydrazone derivative that, at 10 μM, improves nuclear architecture, chromatin organization, and survival of both cells lacking lamin A and cells from patients with progeria. Remodelin is an inhibitor of N-acetyltransferase 10 (NAT10), which acetylates both histones and microtubules. Mutation of NAT10 mimics the effects of remodelin on nuclear morphology, suggesting that these effects of remodelin require NAT10. Remodelin also has cytotoxic effects against some species of the fungus Candida.

Uses

Remodelin improves nuclear architecture, chromatin organization, and fitness of both human lamin A/C-depleted cells and Hutchinson-Gilford progeria syndrome (HGPS)-derived patient cells. N-acetyltransferase 10 (NAT10) inhibitor.

storage

Store at +4°C

References

1) Larrieu?et al.?(2014),?Chemical Inhibition of NAT10 Corrects Defects of Laminopathic Cells; Science,?344?527 2) Larrieu?et al.?(2018),?Inhibition of the Acetyltransferase NAT10 Normalizes Progeric and Aging Cells by Rebalancing the Transportin-1 Nuclear Import Pathway; Sci. Signal.,?11?eaar5401 3) Balmus?et al.?(2018),?Targeting of NAT10 Enhances Healthspan in a Mouse Model of Human Accelerated Aging Syndrome; Nat. Commun., 9?1700 4) Cobb?et al. (2016),?Prelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradient; Aging Cell,?15?1039 5) Ma?et al.?(2016),?Up regulation of NAT10 promotes metastasis of hepatocellular carcinoma cells through epithelial-to-mesenchymal transition; Am. J. Transl. Res.,?8?4215

ReModelin Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

ReModelin Suppliers

China 86 The Netherlands 1 United Kingdom 2 United States 12 Global 101

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38632
Advantage: 58

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

Focus Biomolecules

Tel: --
Fax: --
Email: sales@focusbiomolecules.com
Country: United States
ProdList: 1284
Advantage: 58

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

United States Biological

Tel: --
Fax: --
Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

Axon Medchem LLC

Tel: --
Fax: --
Email: info@axonmedchem.com
Country: United States
ProdList: 763
Advantage: 58

More

Less

View Lastest Price from ReModelin manufacturers

Career Henan Chemical Co

Product: ReModelin 949912-58-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 100kg
Release date: 2019-12-26

949912-58-7, ReModelinRelated Search:

KU57788(NU7441) N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate (1:1) Fruquintinib|HMPL-013 Acalabrutinib ReModelin hydrobroMide

ReModelin

4-[2-(2-Cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile hydrobromide

4-[2-(2-Cyclopentylidenehydrazinyl)-4-thiazolyl]benzonitrile

CS-2149

Benzonitrile, 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-

Reaxys ID: 18559527

4-(2-(2-Cyclopentylidenehydrazineyl)thiazol-4-yl)benzonitrile

4- (2- (2-cyclopentylidenehydrazine) thiazol-4-yl) benzonitrile

949912-58-7