4-Chloro-6-Methyl-2-(Methylthio)pyriMidine-5-carbonitrile

Product Name: 4-Chloro-6-Methyl-2-(Methylthio)pyriMidine-5-carbonitrile
CAS No.: 1208170-17-5
Chemical Name: 4-Chloro-6-Methyl-2-(Methylthio)pyriMidine-5-carbonitrile
Synonyms: 4-Chloro-6-methyl-2-(methylthio)pyrimidine-5-;4-Chloro-6-Methyl-2-(Methylthio)pyriMidine-5-carbonitrile;4-Chloro-6-methyl-2-(methylthio)-5-pyrimidinecarbonitrile;5-Pyrimidinecarbonitrile, 4-chloro-6-methyl-2-(methylthio)-
CBNumber: CB92729434
Molecular Formula: C7H6ClN3S
Formula Weight: 199.66
MOL File: 1208170-17-5.mol

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4-Chloro-6-Methyl-2-(Methylthio)pyriMidine-5-carbonitrile Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: White to off-white Solid

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 125520
Product name: 4-Chloro-6-methyl-2-(methylthio)-pyrimidine-5-carbonitrile
Purity: 97%
Packaging: 500mg
Price: $155
Updated: 2021/12/16

Matrix Scientific

Product number: 125520
Product name: 4-Chloro-6-methyl-2-(methylthio)-pyrimidine-5-carbonitrile
Purity: 97%
Packaging: 1g
Price: $239
Updated: 2021/12/16

Apolloscientific

Product number: OR345713
Product name: 4-Chloro-6-methyl-2-(methylthio)pyrimidine-5-carbonitrile
Packaging: 1g
Price: $361
Updated: 2021/12/16

SynQuest Laboratories

Product number: 7H66-5-0D
Product name: 4-Chloro-6-methyl-2-(methylthio)pyrimidine-5-carbonitrile
Packaging: 1g
Price: $428
Updated: 2021/12/16

Matrix Scientific

Product number: 125520
Product name: 4-Chloro-6-methyl-2-(methylthio)-pyrimidine-5-carbonitrile
Purity: 97%
Packaging: 5g
Price: $837
Updated: 2021/12/16

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4-Chloro-6-Methyl-2-(Methylthio)pyriMidine-5-carbonitrile Chemical Properties,Usage,Production

Synthesis

89853-27-0

1208170-17-5

General procedure for the synthesis of 4-chloro-6-methyl-2-methylthio-5-cyanopyrimidine from 4-amino-6-methyl-2-methylthio-5-cyanopyrimidine: 4-amino-6-methyl-2-(methylthio)pyrimidine-5-carbonitrile (50 g, 0.278 mol) was added to a solution of acetonitrile (800 mL) containing anhydrous copper(II) chloride (44.7 g, 0.334 mol), tert-butyl nitrite (51.6 mL, 0.500 mol) and MgSO4 (10 mg) in a solution of acetonitrile (800 mL) and the reaction was stirred at 80 °C. After 3 hours of reaction, the mixture was cooled to room temperature and filtered. The filtrate was concentrated and the residue was dissolved in ethyl acetate, washed sequentially with water and brine, dried over MgSO4 and concentrated. The crude product was purified by column chromatography (eluent: petroleum ether/ethyl acetate = 3:1, subsequently adjusted to 3:2) to afford the target product 4-chloro-6-methyl-2-methylthio-5-cyanopyrimidine as a white solid (33 g, 59% yield). Mass spectrum (MS): m/z=200.11 ([M+1]+). 1H NMR (300 MHz, DMSO) δ 2.69 (3H, s, CH3), 2.61 (3H, s, SCH3).

References

[1] Patent: WO2010/19637, 2010, A1. Location in patent: Page/Page column 55
[2] Patent: WO2012/97683, 2012, A1. Location in patent: Page/Page column 83
[3] Patent: US2014/171429, 2014, A1. Location in patent: Paragraph 0349

4-Chloro-6-Methyl-2-(Methylthio)pyriMidine-5-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Chloro-6-Methyl-2-(Methylthio)pyriMidine-5-carbonitrile Suppliers

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